A5073272684- Antibiotics Pharmacokinetics and Efficacy
- Ocular Infections and Treatments
- Retinal Diseases and Treatments
- Retinal and Macular Surgery
- Antifungal resistance and susceptibility
- Pharmaceutical Practices and Patient Outcomes
- Pharmacogenetics and Drug Metabolism
- Analytical Methods in Pharmaceuticals
- Biomedical Research and Pathophysiology
- Pharmaceutical studies and practices
- Schizophrenia research and treatment
- Amino Acid Enzymes and Metabolism
- Inflammatory Bowel Disease
- Antimicrobial Resistance in Staphylococcus
- Drug Transport and Resistance Mechanisms
- Sexual function and dysfunction studies
- Neonatal Health and Biochemistry
- Genital Health and Disease
- Medication Adherence and Compliance
- Health Systems, Economic Evaluations, Quality of Life
- Biosimilars and Bioanalytical Methods
- Lymphoma Diagnosis and Treatment
- Pharmacy and Medical Practices
- Ocular Surface and Contact Lens
- Ethics and bioethics in healthcare
Servicio Gallego de Salud
2019-2025
Instituto de Investigación Sanitaria de Santiago
2019-2025
Universidade de Santiago de Compostela
2019-2025
Complejo Hospitalario Universitario de Santiago
2013-2024
National University of Jujuy
2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2024
Complexo Hospitalario Universitario A Coruña
2013-2024
Fundación Pública Galega de Medicina Xenómica
2017-2020
University of Florence
2009
Most of our knowledge on divorce pertains to the USA and northern Europe, while demographic studies from southern Europe are relatively scarce. Our study looks at this gap through an analysis correlates marital instability in Italy.
Aripiprazole (ARI) is an atypical antipsychotic which a substrate of P-glycoprotein (P-gp), transmembrane glycoprotein that plays crucial role in eliminating potentially harmful compounds from the organism. ARI once-monthly (AOM) long-acting injectable form improves treatment compliance. Genetic polymorphisms ABCB1 may lead to changes P-gp function, leading individual differences drug disposition. The present study aims determine how different variants three most prevalent SNPs gene affect...
Abstract (315 /350) Objectives: To describe the relationship between individual workers employed at more than one LTCH (inter-LTCH connectivity) across long-term care homes (LTCH) and SARS-CoV-2 outbreaks. Design: A retrospective cohort study using home surveillance mobile geolocation data. Setting: Using data observed February 26th, 2020, August 31st, from Ontario, province where close to one-third of Canada′s cases among residents were reported. Participants: We included all 179 in Greater...
Therapeutic drug monitoring improves the benefit-risk balance of antipsychotic therapy. Ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) is considered gold-standard method for measuring plasma concentrations; however, Alinity C system has emerged as a promising alternative. This first study aimed at comparing UHPLC-MS/MS versus in concentrations aripiprazole and dehydroaripiprazole. A total 86 samples were analyzed. The active moiety was measured 60 using...
Voriconazole is an antifungal metabolised by CYP2C19 enzyme, which can be inhibited proton‐pump inhibitors (PPIs). A prospective observational study was carried out to determine the influence of PPIs on voriconazole pharmacokinetic. The 78 patients included were divided into 4 groups: omeprazole ( n = 32), pantoprazole 25), esomeprazole 3) and no PPI 18). Patients with had significant difference in plasma concentration when compared those (2.63 ± 2.13 μg/mL [95% confidence interval {CI}...
Background Voriconazole, a first‐line agent for the treatment of invasive fungal infections, is mainly metabolized by cytochrome P450 (CYP) 2C19. A significant portion patients fail to achieve therapeutic voriconazole trough concentrations, with consequently increased risk failure. Objective To show association between subtherapeutic concentrations and factors affecting pharmacokinetics: CYP2C19 genotype drug–drug interactions. Methods Adults receiving antifungal or prophylaxis were included...
The cognitive safety of monoclonal antibody proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) has been established in clinical trials, but not yet real-world observational studies. We assessed the function patients initiating PCSK9i, and differences domains, to analyze subgroups by low-density lipoprotein cholesterol (LDL-C) achieved, between alirocumab evolocumab.This a multicenter, quasi-experimental design carried out 12 Spanish hospitals from May 2020 February 2023....
The introduction of point-of-care (POC) assays into clinical practice in patients with inflammatory disease enables on-demand therapeutic decision making. aim this study was to compare the POC test Quantum blue (Bühlmann Laboratories) for infliximab (IFX), adalimumab (ADL), and its anti-drug antibodies traditional ELISA assay (Promonitor). A total 200 serum samples were analyzed. Samples classified following three different groups; sub-therapeutic range (IFX < 3 μg/mL ADL 5 μg/mL); (IFX: 3-7...
Inhaled administration of ethanol in the early stages COVID-19 would favor its location on initial replication sites, being able to reduce progression disease and improving prognosis. Before evaluating efficacy safety this novel therapeutic strategy humans, characterization is required. The developed 65° formulation stable at room temperature protected from light for 15 days, maintaining physicochemical microbiological properties. Two oxygen flows have been tested (2 3 L/min) using an...
Cystinosis is a rare genetic disorder characterized by the accumulation of cystine crystals in different tissues and organs causing, among other symptoms, severe ocular manifestations. Cysteamine eye drops are prepared hospital pharmacy departments to facilitate access treatment, for which vehicles that provide adequate biopermanence, as well adaptable containers maintain its stability, required. Difficulties related cysteamine preparation, tendency oxidize cystamine, show importance...
Cystinosis is a rare genetic disorder characterized by the accumulation of cystine crystals in several tissues and organs causing, among others, severe eye symptoms. The high instability cysteamine drops makes it difficult to develop formulations with an acceptable shelf life be prepared hospital pharmacy departments. Previously, new compounded formulation hyaluronic acid (HA) packaged innovative single-dose systems was developed.Long-term stability at -20 °C this studied considering content...
Separazione e divorzio in Italia. Le tendenze le differenze regionali La diffusione di separazioni divorzi Italia puo portare a conseguenze individuali sociali rilevanti, poiche cambiare il ruolo della famiglia all’interno societa, la posizione donna nei confronti dell’attivita professionale, scelte maternita paternita. L’interpretazione questi mutamenti non prescindere da una ricostruzione delle dello scioglimento dei matrimoni livello territoriale disaggregato, come ci accingiamo fare...