A5076418988- Nanoparticle-Based Drug Delivery
- Neuroscience and Neuropharmacology Research
- Material Dynamics and Properties
- Polymer Nanocomposites and Properties
- Characterization and Applications of Magnetic Nanoparticles
- Nanoplatforms for cancer theranostics
- Receptor Mechanisms and Signaling
- Vagus Nerve Stimulation Research
- Advanced MRI Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- MRI in cancer diagnosis
- Nicotinic Acetylcholine Receptors Study
- Genetic and Kidney Cyst Diseases
- RNA Interference and Gene Delivery
- Adenosine and Purinergic Signaling
- Neuroscience of respiration and sleep
- Polymer crystallization and properties
- Micro and Nano Robotics
- Glioma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Advanced Nanomaterials in Catalysis
- Advanced Biosensing Techniques and Applications
- Iron Metabolism and Disorders
- Intracranial Aneurysms: Treatment and Complications
CIC biomaGUNE
2014-2025
Boeing (Spain)
2025
Digital Research Alliance of Canada
2025
Ayuntamiento de San Sebastián
2018
Material Physics Center
2009-2011
Donostia International Physics Center
2009-2011
University of the Basque Country
2010
Abstract Bladder cancer treatment via intravesical drug administration achieves reasonable survival rates but suffers from low therapeutic efficacy. To address the latter, self-propelled nanoparticles or nanobots have been proposed, taking advantage of their enhanced diffusion and mixing capabilities in urine when compared with conventional drugs passive nanoparticles. However, translational treating bladder are underexplored. Here, we tested radiolabelled mesoporous silica-based...
Abstract CD163 is a membrane receptor expressed by macrophage lineage. Studies performed in atherosclerosis have shown that expression increased at inflammatory sites, pointing the presence of intraplaque hemorrhagic sites or asymptomatic plaques. Hence, imaging expressing macrophages an interesting strategy order to detect atherosclerotic We prepared targeted probe based on gold-coated iron oxide nanoparticles vectorized with anti-CD163 antibody for specific detection MRI. Firstly,...
PEG coated magnetic nanocarriers avoid the reticuloendothelial system, and show an MRI contrast in kidneys. The results are supported by SPECT, gamma-counting, TEM histology.
Abstract Manganese ferrite nanoparticles display interesting features in bioimaging and catalytic therapies. They have been recently used theranostics as contrast agents magnetic resonance imaging (MRI), catalase‐mimicking nanozymes for hypoxia alleviation. These promising applications encourage the development of novel synthetic procedures to enhance properties these nanomaterials simultaneously. Herein, a cost‐efficient microwave method is developed manufacture ultrasmall manganese...
Abstract Background Identifying the precise location of cells and their migration dynamics is utmost importance for achieving therapeutic potential after implantation into a host. Magnetic resonance imaging suitable, non-invasive technique cell monitoring when used in combination with contrast agents. Results This work shows that nanowires an iron core oxide shell are excellent materials this application, due to customizable magnetic properties biocompatibility. The longitudinal transverse...
Atherosclerosis is a complex disease that can lead to life-threatening events, such as myocardial infarction and ischemic stroke. Despite the severity of this disease, diagnosing plaque vulnerability remains challenging due lack effective diagnostic tools. Conventional protocols specificity fail predict type atherosclerotic lesion risk rupture. To address issue, technologies are emerging, noninvasive medical imaging with customized nanotechnological solutions. Modulating biological...
The success of nanoparticle‐based therapies will depend in part on accurate delivery to target receptors and organs. There is, therefore, considerable potential nanoparticles which achieve the right drug(s) using route administration location at time, monitoring process by non‐invasive molecular imaging. A challenge is harnessing immunotherapy via activation Toll‐like (TLRs) for development vaccines against major infectious diseases cancer. In immunotherapy, vaccine components lymph nodes...
A new nanoparticle system with multimodal imaging features functionalized immunostimulatory dsRNA (poly (I:C)) is reported by J. C. Mareque-Rivas and co-workers. As described on page 5054, the nanocarrier capable of reaching endosomal TLR3 in cells immune system, significantly enhancing capacity poly (I:C) to trigger induction cytokines essential for activating system. MRI SPECT are combined elucidate its delivery lymph nodes – command centres
ABSTRACT Background Multiple sclerosis (MS) is a chronic demyelinating disease characterized by autoimmune attacks on myelin sheaths. Its deleterious effects may be reversed remyelination, process that restores the integrity of sheaths and, consequently, neuronal function. However, functional implications demyelination and remyelination in MS, as well potential impact therapeutic interventions, remain incompletely understood. We used noninvasive longitudinal resting‐state magnetic resonance...
Magnetic nanoparticles, especially iron oxide have become versatile and widely used tools in nanomedicine due to their unique magnetic properties, biocompatibility, tunable functionality. Liposomes further enhanced the potential of nanoparticles by serving as effective nanocarriers with advantages such drug coencapsulation molecular imaging properties. In this study, we present magnetoliposomes composed ultrasmall free-floating inside liposomes (LP-IONPs) thermoresponsive phospholipids,...
Abstract In vivo positron emission tomography (PET) imaging of nicotinic acetylcholine receptors (nAChRs) is a promising tool for the evaluation neurologic and neurodegenerative diseases. However, role α7 nAChRs after brain diseases such as cerebral ischemia its involvement in inflammatory reaction still largely unknown. ex expression transient middle artery occlusion (MCAO) was carried out using PET with [ 11 C]NS14492 immunohistochemistry (IHC). Pharmacological activation evaluated...
Nicotinic acetylcholine α7 receptors (α7 nAChRs) have a well-known modulator effect in neuroinflammation. Yet, the therapeutical of nAChRs activation after stroke has been scarcely evaluated to date. The role with PHA 568487 on inflammation brain ischemia was assessed positron emission tomography (PET) using [ 18 F]DPA-714 and F]BR-351 radiotracers transient middle cerebral artery occlusion (MCAO) rats. assessment oedema, blood barrier (BBB) disruption neurofunctional progression treatment T...
A novel strategy is described to study polymer dynamics by using a combination of dielectric spectroscopy and functionalized polymers. The first results are presented various well-defined, chain-end-functionalized polystyrenes (PS) synthesized modern anionic polymerization techniques hydrosilylation chemistry. end-functionalized investigated contain the cyano (−CN), hydroxyl (−OH), acetyl (−OCOCH3, −Ac), or ethyl ether (−OCH2CH3, −OEt) groups. By applying broadband (BDS) over an extensive...
In vivo positron-emission tomography (PET) imaging of transporter protein (TSPO) expression is an attractive and indispensable tool for the diagnosis therapy evaluation neuroinflammation after cerebral ischemia. Despite several radiotracers have shown excellent capacity to image neuroinflammation, novel such as [18F] VUIIS1008 promising properties visualize quantify in TSPO.Longitudinal magnetic resonance (MRI) PET studies with TSPO radiotracer 2-(5,7-diethyl-2-(4-(2-[18F] fluoroethoxy)...
Adenosine A1 receptors (A1ARs) are promising imaging biomarkers and targets for the treatment of stroke. Nevertheless, role A1ARs on ischemic damage its subsequent neuroinflammatory response has been scarcely explored so far. Methods: In this study, expression after transient middle cerebral artery occlusion (MCAO) was evaluated by positron emission tomography (PET) with [18F]CPFPX immunohistochemistry (IHC). addition, stroke inflammation using pharmacological modulation assessed magnetic...
Differences in the cerebro-vasculature among strains as well individual animals might explain variability animal models and thus, a non-invasive method tailored to image cerebral vessel of interest with high signal noise ratio is required.Experimentally, we describe new general protocol three-dimensional time-of-flight magnetic resonance angiography visualize non-invasively vasculature 6 different rat strains. Flow compensated angiograms Sprague Dawley, Wistar Kyoto, Lister Hooded, Long...
Medical imaging is an active field of research that fosters the necessity for novel multimodal probes. In this line, nanoparticle-based contrast agents are special interest, since those can host functional entities either within their interior, reducing potential toxic effects tracers, or on surface, providing high payloads probes, due to large surface-to-volume ratio. The long-term stability particles in solution aspect usually under-tackled during probe design laboratories, performance...
In vivo positron emission tomography of neuroinflammation has mainly focused on the evaluation glial cell activation using radiolabeled ligands. However, non-invasive imaging neuroinflammatory proliferation been scarcely evaluated so far. and ex assessment gliogenesis after transient middle cerebral artery occlusion (MCAO) in rats was carried out PET with marker 3'-Deoxy-3'-[18F] fluorothymidine ([18F]FLT), magnetic resonance (MRI) fluorescence immunohistochemistry. MRI-T2W studies showed...
Crossed cerebellar diaschisis (CCD) is a decrease of regional blood flow and metabolism in the hemisphere contralateral to injured brain as common consequence stroke. Despite CCD has been detected patients with stroke using neuroimaging modalities, evaluation this phenomenon rodent models cerebral ischemia scarcely evaluated so far. Here, we report vivo after long-term rats positron emission tomography (PET) imaging 2-deoxy-2-[ 18 F]fluoro-D-glucose ([ F]FDG). Imaging studies were combined...
The site-dependent segmental dynamics of polystyrene has been investigated by using a combination broadband dielectric spectroscopy (BDS) and well-defined, functionalized polystyrenes (Mn ≈ 2200 4200 g/mol) with strongly polar cyano (CN) groups precisely located either at the end chain (chain-end functionalization) or in middle (in-chain functionalization). Since is sensitive to local dipole moment fluctuations, it possible selectively probe polymer motions responsible for fluctuations these...
Background Efforts are continuously made to detect and investigate the pivotal processes interplay between response of sentinel lymph node malignant cells from a primary tumor. Conversely, some frequently used tumor animal models, such as human cancer xenografts, rarely feature metastasis. Therefore, alterations seldom assessed. We consider that studying could contribute understanding host reaction cancer. In present study, we explored presence regional in parallel with growth using...