Dimethylsulfoxide (DMSO) is an aprotic solvent that has the ability to induce cell fusion and differentiation enhance permeability of lipid membranes. It also effective cryoprotectant. Insights into how this molecule modulates membrane structure function would be invaluable toward regulating above processes for developing chemical means enhancing or hindering absorption biologically active molecules, in particular via skin. We show here by molecular simulations DMSO can water pores...

Background— We evaluated the progression of metabolic syndrome (MetS) and its components, trajectories followed by individuals entering MetS, manner in which different predict cardiovascular disease mortality. Methods Results— Using data from 3078 participants Framingham Offspring Study (a cohort study) who attended examinations 4 (1987), 5 (1991), 6 (1995), we MetS components. was defined according to Adult Treatment Panel III criteria. logistic regression, predictive ability presence each...

The structure and growth of crystal nuclei that spontaneously form during computer simulations the simplest nontrivial model a liquid, hard sphere system, is described in this work. Compact are observed to at densities within coexistence region phase diagram. possess range morphologies with predominance multiply twinned particles possessing some cases significant decahedral character. However do not from an initial core but appear nucleate as blocks face-centered cubic partially bounded by...

An improved method for the modelling of carbon structures based on a hybrid reverse Monte Carlo (HRMC) is presented. This algorithm incorporates an accurate environment dependent interaction potential (EDIP) in conjunction with commonly used constraints derived from experimental data. In this work, we compare new other results small system 2.9 g/cc amorphous carbon. We find that approach greatly improves structural description, alleviating common problem standard (RMC) generating high...

The reverse Monte Carlo (RMC) method was utilized in order to obtain three-dimensional atom configurations glassy carbon using measurements of the static structure provided by electron diffraction. This allowed local and medium-range formed at heat-treatment temperatures 1000 2500 \ifmmode^\circ\else\textdegree\fi{}C be analyzed detail. In particular, nature graphitelike bonding within glassy-carbon investigated as well form disorder that gives rise particular features its factor. produced...

Individuals with elevated levels of plasma low density lipoprotein (LDL) cholesterol (LDL-C) are considered to be at risk developing coronary heart disease. LDL particles removed from the blood by a process known as receptor-mediated endocytosis, which occurs mainly in liver. A series classical experiments delineated major steps endocytotic process; apolipoprotein B-100 present on binds specific receptor (LDL receptor, LDL-R) specialized areas cell surface called clathrin-coated pits. The...

The large hepatitis delta antigen (HDAg-L) mediates virus (HDV) assembly and inhibits HDV RNA replication. Farnesylation of the cysteine residue within HDAg-L carboxyl terminus is required for both functions. Here, proteins from different genotypes genotype chimeric were analyzed their ability to incorporate into virus-like particles (VLPs). Observed differences in efficiency VLP incorporation could be attributed genotype-specific terminus. Using a novel assay quantify extent farnesylation,...

The structural origin of the commonly observed split second peak radial distribution function a supercooled or glassy liquid is examined in this work using hard-sphere fluid as an example. A novel approach to analysis microscopic structure described, which permits decomposition both and bond-angle system particles into contributions from small number ring structures. method uses modified shortest-path definition rings appropriate medium-range dense systems. It shown that indicator emergence...

In this study we use a new topological structure measure to analyze the local environment of 923 atom gold clusters quenched from melt, at various quench rates, by molecular dynamics. The crystallization and geometrical rearrangements core atoms upon freezing can be clearly observed using our which is based on planar graphs. Our results support hypothesis that initiated surface proceeds into cluster core.

The evolution of the microstructure and composition occurring in aqueous solutions di-alkyl chain cationic/nonionic surfactant mixtures has been studied detail using small angle neutron scattering, SANS. For all systems we observe an from a predominantly lamellar phase, for rich cationic surfactant, to mixed micelles, nonionic surfactant. At intermediate solution compositions there is region coexistence micellar phases, where relative amounts change with composition. A number different...

We present a methodology for modeling atomically layered nanoporous carbonaceous solids. Our method models carbon atoms interacting on sets of analytically defined surfaces, in conjunction with reverse Monte Carlo techniques (RMC). approach allows the construction large, physically realistic low-density solids that are both physical and statistically consistent experimental observations. To demonstrate flexibility our to investigate different mesostructures, we have modeled two structures...

Elevated levels of low-density-lipoprotein cholesterol (LDL-C) in the plasma are a well-established risk factor for development coronary heart disease. Plasma LDL-C part determined by rate at which LDL particles removed from bloodstream hepatic uptake. The uptake mammalian liver cells occurs mainly via receptor-mediated endocytosis, process entails binding these to specific receptors specialised areas cell surface, subsequent internalization receptor-lipoprotein complex, and ultimately...

ABSTRACT A novel hepatitis B virus surface antigen mutant harboring a deletion of most the major antigenic loop region was competent for self-assembly and secretion. Although protein interaction with incorporation free large delta antigen, it partially defective in RNP incorporation.

An abstract is not available for this content. As you have access to content, full HTML content provided on page. A PDF of also in through the ‘Save PDF’ action button.