A5011109380- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- HIV-related health complications and treatments
- Long-Term Effects of COVID-19
- HIV Research and Treatment
- COVID-19 and Mental Health
- Intensive Care Unit Cognitive Disorders
- HIV/AIDS Research and Interventions
- Neurological Disorders and Treatments
- COVID-19 Clinical Research Studies
- Frailty in Older Adults
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Genetics and Neurodevelopmental Disorders
- Palliative Care and End-of-Life Issues
- Chronic Disease Management Strategies
- Anesthesia and Sedative Agents
- Aging and Gerontology Research
- Intergenerational Family Dynamics and Caregiving
- Geriatric Care and Nursing Homes
- Autism Spectrum Disorder Research
- Health and Wellbeing Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Family and Patient Care in Intensive Care Units
- Health, psychology, and well-being
Leicester General Hospital
2018-2025
University of Leicester
2017-2025
Leicestershire Partnership NHS Trust
2018-2025
Leicester College
2025
Imperial College London
2022-2024
University Hospitals of Leicester NHS Trust
2023
NIHR Leicester Biomedical Research Centre
2021-2023
Glenfield Hospital
2021-2023
University of Oxford
2023
National Health Service
2020-2023
Abstract White matter (WM) disease is associated with disruption of the gliovascular unit, which involves breach blood–brain barrier (BBB). We quantified pericytes as components unit and assessed their status in vascular other common dementias. Immunohistochemical immunofluorescent methods were developed to assess distribution quantification connected frontal lobe WM capillaries. Pericytes a nucleus identified by collagen 4 (COL4) platelet‐derived growth factor receptor‐β (PDGFR‐β)...
This study aimed to explore the effects of COVID-19 and lockdown measures adopted in England on patients with acute mental illness.
Iron accumulates in the ageing brain and brains with neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's (PD), Huntington's (HD), Down syndrome (DS) dementia. However, mechanisms of iron deposition regional selectivity are ill-understood. The identification several proteins that involved homeostasis, transport, regulation suggests avenues to explore their function diseases. To uncover molecular underlying this association, we investigated distribution expression these...
Abstract Objective: In some individuals, coronavirus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection leads to a variety of serious inflammatory symptoms, including blood clotting and distress. Death due COVID-19 shows steep rise in relation age. Comorbidities such as type 2 diabetes mellitus (T2DM), hypertension, cardiovascular disease also increase susceptibility. It has been reported that T-cell regulatory dipeptidyl peptidase 4 (DPP4; cluster differentiation 26...
Background Pharmacological treatment of behavioral and psychological symptoms dementia is limited benefit. The addition non-pharmacological interventions often essential for optimal symptom control. Music a viable way to help patients communicate improve their quality life. Objective This study aims find the most effective use music in busy ward. Methods 17 inpatients (aged 63–93 years) with clinical diagnosis Alzheimer's disease took part over five weeks. lyrics presented via free-field...
Abstract Background The overlap between physical and mental health is a common challenge for older adults, many live with co-occurring disorders. Different service models have been adopted; however, the majority provide specialist input to adults needs in acute hospital trusts. Few are available providing comprehensive secondary healthcare settings. Furthermore, little information regarding specific facing people receiving healthcare. aim of this qualitative study was determine facilitators...
Abstract Despite growing attention to well-being in dementia, few studies have defined meaning-based (eudaimonic) this population, mainly due challenges posed by cognitive decline and self-report limitations. We developed validated a novel tool for measuring individuals with particularly those receiving residential or home care. The study included two samples: carers of 174 care residents 420 community-dwelling whom respondents reported dementia. Well-being Dementia Inventory (WiDI) assesses...
The clinical diagnosis and treatment of Alzheimer's disease (AD) represent a challenge to clinicians due the variability symptomatology as well unavailability reliable diagnostic tests. In this study, development novel electrochemical assay its potential detect peripheral blood biomarkers diagnose AD using plasma immunoglobulins is investigated. immunosensor employs gold electrode immobilizing substrate, albumin depleted immunoglobulin biomarker, polyclonal rabbit Anti-human (against IgA,...
Background: Cerebrospinal fluid (CSF) measures of tau and amyloid proteins have now been largely accepted to be a diagnostic tool aid the clinical diagnosis Alzheimer's disease (AD), but CSF is not routinely obtained in most settings. There need, therefore, uncover additional readily accessible peripheral biomarkers that will enable comprehensive detection AD-specific blood derivates. Objectives: Blood platelets contain found neuronal cell lines, including protein. Since protein...
Validated screening tools for HIV-associated neurocognitive disorders (HAND) are lacking the newly emergent ageing population of people living with HIV (PLWH) in sub-Saharan Africa (SSA). We aimed to validate and compare diagnostic accuracy two cognitive tools, International dementia scale (IHDS), Identification Interventions Dementia Elderly Africans (IDEA) screen, identification HAND older PLWH Tanzania. A systematic sample 253 aged ≥ 50 attending a Government clinic Tanzania were screened...