A5053065965- Organometallic Complex Synthesis and Catalysis
- Crystallization and Solubility Studies
- Synthetic Organic Chemistry Methods
- Dendrimers and Hyperbranched Polymers
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Catalytic Cross-Coupling Reactions
- Carbohydrate Chemistry and Synthesis
- X-ray Diffraction in Crystallography
- Advanced Proteomics Techniques and Applications
- Fluorine in Organic Chemistry
- Crystallography and molecular interactions
- Nanopore and Nanochannel Transport Studies
- Chemical Synthesis and Analysis
- Molecular spectroscopy and chirality
- Microbial Natural Products and Biosynthesis
- Enzyme Catalysis and Immobilization
- Protein Structure and Dynamics
- Organoboron and organosilicon chemistry
- Microbial Metabolic Engineering and Bioproduction
- Asymmetric Synthesis and Catalysis
- Metal complexes synthesis and properties
Eli Lilly (Spain)
2017-2022
Eli Lilly (United States)
2020
Lilly (China)
2020
GEICAM – Spanish Breast Cancer Group
2020
Universidad de Alcalá
2009-2016
The human insulin receptor signalling system plays a critical role in glucose homeostasis. Insulin binding brings about extensive conformational change the extracellular region that turn effects trans-activation of intracellular tyrosine kinase domains and downstream signalling. Of particular therapeutic interest is whether can be replicated by molecules other than insulin. Here, we present single-particle cryoEM structures show how 33-mer polypeptide unrelated to cross-link two sites on...
Abstract A series of mono‐ and dendritic trimetallic PEPPSI‐type (pyridine‐enhanced precatalyst preparation stabilization initiation) complexes bearing N‐heterocyclic carbene (NHC) ligands containing a protected amine in the form an ethylphthalimido group have been synthesized. These discrete prototypes covalently bound to suitable supports studied Mizoroki–Heck coupling aryl iodides under mild conditions, including sets experiments assess lifetime active species. The palladated dendrons are...
Mono- and bis(NHC) Pd complexes grafted onto magnetic particles are compared as catalysts in the Suzuki–Miyaura reaction aqueous media. The latter is found to be an outstanding recyclable catalyst.
Abstract This overview covers the most relevant results obtained by our group in last few years concerning synthesis and catalytic applications of metal complexes anchored to surface carbosilane dendrimers functionalized with iminopyridine ligands. Nickel dibromide activated methylaluminoxane (MAO) have been studied for polymerization ethylene, whereas cat‐ionic palladium(ii) derivatives applied copolymerization carbon monoxide tert ‐butylstyrene. In addition, palladium tested Heck reaction...
Here we report an optimized protocol for the asymmetric introduction of a fluorine atom into quaternary center facilitated by d-proline, Selectfluor®, and trifluoroethanol. The synthesis proceeds over four steps starting from chiral amino alcohol precursor provides desired enantiomer with no erosion purity good diastereoselectivity. process optimization allowed diastereoselective preparation key intermediate on multigram scale.
The diastereoselective preparation of cis- or trans-4-substituted-4-aminocyclohexyl alcohols by conventional chemical processes reported in the literature requires long synthetic sequences and is not amenable to scale-up. In past decade, ketoreductases (KREDs) have emerged as a powerful approach for chiral secondary from prochiral ketones. This paper describes at kilo scale cis-allyl N-(4-hydroxy-1-methyl-cyclohexyl)carbamate (6a) via ketoreductase transformation. methodology was also...
An automated pipeline for structure determination is outlined that will help unlock the potential of late-stage functionalisation (LSF).
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