A5028355102- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Blood Coagulation and Thrombosis Mechanisms
- Cardiovascular Issues in Pregnancy
- Birth, Development, and Health
- Endometriosis Research and Treatment
- Pregnancy-related medical research
- Venous Thromboembolism Diagnosis and Management
- Child and Adolescent Health
- Endometrial and Cervical Cancer Treatments
- Maternal and Perinatal Health Interventions
- Assisted Reproductive Technology and Twin Pregnancy
- Gestational Diabetes Research and Management
- Maternal and fetal healthcare
- Renal and Vascular Pathologies
- Ectopic Pregnancy Diagnosis and Management
- Preterm Birth and Chorioamnionitis
- Reproductive Biology and Fertility
- Angiogenesis and VEGF in Cancer
- Health Literacy and Information Accessibility
- Chemokine receptors and signaling
- Breastfeeding Practices and Influences
- Acute Myocardial Infarction Research
- Global Maternal and Child Health
- Nursing Roles and Practices
University of Warwick
2017-2025
University Hospitals Coventry and Warwickshire NHS Trust
2017-2025
University Hospital Coventry
2017-2024
Coventry (United Kingdom)
2024
Amsterdam University of Applied Sciences
2024
Coventry and Warwickshire Partnership NHS Trust
2023
Amsterdam University Medical Centers
2023
University of Amsterdam
2023
Radboud University Nijmegen
2023
Radboud University Medical Center
2023
During the implantation window, endometrium becomes poised to transition a pregnant state, process driven by differentiation of stromal cells into decidual (DC). Perturbations in this process, termed decidualization, leads breakdown feto-maternal interface and miscarriage, but underlying mechanisms are poorly understood. Here, we reconstructed pathway at single-cell level vitro demonstrate that first mount an acute stress response before emerging as DC or senescent (snDC). In absence immune...
The benefits and harms of early induction labour to reduce shoulder dystocia in fetuses suspected be large for gestational age (LGA) are uncertain. We aimed investigate whether is associated with a reduced risk compared standard care. In this open-label, randomised controlled phase 3 trial, women aged ≥18 years LGA fetus (estimated fetal weight >90th customised percentile) as identified by ultrasound scan between 35 weeks 0 days (35+0 weeks) gestation 38+0 weeks' gestation, recruited from...
Recurrent pregnancy loss (RPL) is associated with the of endometrial mesenchymal stem-like progenitor cells (eMSC). DPP4 inhibitors may increase homing and engraftment bone marrow-derived to sites tissue injury. Here, we evaluated effect inhibitor sitagliptin on eMSC in women RPL, determined impact decidualization, assessed feasibility a full-scale clinical trial.A double-blind, randomised, placebo-controlled trial aged 18 42 years history 3 or more miscarriages, regular menstrual cycles, no...
In pregnancy, resistance of endometrial decidual cells to stress signals is critical for the integrity fetomaternal interface and, by extension, survival conceptus. O-GlcNAcylation an essential posttranslational modification that links glucose sensing cellular resistance. Unexpectedly, decidualization primary stromal (EnSCs) was associated with a 60% reduction in O-linked β-N-acetylglucosamine (O-GlcNAc)‒modified proteins, reflecting downregulation enzyme adds O-GlcNAc substrates (O-GlcNAc...
BackgroundPregnancies with large-for-gestational-age fetuses are at increased risk of adverse maternal and neonatal outcomes. There is uncertainty about how to manage birth in such pregnancies. Current guidelines recommend a discussion women the pros cons options, including expectant management, induction labor, cesarean delivery. For make an informed decision birth, antenatal detection large for gestational age essential.ObjectiveTo investigate ability ultrasound scans predict birth.Study...
The cost-effectiveness of early induction labour for suspected large-for-gestational-age foetuses to prevent shoulder dystocia is unknown. A within-trial economic evaluation at 38 + 0 4 weeks' gestation foetuses. Resource use and costs were measured 6 months postpartum. We estimated incremental cost per case prevented maternal quality-adjusted life year (QALY) gained. collected data planned caesarean sections in a cohort study. Mean combined woman infant the arm £89 (95% confidence interval...
Introduction Large-for-gestational age (LGA) fetuses have an increased risk of shoulder dystocia. This can lead to adverse neonatal outcomes and death. Early induction labour in women with a fetus suspected be macrosomic may mitigate the The Big Baby Trial aims find if at 38 +0 –38 +4 weeks’ gestation, pregnancies LGA fetuses, reduces incidence Methods analysis is multicentre, prospective, individually randomised controlled trial gestation vs standard care as per each hospital trust (median...
(Abstracted from Lancet 2023;402:54–61) Inherited thrombophilia is implicated as a cause of recurrent pregnancy loss, defined the loss 2 or more pregnancies. Heparin standard treatment for acquired but not recommended in cases and inherited thrombophilia.
Full dilatation caesarean sections (CS) have increased risk of uterine extensions, which leads to cervical trauma that has been associated with an spontaneous preterm birth (sPTB) in a subsequent pregnancy. The aim this study was determine if CS at full the sPTB pregnancy our unit. A historical cohort performed on women delivered by emergency between 2008–2015 (n = 5808) university hospital who had time frame 1557). Women were classified into two exposure groups; those 6–9 cm and fully...
Abstract Breakdown of the feto-maternal interface in early pregnancy causes miscarriage. The cycling endometrium becomes poised to transition a pregnant state during midluteal implantation window, coinciding with differentiation stromal cells into decidual (DC) and emergence senescent (snDC). Emerging evidence suggests that DC engage uterine natural killer eliminate their counterparts, thus enabling formation robust matrix pregnancy. To examine if failure constrain snDC peri-implantation...
ABSTRACT Thrombophilia has been implicated in the cause of recurrent miscarriage, which affects approximately 3% couples trying to conceive. International professional guidelines recommend heparin anticoagulation for antiphospholipid syndrome, an acquired thrombophilia responsible 15% but not other inherited thrombophilias due absence evidence. Many clinicians prescribe women with miscarriage and despite recommendations. This international, open-label, randomized controlled trial aimed...
We present a case of fetal persistent left superior vena cava (PLSVC). A 34-year-old primigravida underwent successful round in vitro fertilisation. She was normally fit and well, the only medical history to note loop excision transformation zone six years prior pregnancy. had normal booking bloods low risk Trisomy screening. However, her PAPP-A MoM came back at 0.21. At twenty week anomaly scan she found have an abnormal four chamber heart view, so referred medicine department where...
The incidence of morbidly adherent placenta is rising secondary to the increasing Caesarean rate and advancing maternal age. Royal College Obstetricians Gynecologists (RCOG) recommends that women with an anterior low a section scar at 32 completed weeks gestation undergo further imaging either ultrasonography and/or magnetic resonance (MRI) distinguish if there likely accreta. aim this audit was determine correlated clinical findings in our unit. Patients were identified from fetal medicine...