Abstract Introduction This study tested the hypothesis that Major Histocompatibility Complex (MHC) incompatible equine mesenchymal stromal cells (MSCs) would induce cytotoxic antibodies to donor MHC antigens in recipient horses after intradermal injection. No studies date have explored antibody responses allogeneic MSC transplantation horse. information is critical because horse a valuable species for assessing safety and efficacy of treatment prior human clinical application. Methods Six...

Abstract Objective —To describe the demographic and clinical characteristics of a population geriatric horses. Design —Retrospective study. Animals —467 horses that were ≥ 20 years age. Procedure —Medical records 539 evaluated at university large animal hospital between 1989 1999 reviewed. Data collected included signalment, reason for evaluation, specific diagnoses, surgical procedures, inpatient or outpatient care, duration hospitalization, outcome. Results met criteria inclusion in Horses...

To describe the demographic and clinical characteristics, management practices, owner perception of a population geriatric horses, to compare these data with findings in group younger horses.Original study.218 horses.Data were collected via survey tool from owners 165 horses that > or = 20 years age 53 < age.Compared young included significantly greater number ponies; also more likely have history colic, dental disease, tumors, lameness, pituitary but not laminitis, diarrhea, allergies,...

Abstract The invasive trophoblast cells of the equine placenta migrate into endometrium to form endometrial cups, dense accumulations that produce chorionic gonadotropin between days 40 and 120 normal pregnancy. mechanisms by which invade while evading maternal immune destruction are poorly defined. A gene expression microarray analysis performed on placental tissues obtained at day 34 gestation revealed a &amp;gt;900-fold upregulation mRNA encoding cytokine IL-22 in girdle relative...

Background Equine herpesvirus type 1 (EHV-1), a member of the Alphaherpesvirinae, is spread via nasal secretions and causes respiratory disease, neurological disorders abortions. The virus significant equine pathogen, but current EHV-1 vaccines are only partially protective effective metaphylactic therapeutic agents not available. Small interfering RNAs (siRNA's), delivered intranasally, could prove valuable alternative for infection control. siRNA's against two essential genes, encoding...

Abstract Objective – To describe the clinical and pathological findings in 2 adult horses with documented increases intra‐abdominal pressure (IAP), to direct puncture technique used measure this pressure. Series Summary Two developed IAP secondary large‐volume abdominal effusion. A 9‐year‐old Quarter Horse cross gelding was presented for evaluation of urinary neurologic signs. Abdominal ultrasonographic examination showed a hepatic abscess along 4‐year‐old castration complications. site...

CASE DESCRIPTION-13 equids (10 horses, 2 donkeys, and 1 pony) were examined for signs of colic (n = 7), weight loss (6), anorexia (3), diarrhea (2). Ten evaluated in the fall (September to November). Seven had a history persimmon ingestion. CLINICAL FINDINGS-A diagnosis phytobezoar caused by ingestion was made all equids. Eight gastric phytobezoars; 5 enteric phytobezoars. Gastroscopy or gastroduodenoscopy revealed evidence 8 10 which these procedures performed. TREATMENT AND OUTCOME-2 13...

Medical humanities is a multidisciplinary, interdisciplinary field of study that has experienced explosive growth in the United States since 1960s. Two key components medical include, first, use literature, poetry, and visual arts education students, second, representation or examination culture by scholars humanities, arts, social sciences such as literary film creators, sociologists, anthropologists. The American Association Colleges recently reported 2018, approximately 94% schools had...

A 14-year-old spayed American Paint mare was evaluated for mild colic, anorexia, pyrexia, and pancytopenia. Physical examination revealed tachycardia, tachypnea, pale mucous membranes. Serial laboratory analyses progressive pancytopenia, hyperfibrinogenemia, hyperglobulinemia. few large atypical cells were observed in peripheral blood smears. Results of tests equine infectious anemia antipenicillin antibody negative. Serum protein electrophoresis indicated a polyclonal gammopathy. Smears...

Summary Interpretation of eosinophilia in body fluids or tissues is often not straightforward. Eosinophil counts vary among clinically healthy individuals, and considerable overlap can occur between normal affected animals conditions such as allergic airway disease. Parasite exposure a confounding factor when are increased, cases where very high dramatic clinical signs make another disease process obvious, the underlying pathology may be uncertain treatment difficult. Eosinophils component...

Performing euthanasia is likely one of the most challenging tasks a veterinarian faces. Four students at Tufts University School Veterinary Medicine felt that they and their classmates needed additional training on this subject. They informally surveyed to determine what topics formats desired. The findings were used develop Euthanasia Workshop university, voluntary series lectures discussions technical emotional issues relating euthanasia. four then 30 North American veterinary colleges...

A 5-month-old Pony of the Americas colt presented to Oklahoma State University's Boren Veterinary Medical Teaching Hospital with a history neurologic signs present since birth. The foal's condition had deteriorated point where rising from recumbency required owner's assistance. was born full term multiparous mare. dam's previous foals were normal, and none shared same sire as this colt. birth unattended, but known have occurred within 1-hour period time. foal found recumbent normal...

Background Research in humans has demonstrated that high serum iron (sFe) concentration can predispose to infection, and many infections subsequently result alterations of host sFe. A decrease sFe is an early sensitive indicator systemic inflammation caused by tissue necrosis, bacterial infections, or endotoxemia horses. Serum parameters acute equine herpesvirus type 1 ( EHV ‐1) infection have not been evaluated previously. Objectives To document the response ‐1 determine whether significant...

Summary A 20‐year‐old Quarter Horse mare was presented with a firm, nonpainful swelling near the axial margin of left mammary gland. Ultrasound examination mass revealed 35 mm poorly encapsulated, homogeneous within parenchyma Using histopathology and immunohistochemistry, diagnosed as carcinoma showed positivity for cytokeratin 18 ( CK 18), vimentin α‐smooth muscle actin. Additionally, mRNA expression level oncogene cM yc did not show significant upregulation, whereas p53 , well‐known...

Summary Eosinophils are becoming the target of increasing research interest as recent studies suggest that their role in immune homoeostasis and response to disease is far more complex than previously understood. Historically, horse eosinophil has been used study basic biology because considerable volume blood required obtain enough viable cells for reliable, repeatable experiments. This resulted a large but disseminated body literature pertaining structure function eosinophil. More...

Invasive trophoblast from Day 34 horse conceptuses survives in extrauterine sites allogeneic recipients that are immunologically naive to donor major histocompatibility complex class I antigens. The ectopic retains its utero characteristics, including similar lifespan, physiologic effect of secreted product (equine chorionic gonadotropin) upon the recipient's ovaries, and induction host immune responses. Immunologic memory has not been considered previously this experimental system. We...

Performing euthanasia is likely one of the most challenging tasks a veterinarian faces. Four students at Tufts University School Veterinary Medicine felt that they and their classmates needed additional training on this subject. They informally surveyed to determine what topics formats desired. The findings were used develop Euthanasia Workshop university, voluntary series lectures discussions technical emotional issues relating euthanasia. four then 30 North American veterinary colleges...

Suturing is widely regarded to be a core competency of veterinary education. With curricular requirements expanding, training interventions that improve students' suturing skills without added time would valuable. This study evaluated the effects stroboscopic visual resistance training, technique using intermittent occlusion vision, and guided visualization on speed. Students' anxiety levels were also assessed. Twenty-nine students with no prior surgical experience divided into stroboscopic,...