A5047116903- Neurotransmitter Receptor Influence on Behavior
- Substance Abuse Treatment and Outcomes
- Neuroscience and Neuropharmacology Research
- Alcohol Consumption and Health Effects
- Neural and Behavioral Psychology Studies
- Schizophrenia research and treatment
- Cannabis and Cannabinoid Research
- Mental Health Research Topics
- Functional Brain Connectivity Studies
- Alcoholism and Thiamine Deficiency
- Behavioral Health and Interventions
- Stress Responses and Cortisol
- Opioid Use Disorder Treatment
- Alzheimer's disease research and treatments
- Genetic Mapping and Diversity in Plants and Animals
- Coffee research and impacts
- Cognitive Functions and Memory
- Receptor Mechanisms and Signaling
- Tryptophan and brain disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Bipolar Disorder and Treatment
- Prenatal Substance Exposure Effects
- Cholesterol and Lipid Metabolism
- Advanced MRI Techniques and Applications
- Heart Rate Variability and Autonomic Control
The University of Sydney
2010-2025
Sydney Local Health District
2021-2025
Royal Prince Alfred Hospital
2020-2025
King George V Memorial Hospital
2025
Macquarie University
2016-2023
American Society of Addiction Medicine
2022
La Trobe University
2021
National Health and Medical Research Council
2016-2019
Neuroscience Research Australia
2011-2014
Schizophrenia Research Institute
2011-2014
Chapter 2: Screening and assessment for unhealthy alcohol use appropriate interventions should be implemented in general practice (Level A), hospitals B), emergency departments community health welfare settings C). Quantity-frequency measures can detect consumption that exceeds levels the current Australian guidelines B). The Alcohol Use Disorders Identification Test (AUDIT) is most effective screening tool recommended primary care hospital settings. For community, AUDIT-C a suitable...
Objective: There have been no well-controlled and well-powered comparative trials of topiramate with other pharmacotherapies for alcohol use disorder (AUD), such as naltrexone. Moreover, the literature is mixed on effects two polymorphisms—rs2832407 (in GRIK1) rs1799971 OPRM1)—on response to naltrexone, respectively. The authors sought examine effectiveness naltrexone in improving outcomes AUD role rs2832407 polymorphisms, respectively, these medications. Methods: In a 12-week, double-blind,...
Current treatments for alcohol use disorders (AUD) have limited efficacy. Recently, Cannabidiol (CBD) has been examined in a multitude of clinical settings. Preclinical and results suggest that CBD might be particularly well suited the treatment AUD may reduce cue stress-induced craving seeking. This study aims to investigate this new pharmacotherapy with particular focus on neurobiological physiological indicators craving.
Preclinical studies have demonstrated that cannabidiol (CBD) reduces alcohol-seeking behaviors and may potential for managing alcohol use disorder (AUD). In this study, we examined the effects of CBD versus placebo on (i) psychophysiological, craving anxiety responses to appetitive cues; (ii) tolerability measures including cognitive functioning. Twenty-two non-treatment-seeking individuals with AUD (DSM-5) participated in a cross-over, double-blind, randomized trial, receiving either 800 mg...
Abstract Alcohol use disorder (AUD) is a prevalent psychiatric condition characterised by problematic alcohol consumption and craving, necessitating the exploration of novel therapeutic interventions. Cannabidiol (CBD), non-psychoactive component cannabis, has shown potential in modulating neural processes associated with substance disorders including AUD. This study aimed to investigate effect CBD on cue-induced activation neurocircuitry impact mood, cognitive functioning individuals In...
ATP-binding cassette transporters of the subfamily A (ABCA) are responsible for translocation lipids including cholesterol, which is crucial neurological function. Recent studies suggest that ABC transporter ABCA7 may play a role in development brain disorders such as schizophrenia and Alzheimer's disease. However, Abca7's cognition other behaviours has not been investigated. Therefore, we characterised homozygous Abca7 knockout mice battery tests baseline (i.e. physical exam, locomotion...
Abstract Rationale Both topiramate and naltrexone have been shown to affect neural alcohol cue reactivity in use disorder (AUD). However, their comparative effects on are unknown. Moreover, while has found normalize hyperactive localized network connectivity implicated AUD, no studies examined the effect of intrinsic functional or compared between these two widely used medications. Objective This study versus cue-elicited brain activation patients with disorder. Methods Forty-seven...
Technological developments over recent decades have produced a novel housing system for laboratory mice, so-called 'individually ventilated cage' (IVC) systems. IVCs present cage environment which is different to conventional filter-top cages (FILTER). Nothing known about the consequences of IVC on genetic mouse models, despite studies reporting IVC-mediated changes phenotypes inbred strains. Thus, in this study, we systematically compared established behavioural phenotype validated model...
Introduction: Individuals with alcohol use disorder (AUD) have difficulties regulating consumption, despite adverse drinking-related consequences. This may be due to incapacity incorporating previous negative feedback from drinking, resulting in impaired decision-making. Methods: We assessed whether decision-making is participants AUD related severity of AUD, indexed by severe drinking consequences using the Drinkers Inventory Consequences (DrInC) and reward punishment sensitivity...
To examine subjective and psychophysiological responses to appetitive cues during an alcohol cue reactivity task, its relation alcoholic liver disease assess whether executive functioning is associated with appropriate regulation of cue-elicited in individuals severe use disorder (AUD).Seventeen treatment-seeking patients a control group AUD participants completed neuropsychological measures (Stroop task; Trail-making test) the whereby (water) beverage were presented, followed by respective...
Baclofen, a selective γ-aminobutyric acid (GABA)B receptor agonist, has emerged as potential treatment for alcohol use disorder with much unexplained variation in response to efficacy and dose regimen. Several positive studies include patients alcoholic liver disease (ALD) and/or history of heavy drinking. The aim this paper was examine the association cortical GABA+ concentration severity (including markers injury) other clinical characteristics patients.Proton magnetic resonance...
Abstract N-acetyl cysteine (NAC) is a potential pharmacotherapy for alcohol use disorder (AUD), but it not known whether modulates neural activation to cues or intrinsic functional connectivity. We investigated NAC attenuates (i) cue-elicited activation, and (ii) connectivity compared placebo in patients with AUD. In this preliminary study, twenty-three individuals (7 females) moderate-severe AUD received daily (2400 mg/day, n = 9), ( 14) at least 2 weeks. Participants completed...
Background and Aims: Baclofen, a GABAB agonist, is used as treatment for alcohol dependence. We aimed to examine brain metabolites following administration of baclofen or placebo in dependent individuals enrolled randomized placebo-controlled trial. Methods: Participants included 31 (recent drinking: N = 16; abstinent: 15) who had received daily (BAC 30-75 mg 20) (PL 11) at least 2 weeks (average 17 days). Using vivo proton magnetic resonance spectroscopy (1H-MRS), spectra from the right...
Abstract Objective To assess whether baclofen‐treated alcohol dependent participants show different subjective and psychophysiological responses to appetitive cues during an cue reactivity task compared placebo, these are associated with prospective drinking outcomes. Methods Forty‐two (placebo: n = 12, low‐dose baclofen [30 mg/day] 18, high‐dose [75 mg/day]: 12) completed task, whereby water beverage were presented, subsequent recovery periods, craving indices (skin conductance;...