In repair of truncus arteriosus the accepted methods establishing right ventricle (RV) to pulmonary artery (PA) continuity utilize an allograft or xenograft valved conduit. Alternatively, PA confluence may be directly anastomosed RV with anterior patch augmentation, which allow growth and delay avoid subsequent RVOT obstruction. These reconstruction were evaluated in infants undergoing repair.A retrospective analysis 61 between November 1988 June 2000 was performed. Median age 34 days (range...

Summary In a randomised trial, we compared the effects of oral sildenafil (0.5 mg.kg −1 ) and placebo, administered day before cardiac surgery, in 24 children. vs placebo patients, pre‐cardiopulmonary bypass median (IQR [range]) cyclic‐guanosine‐monophosphate was not significantly different (29.9 (2.1–208.1 [0.5–391.5]) 5.2 (0.3–54.6 [0–628.9]) pmol.ml , respectively). Post‐cardiopulmonary bypass, nitrate/nitrite levels were also (0.7 (0–8.0 [0–142.8]) 0 (0–2.7 [0–52.7]) μM, Postoperatively,...

Abstract Dysfunction of mitral valve causes morbidity and premature mortality remains a leading medical problem worldwide. Computational modelling aims to understand the biomechanics human could lead development new treatment, prevention diagnosis diseases. Compared with aortic valve, has been much less studied owing its highly complex structure strong interaction blood flow ventricles. However, interest in is growing, sophistication level increasing advanced computational technology imaging...

<title>Abstract</title> Digital twins of cardiac function are revolutionizing the management heart diseases. Pulmonary valve regurgitation (PR), a common complication following repair tetralogy Fallot, can lead to detrimental effects on right ventricular (RV) if it persists. Although pulmonary replacement address PR, its long-term remain topic debate. Despite importance RV in overall function, high-fidelity in-silico models ventricle under-explored. In this study, we present novel...

Continuous ventricular volume measurement by the conductance method assumes a homogeneous electrical field dispersed throughout and contained within ventricle. Because of dense trabeculation complex geometry, right (RV) description this may be seriously compromised. This study sought to determine accuracy limitations RV conductance, with magnetic resonance (MR) imaging (MRI) used as reference, in porcine RV. Anesthetized pigs ( n = 5, 45–55 kg) were placed 1.5-T magnet, ECG-gated transverse...

Objective Myocardial fibrosis has been associated with poorer outcomes in tetralogy of Fallot, however only a handful studies have assessed its significance the current era. Our aim was to quantify amount late gadolinium enhancement both LV and RV contemporary cohort adults surgically repaired assess relationship adverse clinical outcomes. Design Single centre study Setting National tertiary referral center Patients: One hundred fourteen patients Fallot median age 29.5 years (range...

BACKGROUND: Prophylactic digoxin is widely used in patients undergoing pulmonary surgery to prevent or control cardiac arrhythmias, but whether it helpful not uncertain. METHODS: An open, controlled randomised prospective clinical study of 111 was undertaken compare the incidence arrhythmias 58 who received preoperative and 53 did not. RESULTS: Cardiac arrhythmia occurred half (29/58) those given prophylactic 36% (19/53) were The overall 43%, with no statistically significant difference...

In this study, tissue Doppler imaging (TDI) was used to assess changes in ventricular function following repair of congenital heart defects. The relationship between TDI indices, myocardial injury and clinical outcome explored. Forty-five children were studied; 35 with cardiac lesions 10 controls. performed preoperatively, on admission paediatric intensive care unit (PICU) day 1. Regional signals acquired from the right ventricle (RV), left (LV) septum. indices included: peak systolic...

Abstract This paper aims to investigate detailed mechanical interactions between the pulmonary haemodynamics and left heart function in pathophysiological situations (e.g. atrial fibrillation acute mitral regurgitation). is achieved by developing a complex computational framework for coupled circulation, atrium valve model. The are modelled with physiologically realistic three-dimensional geometries, fibre-reinforced hyperelastic materials fluid–structure interaction, vessels as...

The ability of the right ventricle to tolerate acute pulmonary regurgitation (PR) following tetralogy Fallot (TOF) repair is variable and mechanisms that underlie this are not completely understood. We hypothesise dyssynchronous wall mechanics affects RV tolerance postoperative PR with adverse effect on early surgical outcome.Twenty-four TOFs (mean age 19.5+/-15.5 months) undergoing elective were prospectively recruited. Ventricular was studied by tissue Doppler echocardiography induction...

The aim of this study was to assess outcomes infants and children undergoing aortopexy try establish which would derive the greatest benefit from complex intervention. Materials andThis is a retrospective case series in pediatric tertiary referral hospital between 1993 2012. A sheet review performed collect demographic data identify for each child. effects subtype tracheomalacia, weight at surgery, symptoms presentation, surgical approach, preoperative ventilation were considered.There 30...

B-type natriuretic peptide (BNP) response early after a tetralogy of Fallot's repair remains unclear. BNP was measured pre- and post-operatively (immediately, day 1) in 18 children undergoing corrective with concurrent echocardiography (pre-, post-op to assess right ventricular (RV) systolic dysfunction, restrictive physiology, wall motion pulmonary regurgitation (PR). In the first 24 h postoperatively, rose acutely all patients (mean 34.9 vs 144.4 716.9 pg/ml at pre-op, days 0 1; P <...

We undertook a study to describe changes in heart rate variability (HRV) postoperatively children undergoing cardiac bypass surgery for congenital disease (CHD). HRV was recorded 1-h period preoperatively and 24-h 20 with CHD. found highly significant reduction both time frequency domain indices compared preoperative values, which sustained throughout the period. There negative correlation between measurements length of bypass. is reduced correlates time. Length may be one mechanism whereby...