A5052616041- Gut microbiota and health
- Diet and metabolism studies
- RNA Research and Splicing
- Clostridium difficile and Clostridium perfringens research
- RNA and protein synthesis mechanisms
- Gastrointestinal motility and disorders
- RNA modifications and cancer
- Probiotics and Fermented Foods
- Dietary Effects on Health
Czech Academy of Sciences, Institute of Microbiology
2022-2023
ETH Zurich
2020-2023
Abstract The Integrator complex processes 3′-ends of spliceosomal small nuclear RNAs (snRNAs). Furthermore, it regulates transcription protein coding genes by terminating after unstable pausing. molecular basis for Integrator’s functions remains obscure. Here, we show that INTS10, Asunder/INTS13 and INTS14 form a separable, functional module. structure INTS13-INTS14 reveals strongly entwined with unique chain interlink. Unexpected structural homology to the Ku70-Ku80 DNA repair suggests...
The capacity of the intestinal microbiota to degrade otherwise indigestible diet components is known greatly improve recovery energy from food. This has led hypothesis that increased digestive efficiency may underlie contribution obesity. OligoMM12-colonized gnotobiotic mice have a consistently higher fat mass than germ-free (GF) or fully colonized counterparts. We therefore investigated their food intake, digestion efficiency, expenditure, and respiratory quotient using novel...
Many microbiota-based therapeutics rely on our ability to introduce a microbe of choice into an already-colonized intestine. In this study, we used genetically barcoded Bacteroides thetaiotaomicron ( B. theta ) strains quantify population bottlenecks experienced by during colonization the mouse gut. As expected, reveals inverse relationship between microbiota complexity and probability that individual wildtype clone will colonize The polysaccharide capsule is important for resistance against...