A5022603186- Hematopoietic Stem Cell Transplantation
- Mesenchymal stem cell research
- Acute Myeloid Leukemia Research
- Immune Response and Inflammation
- Neonatal Respiratory Health Research
- Immunotherapy and Immune Responses
- Oral health in cancer treatment
- Food Allergy and Anaphylaxis Research
- Cancer Cells and Metastasis
- Drug-Induced Adverse Reactions
- Parvovirus B19 Infection Studies
- Mitochondrial Function and Pathology
- Viral-associated cancers and disorders
- Acute Lymphoblastic Leukemia research
- Pediatric health and respiratory diseases
- Hematological disorders and diagnostics
- Autophagy in Disease and Therapy
- Sirtuins and Resveratrol in Medicine
- Endoplasmic Reticulum Stress and Disease
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- Folate and B Vitamins Research
- Contact Dermatitis and Allergies
- Childhood Cancer Survivors' Quality of Life
- Lymphatic System and Diseases
Memorial Ankara Hospital
2025
Bilkent University
2023-2024
Ankara Bilkent City Hospital
2023
Ministry of Health
2014-2020
Sağlık Bilimleri Üniversitesi
2017-2019
Düzce Üniversitesi
2017
Abstract Bone marrow mesenchymal stromal cells (BM-MSCs) are integral components of the bone microenvironment, playing a crucial role in supporting hematopoiesis. Recent studies have investigated potential involvement BM-MSCs pathophysiology acute lymphoblastic leukemia (ALL). However, exact contribution to progression remains unclear because conflicting findings and limited characterization. In this study, we compared derived from pediatric ALL patients with those matched healthy donors...
Granulocyte colony stimulating factor (G-CSF) is sometimes administered to donors before bone marrow (BM) harvest. G-CSF-primed (G-BM) and unprimed BM (U-BM)-derived mesenchymal stem cells (MSC) were obtained from 16 healthy expanded in vitro. Their proliferative characteristics, morphology, differentiation capacity examined. Supernatants of the second passage MSCs evaluated for transforming growth β1, hepatocyte factor, prostaglandin E2 (PGE2) levels compared with controls. The analyses...
Angiogenesis have implications in leukemia biology. Angiopoietin 1 (Ang 1) is an angiogenic cytokine which essential survival and proliferation of endothelial cells. 2 2) promotes dissociation pericytes increases vascular permeability stromal derived factor alpha (SDF 1α) a key player stem cell traffic the bone marrow (BM), has stimulating effects on angiogenesis as well. Here, we investigated role leukemic BM microenvironment specifically, SDF 1α-CXCR4 Ang 1/Ang 2-Tie axes.Here, 1, 2, 1α...
Abstract Iron and vitamin B12 deficiencies are two of the most common diseases in childhood group. Deficiencies iron affect many systems body. In this study, to discover effects on hematopoietic stem cells, we studied CFU assay from peripheral blood. One hundred children were included our study evaluated five categories: deficiency, deficiency anemia, controls. As a result statistical analysis, no significant difference was detected between groups terms assays. The results suggest that,...
Objective: Cancer is a pervasive disease characterized by its widespread occurrence and challenging treatment process. While numerous agents, including viruses, have been identified as potential causes of cancer in both adults children, the complete pathogenesis cancers remains incompletely elucidated. This study aimed to examine presence four viral namely Human T-cell Lymphotropic Virus Type 1 (HTLV-1), Epstein-Barr (EBV), Kaposi's Sarcoma- Associated Herpesvirus (KSHV), Parvovirus B19 (HPV...
Hematopoetic Stem Cell Transplantation (HSCT) has benefical effects for the treatment of leukemia but one adverse effect is Graft versus Host Disease (GVHD) that causes high mortality and morbidity. Mesenchymal Cells (MSCs) are promising tools which used steroid refractory GVHD. The success cellular therapies depends on so many factors associated with donor host characteristics. We designed a study concerning blood group reagents at different titres can affect survival MSCS in as they were...
Acute lymphoblastic leukemia (ALL) is the most common cancer type observed in childhood. Bone marrow (BM) microenvironment has significant role both at beginning and progress of leukemic period. Mesenchymal stem cells (MSCs) that make up microenvironment, regulate growth factors, cytokines induction survival ALL by generating intracellular signals establishing drug resistance. p97/VCP a protein it responsible for also ubiquitin proteasome pathway, endoplasmic-reticulum-associated...
Objective: The present study was planned to examine the expression of Toll-like receptors on human marrow-derived mesenchymal stem cells as a result in-vivo exposure granulocyte colony-stimulating factor with or without agonists.
 Materials and Methods: receptor 2, 3, 4 expressions obtained from healthy bone marrow donors exposed were analyzed, untreated served controls. Also, stimulated in-vitro by agonists observe changes in receptors.
 Results: Mesenchymal both unexposed showed...