A5040232485- Oxidative Organic Chemistry Reactions
- Computational Drug Discovery Methods
- Metal-Catalyzed Oxygenation Mechanisms
- Pharmacological Receptor Mechanisms and Effects
- Porphyrin and Phthalocyanine Chemistry
- Biochemical and biochemical processes
- Phytochemicals and Antioxidant Activities
- Crystallography and molecular interactions
- Synthesis and biological activity
- Protein Structure and Dynamics
- Food Chemistry and Fat Analysis
- Crystal structures of chemical compounds
- Fluorine in Organic Chemistry
- Alkaloids: synthesis and pharmacology
- Plant biochemistry and biosynthesis
Massachusetts Institute of Technology
2021-2025
Vassar College
2020-2021
Abstract Nitriles are uncommon in nature and typically constructed from oximes through the oxidative decarboxylation of amino acid substrates or derivatization carboxylic acids. Here we report a third nitrile biosynthesis strategy featuring cyanobacterial synthase AetD. During eagle-killing neurotoxin, aetokthonotoxin, AetD transforms 2-aminopropionate portion 5,7-dibromo- l -tryptophan to nitrile. Employing combination structural, biochemical biophysical techniques, characterized as...
The plasmanylethanolamine desaturase enzyme (EC 1.14.99.19) is an integral membrane protein responsible for the catalytic conversion of alkyl ether phosphatidylethanolamines (AEPEs) to vinyl phosphatidylethanolamine (VEPEs)1-3. VEPEs, collectively known as plasmalogens, are glycerophospholipids characterized by a bond at glycerol sn-1 position1,3. Localized in mammalian brain, heart, and white blood cells, well most subcellular membranes, these plasmalogens critical signaling factors against...
The novel coronavirus SARS-CoV-2 Main Protease (Mpro) is an internally encoded enzyme that hydrolyzes the translated polyproteins at designated sites. protease directly mediates viral replication processes; hence, a promising target for drug design. Plant-based natural products, especially polyphenols and phenolic compounds, provide scaffold many effective antiviral medications, have recently been shown to be able inhibit Mpro of SARS-CoV-2. Specifically, polyphenolic compounds found in...
Nitriles are uncommon in nature and typically constructed from oximes via the oxidative decarboxylation of amino acid substrates or derivatization carboxylic acids. Here we report a third strategy nitrile biosynthesis featuring cyanobacterial synthase AetD. During 'eagle-killing' neurotoxin, aetokthonotoxin, AetD converts alanyl side chain 5,7-dibromo-L-tryptophan to nitrile. Employing combination structural, biochemical, biophysical techniques, characterized as non-heme diiron enzyme that...
The title compound [systematic name: 5-(trifluoromethyl)pyridine-2-carboxylic acid monohydrate], C 7 H 4 F 3 NO 2 ·H O, is the hydrate of a pyridine with carboxylic group and trifluoromethyl substituent situated para to one another on aromatic ring. molecule forms centrosymmetric water-bridged hydrogen-bonding dimer graph-set notation R (12). Hydrogen-bonding distances 2.5219 (11) 2.8213 Å are observed between donor bridging water acceptor, carbonyl oxygen respectively. dimers further linked...