A5114910882- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Microbial Metabolism and Applications
- Microbial Metabolic Engineering and Bioproduction
- Probiotics and Fermented Foods
- Microbial Natural Products and Biosynthesis
University of Hong Kong
2025
The human microbiome produces diverse metabolites that influence host health, yet the chemical landscape of ribosomally synthesized and post-translationally modified peptides (RiPPs)-a versatile class bioactive compounds-remains underexplored. Here, we conduct a large-scale biosynthetic analysis 306,481 microbial genomes from human-associated microbiomes, uncovering broad array yet-to-be-discovered RiPPs. These RiPPs are distributed across various body sites but show specific enrichment in...
Abstract The human microbiome holds tremendous potential for generating specialized peptides, specifically ribosomally synthesized and post-translationally modified peptides (RiPPs), significantly affecting health by mediating interactions with other microbes the host. However, capacity of our to produce these their links are poorly understood. This study systematically analyzes 306,481 microbiota-associated genomes, uncovering a broad array yet-to-be-discovered RiPPs. These RiPPs...