To construct an immune-related gene prognostic index (IRGPI) for breast cancer (BC) and investigate its specificity the molecular immune characteristics. BC hub genes were identified from The Cancer Genome Atlas databases using weighted co-expression network analysis (WGCNA). IRGPI was constructed univariate, LASSO, multivariate regression analyses, validated with GSE58812 GSE97342 in Gene Expression Omnibus database (GEO). At same time, we evaluated predictive ability of different subtypes....

In this paper, a new model identification method is developed for class of delay fractional-order system based on the process step response. Four characteristic functions are defined to characterize features normalized model. Based time scaling technology, two schemes proposed parameters U+02BC estimation. The scheme one utilizes three exact points response calculate directly. other employs optimal searching adjust fractional order best identification. both applicable any stable complex...

This study aimed to investigate the beneficial effects of ε-Viniferin on hyperglycemia and hyperlipidemia, reveal underlying mechanism.

Spectral clustering algorithm has proved be more effective than most traditional algorithms in finding clusters. However, its high computational complexity limits effect actual application. This paper combines the spectral with MapReduce, through evaluation of sparse matrix eigenvalue and computation distributed cluster, puts forward improvement ideas concrete realization, thus improves speed distinctive algorithm. According to experiment, processing data scale being enlarged, rate is nearly...

Lung cancer is the leading cause of cancer‐related mortality in men and women globally. Non‐small cell lung (NSCLC) most prevalent subtype, accounting for 85–90% all cancers. Although there have been dramatic advances therapeutic approaches recent decades, recurrence metastasis rates NSCLC are as high 30–40% with 5‐year overall survival rate being less than 15%. Therefore, it necessary to explore pathogenesis at genetic level identify prognostic biomarkers novel targets. Here, we aimed...

To investigate the effects of multiple doses baicalin (BG) on pharmacokinetics ciclosporin (CsA) in rats and potential mechanisms.Pharmacokinetic parameters CsA were determined male after administration (3 mg/kg, i.g. or i.v.) to presence absence BG (80 for 7 days. The livers intestines isolated CYP3A p-glycoprotein (P-gp) expression analysed. effect intestinal absorptive behaviour was also investigated using in-vitro everted rat gut sac model.Baicalin i.v., days) had no intravenously...

Objective . To investigate the clinicopathological characteristics and risk factors in patients with lung cancer COPD. Materials Methods We retrospectively reviewed clinical data of 282 cancer, including 174 108 without COPD, respectively. Information on age, sex, smoking status, histologic type was obtained from medical records. Results Lung COPD those chronic bronchitis (CB) phenotype had higher indices compared to (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mn...

An improved disturbance rejection control based on the combination of an extended‐state observer (ESO) and Q ‐filter is presented for piezoelectric actuators. Analysis using standard framework performed to verify that new method can improve accuracy estimation even under measurement noise. advantage proposed bandwidth ESO be reduced without degradation performance. experiment validate effectiveness method.

Introduction: This study aimed to explore the associations between constitutions of traditional Chinese medicine (TCM) and coronary artery disease (CAD). Methods: A large-scale, community-based, cross-sectional was performed investigate associations. total 3,748 participants were available for analysis in this study. The assessment constitution TCM based on recommendations by Association Medicine China. In study, a diagnosis CAD self-reported medical history. analyzed using univariate...

Control of fractional-order systems has attracted more and attention in many fields. Time delay is an inherent phenomenon the real process, but control techniques available for system with time cannot guarantee robustness performance. In this paper, stabilizing optimal PID controller tuning methods are proposed systems. The requirements on both robust stability frequency domain transient performance met. Comparisons made among four controllers to reveal relationship between parameters via...

An asymmetric Prandtl–Ishlinskii (API) hysteresis model for a giant magnetostrictive actuator (GMA) is proposed in this paper. The classical (PI) analyzed and divided into two parts: linear function operator summation. To enhance asymmetry, polynomial used the API as center curve of instead function. remaining modeled by new that provides some basic hysteresis. In manner, requires relatively less operators fewer parameters to describe behavior GMA. All are identified standard least square...

The exists of hysteresis nonlinearities in some physical system such as piezoelectric actuators can cause reduction control accuracy and even instability system. In this paper, a strategy based on Extended State Observer (ESO) is proposed for systems with characteristics to achieve accurate output tracking the reference model which provides desired performance. Firstly, nonlinear was transformed into linear preceded by disturbance input. Secondly, controlled object Equivalent Feedback Model...

Background:Epidemiological studies have confirmed the potential role of estrogen effects in influencing development and outcome leukemia.Estrogen are increasingly attracting research interest for their antitumor beyond gynecological tumors.However, causal relationship remains unclear.Methods: In a novel approach, this study integrates single-cell RNA sequencing (scRNA-seq) with Mendelian randomization (MR) to explore between (and its receptor) leukemia related proteins).This integration...

Abstract MA algorithms have received extensive attention from scholars soon after they were proposed, and are rapidly developing in various fields such as the problem of project schedule optimal allocation cloud resources. In this paper, firstly, to address lack performance ordinary algorithm, Kent chaotic mapping is used initialization position improve initial traversal ability, Sigmoid function introduced optimize step-size settings different stages crawling process. Different test...