A5052000422- Cardiac, Anesthesia and Surgical Outcomes
- Gastrointestinal Tumor Research and Treatment
- Anesthesia and Pain Management
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Bipolar Disorder and Treatment
- Anesthesia and Sedative Agents
- Health disparities and outcomes
- Climate Change and Health Impacts
- Mental Health Research Topics
- HER2/EGFR in Cancer Research
- Health, Environment, Cognitive Aging
- Organ Donation and Transplantation
- Digital Mental Health Interventions
- Renal Transplantation Outcomes and Treatments
- Liver Disease Diagnosis and Treatment
- Circadian rhythm and melatonin
- Lung Cancer Treatments and Mutations
- Machine Learning in Healthcare
- Pregnancy-related medical research
- Pain Management and Opioid Use
- Lipoproteins and Cardiovascular Health
- Aging and Gerontology Research
- Neurological Complications and Syndromes
- Opioid Use Disorder Treatment
Korea University
2012-2024
Chungnam National University Hospital
2021-2022
Chungnam National University
2022
Seoul National University Bundang Hospital
2019
Cancer Research And Biostatistics
2019
Disturbances in circadian rhythms have been suggested as a possible cause of bipolar disorder (BD). Included this study were 31 mood episodes 26 BD patients, and 18 controls. Circadian evaluated at admission, 2-week intervals during hospitalization, discharge. All participants wore wrist actigraphs the studies. Saliva buccal cells obtained 8:00, 11:00, 15:00, 19:00, 23:00 for two consecutive days. Collected saliva used analysis cortisol gene rhythm, respectively. had different phases acute...
This study aimed to investigate the degree of occupational stress and clinical mental state dentists. In addition, we investigated correlation with depression, anxiety, sleep among dentists in Korea. A cross-sectional survey on 231 was conducted using Doctor Job Stress Scale, Center for Epidemiologic Studies Depression Scale (CES-D), State-Trait Anxiety Index (STAI), Pittsburgh Sleep Quality (PSQI). Correlation health by adjusted multiple regression analysis. The scores CES-D, STAI, PSQI...
Objective Previous studies have indicated that suicide rates significant seasonal variations. There is discordance between temperature and solar radiation due to the monsoon season in South Korea. We investigated seasonality of assessed its association with climate variables Method Suicide were obtained from National Statistical Office Korea, climatic data Korea Meteorological Administration for period 1992–2010. conducted analyses using a generalized additive model ( GAM ). First, we...
Smartphones and wearable devices can be used to obtain diverse daily log data related circadian rhythms. For patients with mood disorders, giving feedback via a smartphone app appropriate behavioral correction guides could play an important therapeutic role in the real world.We aimed evaluate effectiveness of named Circadian Rhythm for Mood (CRM), which was developed prevent episodes based on machine learning algorithm that uses passive digital phenotype rhythm behaviors obtained activity...
HT042 is a standardized functional food ingredient approved by Korean Food and Drug Administration with claim ‘HT042 can help height growth of children’. We aimed to evaluate the safety efficacy on in children mild short stature. A multicenter, randomized, double‐blind, placebo‐controlled parallel study was performed aged 6–8 years ranked below 25th percentile. In 129 children, gain significantly higher group than placebo after 24 weeks (mean difference, 0.29 cm; 95% CI, 0.01 0.57 p =...
The applicability of the in vivo proton magnetic resonance spectroscopy hepatic lipid profiling (MR-HLP) technique nonalcoholic fatty liver disease was investigated. Using spectroscopy, relative fractions diunsaturated (fdi), monounsaturated (fmono), and saturated (fsat) acids as well total content were estimated livers 8 control 23 CCl4-treated rats at 9.4 T. mean steatosis, necrosis, inflammation, fibrosis scores treated group all significantly higher than those (P < 0.01). There a strong...
Abstract There have been concerns about abuse and unnecessary chronic administration of zolpidem, zolpidem’s relation to suicide risk. To investigate the temporal association zolpidem with risk suicide, we conducted a 12-year, population-based, retrospective cohort study on National Health Insurance Service–National Sample Cohort (NHIS-NSC), South Korea. Data were collected from 2002 2013 NHIS-NSC, data cleaning was performed for 1,125,691 subjects. Cox proportional hazards regression...
Abstract Background Although recipients and donors in living kidney transplantation experience psychological distress—including depression anxiety—during the pre-operative period, very few studies have evaluated related reactions. This study aimed to determine characteristics correlations of mood states personality (genetically unrelated) transplantations. Methods A total 66 pairs were enrolled from April 2008 June 2019 this study, whom 53 eligible included retrospective analysis their...
Background: Ramucirumab as monotherapy or in combination with paclitaxel is a second-line treatment option recommended for patients locally advanced unresectable metastatic gastric gastroesophageal junction (GEJ) adenocarcinoma. However, real-world data from large study cohorts focused on ramucirumab plus cancer are limited. Methods: The population comprised all GEJ who received South Korea between 1 May 2018 and 31 December 2018. We included adenocarcinoma disease progression after...
Abstract Curative treatments for very early-stage hepatocellular carcinoma (HCC), defined as single HCC with a maximum diameter of <2 cm in patients well-preserved liver function, consist surgical resection or radiofrequency ablation (RFA). In this retrospective study, we compared the efficacy both 154 HCCs who underwent RFA initial therapy and were followed up median 56.8 months. Propensity score matching analysis was also conducted. Overall survival comparable between treatment groups...
This study aimed to examine the association between preadmission statin use and 90-day mortality in critically ill patients investigate whether this differed according type dose. We hypothesized that was associated with lower mortality.This retrospective cohort analyzed medical records of all adult admitted intensive care unit a single tertiary academic hospital January 2012 December 2017. Data including use, subtype, daily dosage were collected, associations these variables after admission...
Purpose: This study aimed to investigate clinical practices and factors related the outcomes of T-DM1 use in patients with HER2-positive metastatic breast cancer (mBC). Methods: We included mBC who received as a palliative therapy between August 2017 December 2018. The safety T-DM1, including overall response rate (ORR), progression-free survival (PFS), (OS), were evaluated. A Cox proportional hazards model was used estimate hazard ratio 95% confidence interval (CI) for mortality or...
Background: Electronic medical records (EMRs) have the highest value among real-world data (RWD). The aim of present study was to propose a collection framework EMR-based RWD evaluate effectiveness and safety cancer drugs by conducting nationwide based on Korean Cancer Study Group. Methods: We considered all patients who received ramucirumab plus paclitaxel (RAM/PTX) for gastric trastuzumab emtansine (T-DM1) breast at relevant institutions in South Korea. Standard operating procedures...
We aimed to investigate the association between body mass index (BMI) at time of intensive care unit (ICU) admission and 90-day mortality risk in complete-case datasets that ignore missing data as well with multiple imputation for data.This retrospective study analysed medical records adult patients admitted ICUs a single tertiary academic hospital. For BMI analysis, were classified into four groups: underweight (<20 kg/m2 ), normal (20-24.9 overweight (25-29.9 obese (≥30 ).A total 24,928...
4056 Background: Ramucirumab as monotherapy or in combination with paclitaxel is a second-line treatment option recommended for patients locally advanced unresectable metastatic gastroesophageal junction (GEJ) gastric adenocarcinoma. However, real-world data of large samples focused on ramucirumab plus cancer are limited. We conducted nationwide retrospective study to evaluate the efficacy, safety, and factors potentially associated survival GEJ adenocarcinoma who received setting. Methods:...
e18759 Background: Electronic medical record (EMRs) have the highest reliability among real-world data (RWD), but controlling for biases that may affect study outcomes remains challenging. This aimed to establish a collection framework of EMR-based RWD evaluate effectiveness and safety cancer drug by conducting nationwide based on Korean Cancer Study Group. Methods: We selected ramucirumab plus paclitaxel (RAM/PTX) trastuzumab-emtansine (T-DM1), which are currently used treat advanced...
<sec> <title>BACKGROUND</title> Smartphones and wearable devices can be used to obtain diverse daily log data related circadian rhythms. For patients with mood disorders, giving feedback via a smartphone app appropriate behavioral correction guides could play an important therapeutic role in the real world. </sec> <title>OBJECTIVE</title> We aimed evaluate effectiveness of named Circadian Rhythm for Mood (CRM), which was developed prevent episodes based on machine learning algorithm that...
EBioMedicine 11 (2016) 285–295 Contents lists available at ScienceDirect journal homepage: www.ebiomedicine.com Research Paper Advanced Circadian Phase in Mania and Delayed Mixed Depression Returned to Normal after Treatment of Bipolar Disorder Joung-Ho Moon M.S. a,b,1 , Chul-Hyun Cho M.D., Ph.D. a,1 Gi Hoon Son c Dongho Geum b Sooyoung Chung d Hyun Kim e Seung-Gul Kang f Young-Min Park g Ho-Kyoung Yoon a Leen Hee-Jung Jee h Hyonggin An Daniel.F. Kripke M.D. i Heon-Jeong Lee a,b, ⁎ Dept....