Soil as the basis of ecotope largely determines macro-and microelement composition plants growing on it. The predominant soils in steppe zone Southern Urals are chernozems, among which leached, ordinary and southern subtypes widespread. Migration elements “soil - plant” system is determined by type soil, properties, nature parent rocks, well specificity plant species other factors. Studying influence geochemical features ecological state purity raw materials medicinal an urgent problem....

In this study the ability of spherical particles (SPs) obtained from tobacco mosaic virus (TMV) virions to enhance immunogenic potential vaccine was evaluated. TMV SPs were shown increase protective properties widely used effective Russian adjuvant-free rabies vaccine, composed killed virions. The results NIH potency test showed enhancement protectivity, that is comparable with effect incomplete Freund׳s adjuvant on same vaccine.

The comprehensive approach to solving the issue of animal raising intensification, integrated part which is herd breeding, yield preservation and its development provision, conditioned enhancement research works aimed at further investigation young stock diseases, features their digestion development, search efficient preventive treatment measures, feeds feed additives for simulating growth development. main objective this study was exploration comparative therapeutic efficiency use in...

The core element of the reindeer rabies eradication strategy is regular application vaccines to obtain and uphold a vaccination coverage sufficient for ceasing virus transmission. This article presents results humoral immunity intensity duration study after immunization with two form inactivated (adjuvanted liquid vaccine non-adjuvanted lyophilized vaccine) based on Shchelkovo-51 strain. Efficiency post-vaccine was assessed by measuring animal blood serum virus-neutralizing antibody level in...

Reproductive disorders, presumably caused by Chlamydia abortus, are common among the ovine population of Mari El Republic, Russia. C. abortus infection was determined serologic testing or isolation and detection organism PCR direct immunofluorescence in tissue samples. Rams, ewes, lambs (10 individuals each) were randomly chosen for serological complement fixation test 7 30 (23%) animals tested positive. Tissue samples collected from ewes aborted fetuses inoculating chicken embryo yolk sacs...

Chlamydia abortus is the etiological agent of abortion and fetal loss in sheep, goats bovine cattle many countries. Even though commercially available vaccines can reduce incidence development new, safe, effective remains high on agenda. In this study, an evaluation was made efficacy a vaccine candidate, inactivated antigen based extract outer membrane proteins C. strain known as VNITIBP-21, combination with recombinant flagellin adjuvant. Pregnant sheep (n = 43) were divided into three...

Thermal spring water is currently widely used as a finished product in the form of spray and an important component effective dermatological cosmetic products. In Russian Federation, nitrogensilicon thermal waters (ASTW) are widespread Far East, especially Kamchatka, which means they significantly removed from enterprises mainland Russia that produce The high cost delivery to processing sites leads higher prices for drugs containing component. purpose research was concentrate certain...

Despite the huge achievements of pharmaceutical chemistry, herbal medicines based on medicinal plant raw materials (MPRMs) are still in demand for treatment both humans and animals diseases. Their main advantage is small number contraindications side effects. In this case, not one but several phytocompositions often used, which makes it possible to enhance effectiveness drugs expand spectrum action. The key point creating multicomponent (galenic) preparations development an accurate...

Rabies is a zoonotic disease with high degree of lethality. Most human deaths are related to bites received from dogs and cats. Vaccination the most effective method preventing rabies in both animals humans. In this study, ability an adjuvant based on recombinant Salmonella typhimurium flagellin increase protective activity inactivated vaccine mice was evaluated. A series dry culture for cats “Rabikan” (strain “Shchelkovo-51”) addition various dilutions were used. The control preparation...

The possibility of practical use perfusion cell culture technology VNK-21/13-13 was evaluated in the manufacture rabies vaccine using bioreactors with a working volume 5 liters and 100 liters. purpose this study is to develop highly effective for continuous suspension cultivation transplanted BHK– 21/13-13 line, suitable as cellular substrate vaccine. Using Cytiva filter elements made PES membrane material retention rating 0.65 microns, density above 7× 106 cells/ml achieved subsequent...

Chlamydia is a separate group of bacteria adapted to intracellular parasitism, characterized by distribution among wide range hosts and variety clinical manifestations. abortus promotes colonization placental trophoblasts one the causes abortions fetal loss in sheep, goats cattle. Experimental studies have shown high immunogenic activity C. VNITIBP-21 strain (protective activity-98.5-99.5%), which makes it possible consider as candidate for design effective means preventing chlamydia...

Polymerase chain reaction (PCR) is one of the most common methods in molecular biology. Since each unique, optimal conditions for obtaining product may vary. Understanding variables that influence response can significantly improve efficiency process and ensure desired result achieved.

Presents the results of research studies in field technology development industrial production biological products. Shows improving biotechnological processes upon receipt veterinary drugs.

The article discusses the main provisions and principles of 3R concept, which regulates approaches to working with laboratory animals. concept itself consists 3 areas: Replacement animals in experiment other models, reduction use animal objects by optimizing experimental conditions improvement existing methods aimed at reducing pain stress during experiments. A number are subject criticism. Different stakeholders (for example, experimenters, representatives institutions, politi-cians,...

The creative path in science of Ivanov Viktor Serafimovich, and his achievements are presented. His developments virology for veterinary medicine shown.

Nowadays, chitosan-based biostimulants and their derivatives are being increasingly utilized in veterinary medicine. These substances possess numerous advantageous properties that make them suitable for application beekeeping. Chitosan its modified forms of natural origin non-toxic, exhibiting immunomodulating antimicrobial activity. They also have the ability to enhance resistance eliminate heavy metals toxins from bees' bodies. is derived chitin, a component found exoskeleton bees. When...

Method of electrical stimulation cells on bioengineering nanocomposite substrates with pulses amplitude from 60 mV to 120 and pulse duration 2.5 ms for 24 h is developed. Nanocomposite consist a polymer matrix based natural components - protein albumin, aminosugar chitosan reinforcing filler carbon nanotubes have three-dimensional structure an internal electrically conductive frame created by laser formation. A developed device allows the transmission stimulating signals through conducting...

The objective of this study was the analysis adaptogenic effects chitosan at gamma-irradiation. radioprotective properties carried out on male mice having weight 20-25 g, exposed to gamma-irradiation doses up 800 bar Gamma Panorama unit (radiation source – Cs137, gamma dose rate 14 R/min, duration irradiation 58.5 min). 4 experimental and 2 control groups with 7 animals in each have been formed. medicine schedule, allowing identify both prophylactic effect therapeutic chitosan, used...