A5085240510- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Immune cells in cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer Treatment and Pharmacology
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- Bioinformatics and Genomic Networks
- Advanced Breast Cancer Therapies
- Natural product bioactivities and synthesis
- Cancer Cells and Metastasis
- Histone Deacetylase Inhibitors Research
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- HER2/EGFR in Cancer Research
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
- Breast Cancer Treatment Studies
- Inflammasome and immune disorders
Weifang Chinese Medicine Hospital
2016-2025
Shandong University of Traditional Chinese Medicine
2018-2025
Weifang Medical University
2018-2025
Macau University of Science and Technology
2023-2025
Shandong Academy of Chinese Medicine
2021-2022
Uppsala University
2021-2022
First Hospital of Jilin University
2021
Jilin University
2021
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2019
Qingdao University
2019
Growing evidence has shown that a large number of miRNAs are abnormally expressed in cervical cancer (CC) tissues and play irreplaceable roles tumorigenesis, progression, metastasis. This study aimed to identify new biomarkers pivotal genes associated with CC prognosis through comprehensive bioinformatics analysis. At first, the data gene expression microarray (GSE30656) was downloaded from GEO database differential were obtained. Additionally, 4 survival time patients screened TCGA...
Based on the tumor hypoxic microenvironment and new programmed cell death mode of combined ferroptosis, an angelica polysaccharide-based nanocarrier material was synthesized. The polymer contains hydrophilic polysaccharide (ASP) that is linked by azobenzene (AZO) linker with ferrocene (Fc), then side chain covalently modified arachidonic acid (AA). It postulated micelles could work as instinctive liver targeting drug delivery carrier, owing to existence ASP targeting. Moreover, aim engineer...
T cell senescence is an indication of dysfunction. The ability senescent cells to respond cognate antigens reduced and they are in the late stage differentiation proliferation; therefore, cannot recognize eliminate tumor a timely effective manner, leading formation suppressive microenvironment. Establishing methods reverse particularly important for immunotherapy. Aging exacerbates profound changes immune system, increased susceptibility chronic, infectious, autoimmune diseases. Patients...
During tumor development, the itself must continuously generate new blood vessels to meet their growth needs while also allowing for invasion and metastasis. One of most common features tumors is hypoxia, which drives process angiogenesis by regulating microenvironment, thus adversely affecting prognosis patients. In addition, overcome unsuitable environments growth, such as nutrient deficiency, hyperacidity, immunosuppression, microenvironment (TME) coordinates in several ways restore...
Due to the unique characteristics of breast cancer initiation sites and significant alterations in tumor metabolism, cells rely on lipid metabolic reprogramming effectively regulate programs during disease progression cascade.This adaptation enables them meet energy demands required for proliferation, invasion, metastasis, responses signaling molecules microenvironment.In this review, we comprehensively examined distinctive features elucidated underlying mechanisms driving aberrant behavior...
There has been increasing attention on immune-oncology for its impressive clinical benefits in many different malignancies. However, due to molecular and genetic heterogeneity of tumors, the activities traditional pathological criteria are far from satisfactory. Immune-based strategies have re-ignited hopes treatment prevention breast cancer. Prognostic or predictive biomarkers, associated with tumor immune microenvironment, may great prospects guiding patient management, identifying new...