A5023829373- Evolutionary Psychology and Human Behavior
- Neuroendocrine regulation and behavior
- Consumer Behavior in Brand Consumption and Identification
- Corneal Surgery and Treatments
- Attachment and Relationship Dynamics
- Behavioral Health and Interventions
- Social and Intergroup Psychology
- Ion Transport and Channel Regulation
- Media Influence and Health
- Cell Adhesion Molecules Research
- Neural and Behavioral Psychology Studies
- Mental Health Research Topics
- Biomedical Research and Pathophysiology
- Death Anxiety and Social Exclusion
- Cytokine Signaling Pathways and Interactions
- Phagocytosis and Immune Regulation
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Genetic Associations and Epidemiology
- Ocular Surface and Contact Lens
- Personality Traits and Psychology
- Renal Diseases and Glomerulopathies
- Nasal Surgery and Airway Studies
- Grief, Bereavement, and Mental Health
- Signaling Pathways in Disease
- Psychology of Social Influence
California State University Los Angeles
2018-2024
University of California, Irvine
2015-2016
Emory University
2013
Duke University
2011-2012
Case Western Reserve University
2003-2011
University of Michigan
2008-2011
University School
2007
MetroHealth Medical Center
2004-2006
Apoptosis results in cell shrinkage and intracellular acidification, processes opposed by the ubiquitously expressed NHE1 Na(+)/H(+) exchanger. In addition to mediating transport, interacts with ezrin/radixin/moesin (ERM), which tethers cortical actin cytoskeleton regulate shape, adhesion, motility, resistance apoptosis. We hypothesize that apoptotic stress activates NHE1-dependent exchange, NHE1-ERM interaction is required for survival signaling. Apoptotic stimuli induced NHE1-regulated as...
Previous studies on dual-brain social interaction have shown different patterns of interpersonal neural synchronization (INS) between conflictual and supportive interactions, but the role emotion in mechanisms such interactions is not well understood. Furthermore, little known about how are affected by relationship type (e.g., romantic vs. friendship) mode verbal nonverbal). To elaborate these issues, this study used functional near-infrared spectroscopy to collect hemodynamic signals from...
Renal tubular epithelial cell (RTC) apoptosis causes atrophy, a hallmark of renal disease progression. Apoptosis is generally characterized by reduced volume and cytosolic pH, but cells are relatively resistant to shrinkage due regulatory increase, which mediated Na + /H exchanger (NHE) 1. We investigated whether RTC requires caspase cleavage NHE1. Staurosporine- hypertonic NaCl-induced was associated with diminished potentiated amiloride analogs, suggesting NHE1 activity opposes apoptosis....
Purpose: Currently, there are no definitive immunomarkers for epithelial stem cells (corneal and conjunctival) or their poorly understood niche microenvironment. The H2B-GFP/K5tTA mouse enables visualization of label-retaining (LRCs), which exhibit the functional marker cell quiescence. We used immunofluorescence tomography to evaluate putative markers LRCs ocular surface. Methods: mice were pulsed 56 days then chased with doxycycline label LRCs. Limbus eyelid tissue was 3-dimensionally...
mFadA and pre‐FadA interaction by transmission electron microscopy (View interaction)
The inner ear is a complex organ containing sensory tissue, including hair cells, the development of which not well understood. Our long-term goal to discover genes critical for correct formation and function its tissue. A novel gene, transmembrane (Tmie), was found cause hearing-related disorders when defective in mice humans. homologous tmie gene zebrafish cloned expression characterized between 24 51 hours post-fertilization. Embryos injected with morpholinos (MO) directed against...
αvβ8 integrin expression is restricted primarily to kidney, brain, and placenta. Targeted αvor β8 deletion embryonic lethal due defective placenta brain angiogenesis, precluding investigation of kidney function. We find that localized glomerular mesangial cells, decreased in mouse models glomerulosclerosis, suggesting regulates normal cell differentiation. To interrogate signaling pathways, yeast two-hybrid co-precipitation studies demonstrated interaction with Rho guanine nucleotide...
Abstract Ghosting, or ignoring someone to end a relationship, is often considered harmful aspect of growing digital connectivity. However, research on ghosting has focused the experiences European/European Americans in romantic contexts. Thus, we broadly explored being ghosted among 29 undergraduates primarily from underrepresented populations (75.9% Latinx, 6.9% Asian, Black) United States. We conducted face‐to‐face semi‐structured interviews regarding general with ghosted, memorable...
Cell fate following Fas (CD95) ligand or agonistic anti-Fas antibody stimulation is determined by multiple factors, including expression level, microdomain localization, and modulating cytokines. Highly expressed clusters activates a canonical apoptosis signaling pathway. In less susceptible cells, transduces apoptosis-independent signals, which are not well defined, but have been linked to inflammation, angiogenesis, fibrosis. To identify pathways, cultured renal tubular epithelial cells...
von Hippel-Lindau (VHL) disease is a cancer syndrome, which includes renal cell carcinoma (RCC), and caused by VHL mutations. Most, but not all phenotypes are due to failure of mutant regulate constitutive proteolysis hypoxia-inducible factors (HIFs). Janus kinases (JAK1, 2, 3, TYK2) promote survival proliferation, processes tightly controlled SOCS proteins, have sequence structural homology VHL. We hypothesized that in disease, RCC pathogenesis results from enhanced SOCS1 degradation,...
Past research on interracial dating has focused demographic and adjustment factors while ignoring the traits most valued in romantic partners. We examined whether intraracial daters differ extent to which they possess various desirable attributes. In Study 1, undergraduates estimated their partners’ ratings of them 27 A factor analysis yielded attractiveness (e.g., physically attractive), cerebral intelligent), relational compassionate), vibrancy confident) Compared with daters, reported...
Catechol-O-methyltransferase (COMT) and brain-derived neurotrophic factor (BDNF) genes have been found to interactively influence working memory (WM) as well brain activation during WM tasks. However, whether the two interactive effects on resting-state activities of these spontaneous activations correlate with are still unknown. This study included behavioral data from tasks genetic (COMT rs4680 BDNF Val66Met) 417 healthy Chinese adults fMRI 298 them. Significant COMT were for performance...
Background Strains from a collection of Drosophila GFP protein trap lines express in the normal tissues where endogenous is present. This can be used to screen for proteins distributed nucleus non-uniform pattern. Methodology/Principal Findings We analyzed four that show peripheral or punctate nuclear staining. One these affects an uncharacterized gene named CG11138. The CG11138 shows distribution periphery similar insulator but does not co-localize with known insulators. Interestingly,...
Abstract Ghosting has become commonplace beyond romantic relationships. Therefore, we aimed to broadly understand ghosters' (i.e., people who ghost others) experiences including the process of ghosting, reasons and attributions for feelings behaviors associated with attitudes toward ghosting. Thirty‐four undergraduates (65% Latinx, 15% Asian, 12% Black, 8% Other ethnicity) had ghosted another person were interviewed in‐person about their ghosting attitudes, behaviors, a memorable experience....
In Western culture, both pop theory and recent behavioral research support the "nice guy stereotype," suggesting that communal qualities emphasize caring for others may be unattractive in men. Few studies, however, have examined initial attractiveness of personality other cultures through methods than self-report. We tested associations between personal attributes (i.e., attributes, social desirability, self-esteem, narcissism) speed-dating success ratings mate desirability) among young...
Several studies have identified inconsistencies between “stated” interpersonal attitudes and those “revealed” after an interaction. The authors used the speed-dating paradigm to examine stated revealed in ingroup preferences among Asian American subgroups (Chinese, Korean, Vietnamese, Filipino Americans). Young single Americans ( n = 198) reported for dating different ethnicities went on speed dates, which they could offer second dates their partners. As expected, all four ethnic showed...
The amygdala plays a critical role in emotion processing and psychiatric disorders associated with dysfunction. Accumulating evidence suggests that structure is modulated by serotonin-related genes. However, there gap between the small contributions of single loci (less than 1%) reported 63-65% heritability structure. To understand "missing heritability," we systematically explored contribution serotonin genes on at gene set level. present study 417 healthy Chinese volunteers examined 129...
Abstract Previous findings on the effects of partner feedback (about self) have been mixed, potentially due to moderating roles individuals' prior well‐being and type attributes appraised. This experimental study 118 college‐student couples examined whether depressive symptoms moderated responses that was either enhancing or verifying social (communion‐related) personal (agency‐related) attributes. Results showed individuals with fewer reported higher relationship quality after receiving...