A5039000922- X-ray Diffraction in Crystallography
- Monoclonal and Polyclonal Antibodies Research
- Crystallization and Solubility Studies
- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- RNA Research and Splicing
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Protein Structure and Dynamics
- Peptidase Inhibition and Analysis
- Peroxisome Proliferator-Activated Receptors
- Enzyme Structure and Function
- Signaling Pathways in Disease
- Cancer-related Molecular Pathways
Jagiellonian University
2019-2022
University of Groningen
2018-2020
Abstract Stapled peptides are chemical entities in‐between biologics and small molecules, which have proven to be the solution high affinity protein–protein interaction antagonism, while keeping control over pharmacological performance such as stability membrane penetration. We demonstrate that multicomponent reaction‐based stapling is an effective strategy for development of α‐helical with highly potent dual antagonistic action MDM2 MDMX binding p53. Such a inhibitory activity p53‐MDM2/X...
Development of small molecules targeting the PD-L1/PD-1 interface is advancing both in industry and academia, but only a few have reached early-stage clinical trials. Here, we take closer look at general druggability PD-L1 using silico hot spot mapping nuclear magnetic resonance (NMR)-based characterization. We found that conformational elasticity surface strongly influences formation spots. deconstructed several generations known inhibitors into fragments examined their binding properties...
Abstract Stapled peptides are chemical entities in‐between biologics and small molecules, which have proven to be the solution high affinity protein–protein interaction antagonism, while keeping control over pharmacological performance such as stability membrane penetration. We demonstrate that multicomponent reaction‐based stapling is an effective strategy for development of α‐helical with highly potent dual antagonistic action MDM2 MDMX binding p53. Such a inhibitory activity p53‐MDM2/X...
Peroxisomes are a major cellular compartment of eukaryotic cells, and involved in variety metabolic functions pathways according to species, cell type environmental conditions. Their biogenesis relies on conserved genes known as PEX that encode peroxin proteins. Peroxisomal membrane proteins peroxisomal matrix generated the cytosol subsequently imported into peroxisome post-translationally. Matrix containing targeting signal 1 (PTS1) recognized by cycling receptor Pex5p transported lumen....