A5015859763- Fungal and yeast genetics research
- Per- and polyfluoroalkyl substances research
- Wnt/β-catenin signaling in development and cancer
- Toxic Organic Pollutants Impact
- Birth, Development, and Health
- 14-3-3 protein interactions
- Protein Kinase Regulation and GTPase Signaling
- Aquatic life and conservation
- Microtubule and mitosis dynamics
- Cancer-related gene regulation
- Aquaculture Nutrition and Growth
- Aquaculture disease management and microbiota
- Yeasts and Rust Fungi Studies
- Microplastics and Plastic Pollution
- Effects and risks of endocrine disrupting chemicals
- biodegradable polymer synthesis and properties
- Marine Biology and Environmental Chemistry
- Gut microbiota and health
- Polyamine Metabolism and Applications
- Folate and B Vitamins Research
Jiangxi Academy of Sciences
2020-2022
Jiangxi Normal University
2020
Jilin Agricultural Science and Technology University
2013
Jilin Agricultural University
2013
The University of Texas MD Anderson Cancer Center
1999-2003
Perfluorooctane sulfonate (PFOS) has been reported to induce hepatotoxicity in wildlife and humans. Novel PFOS alternatives have widely used following restrictions on PFOS, but little is known about their potential toxicity. Here, the first comprehensive investigation chronic underlying molecular mechanisms of 6:2Cl-PFESA (F-53B), sodium p-perfluorous nonenoxybenzene (OBS) was carried out adult zebrafish through a histopathological examination, biochemical measurement, multi-omics analysis....
The Ste20/p21-activated kinase homolog Shk1 is essential for viability and required normal morphology, mating, cell cycle control in the fission yeast Schizosaccharomyces pombe. regulated by p21 G protein Cdc42, which has been shown to form a complex with SH3 domain Scd2 (also called Ral3). In this study, we investigated whether plays role regulating function. We found that recombinant interact directly vitro they vivo, as determined two-hybrid assay genetic analyses yeast. second of two...
The p21-activated kinase (PAK) homolog, Shk1, is a critical component of multifunctional Ras/Cdc42/PAK complex required for viability, polarized growth and cell shape, sexual differentiation in the fission yeast, Schizosaccharomyces pombe. Substrate targets Shk1 have not previously been described. Here we show that S. pombe polarity factor, Tea1, directly phosphorylated by vitro. We demonstrate further Tea1 cells its level phosphorylation significantly reduced defective function. Consistent...
Summary The p21‐activated kinase, Shk1, is required for the proper establishment of cell polarity in fission yeast, Schizosaccharomyces pombe . We showed recently that loss essential Shk1 inhibitor, Skb15, causes significant spindle defects thus implicating as a potential regulator microtubule dynamics. Here, we show cells deficient function have malformed interphase microtubules and mitotic spindles, are hypersensitive to microtubule‐destabilizing drug thiabendazole (TBZ) cold sensitive...
The p21-activated kinase (PAK) homolog Shk1 is essential for cell viability in the fission yeastSchizosaccharomyces pombe. Roles have been established regulation of morphology, sexual differentiation, and mitosis S. In this report, we describe genetic molecular characterization a novel SH3 domain protein, Skb5, identified as result two-hybrid screen interacting proteins. pombe cells carrying deletion skb5 gene exhibit no discernible phenotypic defects under normal growth conditions, but when...