A5020897992- Tryptophan and brain disorders
- Cannabis and Cannabinoid Research
- Stress Responses and Cortisol
- Epigenetics and DNA Methylation
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- Neurotransmitter Receptor Influence on Behavior
- Treatment of Major Depression
- Prenatal Substance Exposure Effects
- Anesthesia and Neurotoxicity Research
- Biochemical effects in animals
- Bipolar Disorder and Treatment
- Memory and Neural Mechanisms
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Neurogenesis and neuroplasticity mechanisms
- Birth, Development, and Health
- Autism Spectrum Disorder Research
- Pain Mechanisms and Treatments
- Medicinal Plant Extracts Effects
- Electroconvulsive Therapy Studies
- Diet, Metabolism, and Disease
- Receptor Mechanisms and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
Universidade de São Paulo
2015-2024
Universidade de Ribeirão Preto
2019-2020
Clinics Hospital of Ribeirão Preto
2014-2016
BACKGROUND AND PURPOSE Epigenetic modifications are thought to play an important role in the neurobiology of depression. Antidepressant treatment induces histone acetylation hippocampus, which is associated with transcriptional activation, whereas stress increases DNA methylation, repression. Because specific involvement methylation regulation depressive‐like behaviours not yet known, we have investigated effects induced by systemic or intra‐hippocampal administration inhibitors...
Cannabidiol (CBD) is a compound of Cannabis sativa with relevant therapeutic potential in several neuropsychiatric disorders including depression. CBD treatment has shown significant antidepressant-like effects different rodent preclinical models. However, the mechanisms involved CBD-induced antidepressant are still poorly understood. Therefore, this work aimed at investigating participation serotonin (5-HT) and/or noradrenaline (NA) forced swimming test (FST) by: 1) testing if...
Objective Stress increases DNA methylation and decreases the expression of genes involved in neural plasticity, while treatment with methyltransferase inhibitors (DNMTi) gene induces antidepressant-like effects preclinical models. Therefore, aim present work was to further investigate potential effect induced by DNMTi evaluating behavioural associating conventional antidepressant drugs mice submitted forced swimming test (FST). In addition, brain levels were also investigated. Methods Mice...
Chronic pain increases the risk of developing anxiety, with limbic areas being likely neurological substrates. Despite high clinical relevance, little is known about precise behavioral, hormonal, and brain neuroplastic correlates anxiety in context persistent pain. Previous studies have shown that decreased nociceptive thresholds chronic models are paralleled by anxiety-like behavior rats, but there conflicting ideas regarding its effects on stress response circulating corticosterone levels....
Systemic as well hippocampal administration of nNOS inhibitors induces antidepressant-like effects in animal models. However, the mechanisms underlying these have not been completely understood. Evidence has suggested that inhibition increases serotonin signaling brain. Moreover, activation prosencephalic 5HT1A receptors is considered to mediate stress coping and antidepressant effects. On this basis, aim study was investigate hypothesis effect induced by dorsal hippocampus (DH) would...
Epigenetic mechanisms such as DNA methylation (DNAm) have been associated with stress responses and increased vulnerability to depression. Abnormal DNAm is observed in stressed animals depressed individuals. Antidepressant treatment modulates levels regulates gene expression diverse tissues, including the brain blood. Therefore, could be a potential therapeutic target Here, we reviewed current knowledge about involvement of behavioural molecular changes exposure We also evaluated possible...
Background: Cannabidiol is a non-psychotomimetic compound with antidepressant-like effects. However, the mechanisms and brain regions involved in cannabidiol effects are not yet completely understood. Brain-derived neurotrophic factor/tropomyosin-receptor kinase B/mammalian target of rapamycin (BDNF-TrkB-mTOR) signaling, especially limbic structures, seems to play central role mediating antidepressant drugs. Aim: Since it known if BDNF-TrkB-mTOR signaling hippocampus critical cannabidiol, we...
Depending on its duration and severity, stress may contribute to neuropsychiatric diseases such as depression anxiety. Studies have shown that impacts the hypothalamic–pituitary–adrenal (HPA) axis, but downstream molecular, behavioral, nociceptive effects remain unclear. We hypothesized a 2-hour single exposure acute restraint (ARS) activates HPA axis changes DNA methylation, molecular mechanism involved in machinery of regulation. further ARS induces anxiety-like risk assessment behavior...
Systemic or hippocampal administration of nitric oxide (NO) synthase inhibitors induces antidepressant-like effects in animals, implicating increased levels NO the neurobiology depression. However, role played by different this process has not been clearly defined. As stress is able to induce neuroinflammatory mechanisms and trigger expression inducible (iNOS) brain, as well upregulate neuronal (nNOS) activity, aim present study was investigate possible differential contribution iNOS nNOS...
It has been postulated that the activation of NMDA receptors (NMDAr) and nitric oxide (NO) production in hippocampus is involved behavioral consequences stress. Stress triggers NMDAr-induced calcium influx limbic areas, such as hippocampus, which turn activates neuronal NO synthase (nNOS). Inhibition nNOS or NMDAr activity can prevent stress-induced effects animal models, but molecular mechanisms behind this effect are still unclear. In study, cultured hippocampal neurons treated with...