A5072462291- Plant biochemistry and biosynthesis
- Cancer therapeutics and mechanisms
- Bioactive Compounds and Antitumor Agents
- Plant Gene Expression Analysis
- Synthesis and biological activity
- Nephrotoxicity and Medicinal Plants
- Traditional Chinese Medicine Analysis
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and bioactivity of alkaloids
- Ginger and Zingiberaceae research
- Plant Molecular Biology Research
- Photosynthetic Processes and Mechanisms
- Berberine and alkaloids research
- Microbial Natural Products and Biosynthesis
- Microbial Metabolism and Applications
- Click Chemistry and Applications
- Drug-Induced Hepatotoxicity and Protection
- Plant Stress Responses and Tolerance
- Natural product bioactivities and synthesis
Chinese Academy of Medical Sciences & Peking Union Medical College
2007-2025
State Administration of Traditional Chinese Medicine of the People's Republic of China
2023-2024
Ministry of Education of the People's Republic of China
2023-2024
Beijing Union University
2010
Abstract Salvia miltiorrhiza is well known for its clinical practice in treating heart and cardiovascular diseases. Its roots, used traditional Chinese medicine materials, are usually brick-red due to accumulation of red pigments, such as tanshinone IIA I. Here we report a S. line (shh) with orange roots. Compared the roots normal plants, contents tanshinones single bond at C-15,16 were increased, whereas those double significantly decreased shh. We assembled high-quality chromosome-level...
Aporphine alkaloids are a large group of natural compounds with extensive pharmaceutical application prospects. The biosynthesis aporphine has been paid attentions in the past decades. Here, we determined contents four 1-benzylisoquinoline and five root, stem, leaf, flower Aristolochia contorta Bunge, which belongs to magnoliids. Two CYP80 enzymes were identified characterized from A. contorta. Both them catalyze unusual C-C phenol coupling reactions directly form alkaloid skeleton....
SUMMARY Prunella vulgaris is one of the bestselling and widely used medicinal herbs. It recorded as an ace medicine for cleansing protecting liver in Chinese Pharmacopoeia has been main constitutions many herbal tea formulas China centuries. also a traditional folk Europe other countries Asia. Pentacyclic triterpenoids are major class bioactive compounds produced P. . However, their biosynthetic mechanism remains to be elucidated. Here, we report chromosome‐level reference genome using...
Abstract Aristolochic acids (AAs) and their derivatives are present in multiple Aristolochiaceae species that have been or being used as medicinal materials. During the past decades, AAs received increasing attention because of nephrotoxicity carcinogenicity. Elimination from materials using biotechnological approaches is important for improving medication safety. However, it has not achieved limited information available on AA biosynthesis. Here, we report a high-quality, reference-grade...