A5069533942- Cannabis and Cannabinoid Research
- Neurotransmitter Receptor Influence on Behavior
- Tryptophan and brain disorders
- Autism Spectrum Disorder Research
- Sleep and Wakefulness Research
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Schizophrenia research and treatment
- Diet, Metabolism, and Disease
- Biochemical effects in animals
- Pancreatic function and diabetes
- Stress Responses and Cortisol
- GABA and Rice Research
- Pharmacological Receptor Mechanisms and Effects
- Pain Mechanisms and Treatments
- Occupational Health and Burnout
- Phytochemistry Medicinal Plant Applications
- Phosphodiesterase function and regulation
- Prenatal Substance Exposure Effects
- Gut microbiota and health
- Neuropeptides and Animal Physiology
- Coffee research and impacts
- Hydrogen's biological and therapeutic effects
- Psychedelics and Drug Studies
- Epigenetics and DNA Methylation
Universidade de São Paulo
2013-2024
Clinics Hospital of Ribeirão Preto
2018-2024
Hospital Universitário da Universidade de São Paulo
2024
Instituto de Neurociências e Comportamento
2023
Universidade de Ribeirão Preto
2014
Cannabidiol (CBD) is a major Cannabis sativa constituent, which does not cause the typical marijuana psychoactivity. However, it has been shown to be active in numerous pharmacological assays, including mice tests for anxiety, obsessive-compulsive disorder, depression and schizophrenia. In human trials doses of CBD needed achieve effects anxiety schizophrenia are high. We report now synthesis 3 fluorinated derivatives, one which, 4'-F-CBD (HUF-101) (1), considerably more potent than...
L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia is a side effect of Parkinson's disease treatment and it characterized by atypical involuntary movements. A link between neuroinflammation L-DOPA-induced has been documented. Hydrogen gas (H2) neuroprotective effects in models major anti-inflammatory effect. Our objective to test the hypothesis that H2 inhalation reduces dyskinesia. 15 days after 6-hydroxydopamine lesions dopaminergic neurons were made (microinjection into medial...
Pharmacological manipulation of nitric oxide (NO) has been suggested as a promising treatment for schizophrenia symptoms. A single infusion sodium nitroprusside, NO donor with short half-life, was found to improve However, an increasing number preclinical studies have demonstrated the potential beneficial effects both donors and inhibitors. We investigated synergistic effect sub-effective doses nitroprusside or inhibitor 7-Nitroindazole (7NI) combined clozapine, standard atypical...
O canabidiol, fitocanabinóide presente na planta Cannabis sativa é desprovido dos efeitos psicotomiméticos característicos do principal composto da Cannabis, o ∆9-tetraidrocanabinol, mais conhecido como delta 9-THC. Um conjunto crescente de evidências sugere que canabidiol apresente potencial terapêutico para tratamento sintomas distúrbios psiquiátricos, a depressão, ansiedade e as psicoses. A observação em humanos, mas também modelos animais experimentais capacidade antagonizar os 9-THC...
<title>Abstract</title> The role of 5-lipoxygenase/leukotrienes on the central nervous system has been considered in both physiological end pathological states. Investigating interaction between and dopaminergic may provide better understanding dopamine-related pathologies. This study aimed to investigate motor non-motor responses 5-lipoxygenase/leukotrienes-deficient mice. Pharmacological challenges included amphetamine, apomorphine reserpine treatment along with their respective effects...
Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders whose symptoms include impaired communication and social interaction, stereotypies, varying levels intellectual disability. Together with these are co-occurring psychiatric or neurological conditions, often hyperactivity attention disorders, anxiety, depression, epilepsy. So far, no effective treatment for ASD available, possibly because its neurobiological basis heterogeneous nature not clearly understood. Clinical...