A5024597866- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Cannabis and Cannabinoid Research
- Nuclear Receptors and Signaling
- Stress Responses and Cortisol
- Pain Mechanisms and Treatments
- Diabetes Management and Research
- Neuroendocrine regulation and behavior
- Neural and Behavioral Psychology Studies
- RNA regulation and disease
- Diabetes Treatment and Management
- Neural dynamics and brain function
- Parkinson's Disease Mechanisms and Treatments
- Hormonal Regulation and Hypertension
- Adipose Tissue and Metabolism
- Youth, Drugs, and Violence
- Pharmacological Effects and Assays
- Chronic Kidney Disease and Diabetes
- Attention Deficit Hyperactivity Disorder
- Memory and Neural Mechanisms
- Regulation of Appetite and Obesity
- RNA Interference and Gene Delivery
- Nerve injury and regeneration
Pontificia Universidad Católica de Chile
2015-2024
Drexel University
2017
Millennium Science Initiative
2015
University of Chile
2006
Extracellular levels of norepinephrine (NE) and glutamate (Glu) in the ventral bed nucleus stria terminalis (vBNST) saline- chronic morphine-treated rats, with or without withdrawal, were studied by means vivo microdialysis technique anesthetized rats. In addition, tissue concentration NE was at different rostrocaudal vBNST. Chronic morphine treatment significantly increased extracellular NE, but not Glu, At 48 h after naloxone-induced withdrawal there a further significant increase The...
Nurr1 is a transcription factor essential for the development of ventral dopaminergic neurons. In search regulatory mechanisms function, we identified SUMO (small ubiquitin-like modifier)-E3 ubiquitin-protein isopeptide ligase, PIASγ, as an interaction partner Nurr1. Overexpressed PIASγ and co-localize in nuclei transfected cells, their demonstrated through co-immunoprecipitation glutathione S-transferase pulldown assays. Co-expression with results potent repression Nurr1-dependent...
J. Neurochem. (2010) 114 , 1158–1167. Abstract Genesis of midbrain dopamine (DA) neurons depends on Nurr1, a nuclear receptor expressed during development and adulthood in these neurons. Nurr1 is required for the expression genes dopaminergic phenotype such as tyrosine hydroxylase DA transporter. The kinase RET also development. However, it unknown whether regulated by adulthood, mechanism which regulates expression. Using an adeno‐associated vector‐delivered anti‐Nurr1 ribozyme, we...
Reinforcing properties of drugs abuse are reduced by the coadministration kappa opioid receptor (KOR) agonists. This effect is related to inhibition dopamine (DA) release in nucleus accumbens (NAc) produced acute administration KOR The present study was undertaken investigate vivo repeated agonist on extracellular DA levels NAc. Rats were injected once daily with selective U-69593 (0.16–0.32 mg/kg) or vehicle for 4 days. Microdialysis studies assessing concentration NAc under basal and...
Dopamine from the ventral tegmental area and glutamate several brain nuclei converge in nucleus accumbens (NAc) to drive motivated behaviors. Repeated activation of D2 receptors with quinpirole (QNP) induces locomotor sensitization compulsive behaviors, but mechanisms are unknown. In this study, vivo microdialysis fast scan cyclic voltammetry adult anesthetized rats were used investigate effect repeated QNP on dopamine neurotransmission within NAc. Following eight injections QNP, a...
Increased locomotor activity in response to the same stimulus is an index of behavioral sensitization observed preclinical models drug addiction and compulsive behaviors. Repeated administration quinpirole, a D2/D3 dopamine agonist, induces sensitization. This effect potentiated accelerated by co-administration U69593, kappa opioid receptor agonist. The mechanism underlying potentiation quinpirole-induced remains be elucidated.
Nurr1 is a transcription factor essential for the genesis of ventral dopaminergic neurons. In this study, we investigated expression protein and mRNA in adult rat brain by using immunohistochemistry situ hybridization, respectively. Another aim our study was to investigate substantia nigra after dopamine depletion induced injection 6-hydroxydopamine striatum. We observed that are expressed several regions, including cortex, hippocampus, nigra, tegmental area, agreement with previous reports...
Abstract Kappa‐opioid receptors ( KOR ) control dopamine DA levels in the striatum and contribute significantly to progression of drug addiction. Repeated exposure psychostimulants has been associated with up‐regulated activity increased dorsal striatum. However, it not tested if both processes are linked. In this work, we studied a mechanism mediated by is contributing increase dorsolateral DLS after amphetamine AMPH sensitization. The sensitization was assessed single or repeated...
Abstract Acute administration of kappa opioid receptor (KOR) agonists decreases both dopamine (DA) extracellular levels in the nucleus accumbens (NAc) and locomotor activity. Opposing to its acute effects, recent studies show that chronic KOR potentiates stimulated DA release induced Since have been considered as potential treatment for stimulant dependence, effects their repeated on psychostimulant actions are major concern. The present study was undertaken investigate vivo effect agonist...
Acute activation of κ-opioid receptors (KOR) decreases dopamine (DA) extracellular levels in both the medial prefrontal cortex (mPFC) and nucleus accumbens (NAc). Also, acute KOR prevents alterations behavior neurochemistry occurring after repeated use psychostimulants. Opposing to effects, administration agonist, U-6593, potentiates high-potassium amphetamine induced DA release NAc, suggesting that sensitizes mesolimbic dopaminergic neurotransmission. This study investigated effect...
During adolescence, neuronal circuits exhibit plasticity in response to physiological changes and adapt environmental events. Nigrostriatal dopaminergic pathways are constant flux during development. Evidence suggests a relationship between early use of cannabinoids psychiatric disorders characterized by altered systems, such as schizophrenia addiction. However, the impact adolescent exposure on nigrostriatal adulthood remains unclear. The aim this research was determine effects repeated...