A5069454846- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Multiple Sclerosis Research Studies
- Mesenchymal stem cell research
- Pluripotent Stem Cells Research
- Immune Response and Inflammation
- Autoimmune and Inflammatory Disorders Research
- Amyotrophic Lateral Sclerosis Research
- Exercise and Physiological Responses
- Fibromyalgia and Chronic Fatigue Syndrome Research
- MicroRNA in disease regulation
- Medicinal Plants and Bioactive Compounds
- Cholinesterase and Neurodegenerative Diseases
- Cancer-related molecular mechanisms research
- Lower Extremity Biomechanics and Pathologies
- Circular RNAs in diseases
- Prion Diseases and Protein Misfolding
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Adipose Tissue and Metabolism
- Microtubule and mitosis dynamics
- Neurogenetic and Muscular Disorders Research
- Phosphodiesterase function and regulation
- Urban Green Space and Health
- Mitochondrial Function and Pathology
Ariel University
2014-2024
Hadassah Medical Center
2005-2016
United States Nuclear Regulatory Commission
2010
Center for Neuro-Oncology
2010
Stornoway Historical Society
2010
Hebrew University of Jerusalem
2002-2009
Hadassah Academic College
2007
Abstract Transplanted neural precursor cells remyelinate efficiently acutely demyelinated focal lesions. However, the clinical value of cell transplantation in a chronic, multifocal disease like multiple sclerosis will depend on ability transplanted to migrate foci brain. Here, we expanded newborn rat spheres and them intracerebroventricularly or intrathecally rats. The were labeled by nuclear fluorescent dye Hoechst incubation with BrdU enable their identification at 2 days weeks after...
Abstract Objective Intracerebroventricular or intravenous (IV) injection of neural precursor cells (NPCs) attenuates experimental autoimmune encephalomyelitis (EAE), the animal model multiple sclerosis. Although stem cell therapy was introduced initially for replacement, we examine here whether NPCs possess immunomodulatory effects. Methods We examined effects systemic administration on central nervous system (CNS) inflammation in EAE and interactions between T vitro vivo. Results IV NPC...
Multiple sclerosis (MS) is an immune mediated demyelinating disease of the central nervous system (CNS). A potential new therapeutic approach for MS cell transplantation which may promote remyelination and suppress inflammatory process.We transplanted human embryonic stem cells (hESC)-derived early multipotent neural precursors (NPs) into brain ventricles mice induced with experimental autoimmune encephalomyelitis (EAE), animal model MS. We studied effect NPs on functional pathological...
Gliomas express many genes that play a role in neural precursor cells (NPCs), but no direct comparison between glioma and stem cell (SC) gene expression profiles has been performed. To investigate the similarities differences gliomas SCs, we compared microRNA (miRNA) signatures of glial tumors, embryonic SCs (ESCs), NPCs, normal adult brains from both human mouse tissues. We demonstrated (regardless their grade) methylcholanthrene-induced shared an miRNA profile is reminiscent NPCs. About...
In multiple sclerosis lesions resident oligodendrocyte progenitor cells (OPCs) are present, but fail to remyelinate. the current study we examined whether neural precursor cell (NPC) transplantation can facilitate host brain-derived remyelination. We used chronic cuprizone-induced demyelination model in aged mice, which slow remyelination follows cuprizone removal. NPCs were transplanted lateral ventricles (intracerebroventricular) of demyelinated brains. this experimental setup, remained...
Abstract Neural stem cell (NSC) transplantation has been shown to attenuate the severity of experimental autoimmune encephalomyelitis (EAE), an animal model multiple sclerosis (MS). Central future success NSC in MS is ability transplanted cells migrate from site relevant foci disease. Using magnetically labeled mouse neurospheres and human embryonic (hESC)‐derived neurospheres, we applied serial magnetic resonance imaging (MRI) assess biodynamics migration a chronic EAE model. Magnetic...
Abstract Objectives Misfolding of key disease proteins to an insoluble state is associated with most neurodegenerative conditions, such as prion, Parkinson, and Alzheimer's diseases. In this work, by studying animal models multiple sclerosis, we asked whether also the case for myelin basic protein (MBP) in late phases demyelinating Methods To effect, tested MBP, essential component, present prion‐like properties MS, Cuprizone‐induced chronic demyelination or Experimental Autoimmune...
Neurodegeneration is considered the consequence of misfolded proteins' deposition. Little known about external environmental effects on neurodegenerative process. Infectious agent-derived pathogen-associated molecular patterns (PAMPs) activate microglia, key players in diseases. We hypothesized that systemic microbial pathogens may accelerate neurodegeneration Alzheimer's disease (AD) and microglia play a central role this process.We examined effect an infectious environment Toll-like...
Background : Exercise training induces beneficial effects on neurodegenerative diseases, and specifically multiple sclerosis (MS) it’s model experimental autoimmune encephalomyelitis (EAE). However, it is unclear whether exercise exerts direct protective the central nervous system (CNS), nor are mechanisms of neuroprotection fully understood. In this study, we investigated neuroprotective high-intensity continuous (HICT) against development neuroinflammation role resident microglia. Methods...
Abstract A key issue for therapeutic neural stem cell transplantation in chronic diseases is the long‐term survival of transplanted cells brain. The normal adult central nervous system does not support cells. Presumably, limited availability trophic factors maintains resident but insufficient supporting Specifically, multiple sclerosis, a relapsing disease, it would be necessary to maintain through phases relapses and remissions. It may beneficial transplant as early possible, form that will...
Abstract Fetal neural stem/precursor cells (NPCs) possess powerful immunomodulatory properties which enable them to protect the brain from immune‐mediated injury. A major issue in developing cell (NPC) therapy for chronic neuroinflammatory disorders such as multiple sclerosis is whether maintain their immune‐regulatory prolonged periods of time. Therefore, we studied time‐associated changes NPC properties. We examined intracerebrally‐transplanted NPCs are able inhibit early versus delayed...
Abstract Background Exercise training (ET) has beneficial effects on multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE). However, the intensity‐dependent of ET systemic immune system in EAE remain undefined. Objective (1) To compare modulatory moderate versus high‐intensity protocols protecting against development EAE; (2) investigate whether affects autoimmunity selectively, or causes general immunosuppression. Methods Healthy mice performed treadmill...
The exact etiologies of most neurodegenerative disorders remain poorly understood, therefore hampering the identification molecular targets with clinical therapeutic potential. Recent and experimental evidence supports notion that amino acid metabolism could be implicated in pathophysiology disease progression diseases. This review aims to present common neurological diseases lead axonal degeneration examine potential role metabolism, a particular focus on multiple sclerosis,...
Previous research suggests that acetylcholinesterase (AChE) may be involved in ALS pathogenesis. AChE enzyme inhibitors can upregulate transcription which certain contexts have deleterious (noncatalytic) effects, making them theoretically harmful ALS, whilst antisense-oligonucleotides (mEN101), downregulate beneficial. Our aim was to investigate whether downregulation of using mEN101 is beneficial an mouse model.ALS (G93A-SOD1) mice received saline, mEN101, inverse-EN101, or neostigmine....