A5085586337- Epigenetics and DNA Methylation
- Birth, Development, and Health
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Dietary Effects on Health
- Folate and B Vitamins Research
- Circadian rhythm and melatonin
- Diet and metabolism studies
- RNA modifications and cancer
- Fatty Acid Research and Health
- Extracellular vesicles in disease
- Circular RNAs in diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Diet, Metabolism, and Disease
- Cardiovascular Disease and Adiposity
- Pancreatic function and diabetes
- Gut microbiota and health
- Child Nutrition and Water Access
- Clostridium difficile and Clostridium perfringens research
- Barrier Structure and Function Studies
- GDF15 and Related Biomarkers
Universidad de Navarra
2015-2024
Instituto de Salud Carlos III
2018
Centro de Investigación Biomédica en Red
2018
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2015
Universidade Federal de Viçosa
2015
Navarre Institute of Health Research
2015
Aging entails changes at the cellular level that increase risk of various pathologies. An association between gut microbiota and age-related diseases has also been attributed. This study aims to analyze in fecal composition their with genes related immune response, inflammation, intestinal barrier impairment. Fecal samples female mice different ages (2 months, 6 12 18 months) gene expression colon tissue were analyzed. Results showed older group had a more diverse than younger group....
DNA methylation has been suggested as a regulatory mechanism behind some inflammatory processes. The physiological actions of methyl donors, such folic acid, choline, and vitamin B12 on inflammation-related disease have associated with the synthesis universal donor S-adenosyl methionine (SAM). aim this study was to evaluate effects B12, combination all preventing lipopolysaccharide- (LPS-) induced response in human THP-1 monocyte/macrophage cells. Folic acid mixture donors reduced...
The circadian clock regulates the daily rhythms of several physiological and behavioral processes. Disruptions in genes have been associated with obesity related comorbidities. This study aimed to analyze association DNA methylation signatures at rhythm pathway body mass index (BMI), metabolic profiles dietary intakes. profiling was determined by microarray white blood cells from 474 adults Methyl Epigenome Network Association (MENA) project. Kyoto Encyclopedia Genes Genomes database used...
Summary Background The global prevalence of childhood overweight and obesity has increased in the last years. Epigenetic dysregulation affecting gene expression could be a determinant early‐life onset accompanying complications. Objective aim present investigation was to analyse putative association between DNA methylation obesity. Methods isolated from white blood cells 24 children obtained GENOI study hybridized 450K array. Two CpG sites associated with were validated 91 by MassArray®...
The circadian clock system has been linked to the onset and development of obesity some accompanying comorbidities. Epigenetic mechanisms, such as DNA methylation, are putatively involved in regulation system. aim this study was investigate influence a weight loss intervention based on an energy-controlled Mediterranean dietary pattern methylation levels 3 genes, BMAL1, CLOCK, NR1D1, association between changes induced serum lipid profile with treatment. sample enrolled 61 women (body mass...