A5101868030- Phytase and its Applications
- Cancer-related molecular mechanisms research
- Phytoestrogen effects and research
- Genomics and Phylogenetic Studies
- Glycosylation and Glycoproteins Research
- RNA and protein synthesis mechanisms
- Signaling Pathways in Disease
- Phytochemical compounds biological activities
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Congenital Heart Disease Studies
- Food and Agricultural Sciences
- Mycobacterium research and diagnosis
- Iron Metabolism and Disorders
- Ruminant Nutrition and Digestive Physiology
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Folate and B Vitamins Research
- Cardiac Fibrosis and Remodeling
- Cardiomyopathy and Myosin Studies
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Congenital heart defects research
- Insect Utilization and Effects
- Nanoparticles: synthesis and applications
State Key Laboratory of Pharmaceutical Biotechnology
2024
Nanjing University
2024
Minzu University of China
2023
State Ethnic Affairs Commission
2023
Vanderbilt University Medical Center
2023
Yangzhou University
2018-2020
Henan Agricultural University
2009
Escherichia coli (E. coli) F18 is the main pathogen responsible for post-weaning diarrhea (PWD) in piglets. Resistance to E. depends on expression of cognate receptors intestinal epithelial cells. However, molecular mechanism resistance weaned piglets remains unclear. Here, we performed a comparative transcriptome study duodenal tissue from Sutai sensitive and resistant pigs by RNA-seq, pig α(1,2) fucosyltransferase 2 (FUT2) was identified as host differentially expressed gene controlling...
Porcine epidemic diarrhea virus (PEDV) is currently detected as the main pathogen causing severe in pig farms. The phenotypic alterations induced by pathogenic infections are usually tightly linked with marked changes epigenetic modification and gene expression. We performed global mapping of H3K4 trimethylation (H3K4me3) transcriptomic analyses jejunum PEDV-infected healthy piglets using chromatin immunoprecipitation sequencing RNA-seq techniques. A total 1885 H3K4me3 peaks that associated...
Cardiac fibroblasts are a major source of cardiac fibrosis during heart repair processes in various diseases. Although it has been shown that become senescent response to injury, is unknown how the senescence regulated vivo. Gata4, cardiogenic transcription factor essential for development, also expressed fibroblasts. However, remains elusive about role Gata4 To define fibroblasts, we generated fibroblast-specific knockout mice by cross-breeding Tcf21-MerCreMer with Gata4fl/fl mice. Using...
This study evaluated the effect of fermented soybean meal (FSBM) supplementation on growth performance, meat quality, blood biochemical parameters, and fecal microflora finishing pigs. Thirty-two crossbred pigs (Duroc × Landrance Yorkshire) (66-day-old, 67.95±0.25 kg) were randomly allocated to two treatments fed diets containing FSBM. The average daily gain (ADG), feed intake (ADFI), conversion ratio (FCR), quality index measured. At end experiment, [...]
DNA methylation is an important mediator of gene expression regulation and has been shown to be closely linked aging. Immune-related genes tend influenced by at different ages. To explore changes in the porcine TNFα analyze their potential effects on expression, we measured level promoter mRNA spleen Meishan piglets six developmental stages (1, 7, 14, 21, 28 35 days old) bisulfite sequencing PCR quantitative PCR. The results revealed a trend for increase decrease with age. Correlation...
Phytase and phytase gene from Aspergillus ficuum ( A. ) were used in this study. The results showed that activity reached the peak of 0.17 U/g after 4 d incubation solid medium for ; optimum pH temperature 2.5 50 oC, respectively. A 1.4-kb DNA containing coding region was isolated inserted into expression vectors pIAβ8 pGAPZαA, which transformed E. coli (Top 10). maximal activities supernatant cells 2.31 9.04 U/ml with pIAβ8, 8.04 2.93 It concluded recombinant pIAβ8-phytase could express...