A5038399091- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Neural Networks and Applications
- Neurological disorders and treatments
- Immune Response and Inflammation
- Receptor Mechanisms and Signaling
- Voice and Speech Disorders
- S100 Proteins and Annexins
- Transport and Logistics Innovations
- Optical Imaging and Spectroscopy Techniques
- Neuroscience and Neuropharmacology Research
- Lipid Membrane Structure and Behavior
- Advanced biosensing and bioanalysis techniques
- Advanced Fluorescence Microscopy Techniques
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
Radboud University Nijmegen
2020-2021
CIC biomaGUNE
2012-2016
Abstract CD163 is a membrane receptor expressed by macrophage lineage. Studies performed in atherosclerosis have shown that expression increased at inflammatory sites, pointing the presence of intraplaque hemorrhagic sites or asymptomatic plaques. Hence, imaging expressing macrophages an interesting strategy order to detect atherosclerotic We prepared targeted probe based on gold-coated iron oxide nanoparticles vectorized with anti-CD163 antibody for specific detection MRI. Firstly,...
The specificity of gradient echo (GE)-BOLD laminar fMRI activation profiles is degraded by intracortical veins that drain blood from lower to upper cortical layers, propagating signal in the same direction. This work describes an approach obtain layer specific deconvolving measured with a physiological Point Spread Function (PSF). It shown PSF can be characterised TE-dependent peak tail (p2t) value independent depth and estimated simulation. An experimental estimation individual p2t values...
The influence of toll-like receptor 4 on neurogenesis and inflammation has been scarcely explored so far by using neuroimaging techniques. For this purpose, we performed magnetic resonance imaging positron emission tomography with 3′-deoxy-3′-[ 18 F]fluorothymidine [ 11 C]PK11195 at 2, 7, 14 days following cerebral ischemia in TLR4 +/+ −/− mice. MRI showed similar infarction volumes both groups. Despite this, evidenced an increase a decrease mice after ischemia. These results evidence the...
Abstract Layer specific functional MRI requires high spatial resolution data. To compensate the associated poor signal to noise ratio it is common integrate from voxels at a given cortical depth. If region sufficiently large then physiological will be dominant source. In this work, activation profiles in response same visual stimulus are compared 1.5 T, 3 T and 7 using multi-echo, gradient echo (GE) FLASH sequence, with 0.75 mm isotropic voxel size integration approach. The results show that...
The precise biologic mechanisms involved in functional recovery processes response to stroke such as dopaminergic neurotransmission are still largely unknown. For this purpose, we performed parallel vivo magnetic resonance imaging and positron emission tomography (PET) with [ 18 F]fluorodeoxyglucose ([ F]FDG) 11 C]raclopride at 1, 3, 7, 14, 21, 28 days after middle cerebral artery occlusion rats. In the ischemic territory, PET F]FDG showed a initial decrease metabolism followed by...
Abstract Background The specificity of gradient echo (GE)-BOLD laminar fMRI activation profiles is degraded by intracortical veins that drain blood from lower to upper cortical layers, propagating signal in the same direction. This work describes an approach obtain layer specific deconvolving measured with a physiological Point Spread Function (PSF). New Method It shown PSF can be characterised TE-dependent peak tail (p2t) value independent depth and estimated simulation. An experimental...
Abstract Layer specific functional MRI requires high spatial resolution data. An approach often used for compensating the poor signal to noise ratio (SNR) associated with small voxel sizes consists of integrating from voxels at a given cortical depth over patch cortex. After this integration, physiological is expected be dominant source in signal. In context, sensitivity gain moving higher static field strengths lower than when thermal dominates. work, activation profiles response same...
Manufacturing is a significant component of Europe's economy and facing environmental as well globalisation challenges. Furthermore, manufacturing severely hit by the current economic downturn. In late 2008, European Commission launched Factories Future (FoF) initiative, part Economic Recovery Plan, with aim to boost industrial activity help overcome crisis strengthened more competitive. The R&D relevant FoF, supported two 7th Framework Programme themes, Nanosciences, Nanotechnologies,...
Oihartzun denbora eta eremu magnetiko estatikoaren araberako BOLD erantzunaren neurketa bereizmen handiko irudi bidezko erresonantzia magnetikoa erabiliz: In-vivo azterketa bat produkzioaren informazio-fitxa