A5038997858- Nanoparticle-Based Drug Delivery
- Characterization and Applications of Magnetic Nanoparticles
- Gold and Silver Nanoparticles Synthesis and Applications
- Vector-borne infectious diseases
- Iron Metabolism and Disorders
- Quantum Dots Synthesis And Properties
- Insect and Pesticide Research
- Nanoplatforms for cancer theranostics
- Iron oxide chemistry and applications
- Entomopathogenic Microorganisms in Pest Control
- Biosensors and Analytical Detection
- Photoacoustic and Ultrasonic Imaging
- Proteins in Food Systems
- Advanced Nanomaterials in Catalysis
- Microfluidic and Bio-sensing Technologies
- Magnetic Properties and Synthesis of Ferrites
- Luminescence Properties of Advanced Materials
- Advanced Sensor and Energy Harvesting Materials
- Agricultural and Food Sciences
- Ferroelectric and Piezoelectric Materials
- Nanocluster Synthesis and Applications
- Mechanical and Optical Resonators
- Endoplasmic Reticulum Stress and Disease
- Acoustic Wave Resonator Technologies
- Health, Environment, Cognitive Aging
Universidad de Zaragoza
2020-2025
Instituto de Nanociencia y Materiales de Aragón
2020-2025
Instituto de Ciencia de Materiales de Madrid
2025
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2022-2024
Instituto de Estudios Avanzados
2020
Centro de Aplicaciones Tecnológicas y Desarrollo Nuclear
2017
Herein, we have developed nanohybrids (nHs) to remotely activate a therapeutic enzyme for its use in Directed Enzyme Prodrug Therapy (DEPT). The coencapsulation of magnetic nanoparticles (MNPs) with horseradish peroxidase (HRP) using biomimetic silica as an entrapment matrix was optimized obtain nanosized hybrids (∼150 nm) remote activation the enzyme. HRP converts indole-3-acetic acid (3IAA) into peroxylated radicals, whereas MNPs respond alternating fields (AMFs) becoming local hotspots....
In this study, we report the synthesis of gold-coated iron oxide nanoparticles capped with polyvinylpyrrolidone (Fe@Au NPs). The as-synthesized (NPs) exhibited good stability in aqueous media and excellent features as contrast agents (CA) for both magnetic resonance imaging (MRI) X-ray computed tomography (CT). Additionally, due to presence local surface plasmon resonances gold, NPs showed exploitable “light-to-heat” conversion ability near-infrared (NIR) region, a key attribute effective...
Magnetic hyperthermia (MH) was used to treat a murine model of pancreatic cancer. This type cancer is generally characterized by the presence dense stroma that acts as barrier for chemotherapeutic treatments. Several alternating magnetic field (AMF) conditions were evaluated using three-dimensional (3D) cell culture models loaded with nanoparticles (MNPs) determine which producing strong effect on viability. Once optimal AMF selected, in vivo experiments carried out similar frequency and...
Abstract Manganese ferrite nanoparticles display interesting features in bioimaging and catalytic therapies. They have been recently used theranostics as contrast agents magnetic resonance imaging (MRI), catalase‐mimicking nanozymes for hypoxia alleviation. These promising applications encourage the development of novel synthetic procedures to enhance properties these nanomaterials simultaneously. Herein, a cost‐efficient microwave method is developed manufacture ultrasmall manganese...
The surface coating of iron oxide magnetic nanoparticle (MNPs) drives their intracellular trafficking and degradation in endolysosomes, as well dictating other cellular outcomes. As such, we assessed whether MNP coatings might influence biodistribution, accumulation certain organs turnover therein, processes that must be understood vivo to optimize the design nanoformulations for specific therapeutic/diagnostic needs.In this study, three different were analyzed, each conferring identical 12...
Magnetic hyperthermia is a cancer treatment based on the exposure of magnetic nanoparticles to an alternating field in order generate local heat. In this work, 3D cell culture models were prepared observe effect that different number internalized particles had mechanisms death triggered upon treatment. Macrophages selected by their high capacity uptake nanoparticles. Intracellular nanoparticle concentrations up 7.5 pg Fe/cell measured both elemental analysis and characterization techniques....
Deciphering the most suitable shape to improve magnetocaloric effect of superparamagnetic iron oxide nanoparticles (SPIONs) for in vivo magnetic hyperthermia therapy (MHT) high-grade gliomas.
This work aims at studying how the transformations that magnetic nanoparticles suffer in vivo affect their heating properties frame of hyperthermia treatments. Iron oxide (≈13 nm) with two different coatings [PMAO (polymaleic anhydride-alt-1-octadecene) and DMSA (dimercaptosuccinic acid)] have been subjected to an accelerated degradation a medium simulating lysosome conditions. The particles physicochemical (size, size distribution, properties) followed over process along 24 days. It was...
Probiotic bacteria were used as carriers of metallic nanoparticles to develop innovative oral agents for hyperthermia cancer therapy. Two synthetic strategies produce the different therapeutic agents. First, probiotic bacterium Lactobacillus fermentum was simultaneously loaded with magnetic (MNPs) and gold (AuNPs) morphologies AuNP + MNP-bacteria systems both types arranged in same layer bacterial exopolysaccharides (EPS). In second approach, first form AuNP-bacteria subsequently MNP-EPS...
Magnetic nanoparticles, especially iron oxide have become versatile and widely used tools in nanomedicine due to their unique magnetic properties, biocompatibility, tunable functionality. Liposomes further enhanced the potential of nanoparticles by serving as effective nanocarriers with advantages such drug coencapsulation molecular imaging properties. In this study, we present magnetoliposomes composed ultrasmall free-floating inside liposomes (LP-IONPs) thermoresponsive phospholipids,...
The protein corona composition, rather than core size or hydrodynamic diameter, predominantly determines the biodistribution, uptake rate, and bioavailability of iron oxide nanoparticles.
We describe a wet chemical method for the synthesis of uniform and well-dispersed dysprosium vanadate (DyVO4) holmium (HoVO4) nanoparticles with an almost spherical shape mean size ∼60 nm their functionalization poly(acrylic acid). The transverse magnetic relaxivity both systems at 9.4 T is analyzed on basis susceptibility magnetization measurements in order to evaluate potential application as high-field MRI contrast agents. In addition, X-ray attenuation properties these are also studied...
The development of nanoplatforms prepared to perform both multimodal imaging and combined therapies in a single entity is fast-growing field. These systems are able improve diagnostic accuracy therapy success. Multicomponent Nanoparticles (MCNPs), composed iron oxide gold, offer new opportunities for Magnetic Resonance Imaging (MRI) Computed Tomography (CT) diagnosis, as well based on Hyperthermia (MH) Photothermal Therapy (PT). In this work, we describe seed-assisted method the synthesis...
Iron oxide nanoparticles (IONPs) have become one of the most promising nanomaterials for biomedical applications because their biocompatibility and physicochemical properties. This study demonstrates use protein engineering as a novel approach to design scaffolds tunable synthesis ultrasmall IONPs. Rationally designed proteins, containing different number metal-coordination sites, were evaluated control size magnetic properties set protein-stabilized IONPs (Prot-IONPs). Prot-IONPs,...
Abstract Heating magnetic nanoparticles (MNPs) with AC (Alternating Current) fields has received significant attention in recent years, particularly for biomedical uses. However, most studies focus on characterizing the heat release, overlooking fact that MNPs viscous cell environment constitute a dynamic colloid whose configuration may evolve over time, if driving force as field is applied. Aiming to shed light this matter, workthe dynamics of structure during hyperthermia experiments are...
Accurate knowledge of the heating performance magnetic nanoparticles (MNPs) under AC fields is critical for development hyperthermia-mediated applications.
The photothermal properties of a collection magnetic nanoparticles were analyzed. One these sets particles was further tested in vitro triggering cell death after 10 minutes laser exposure.
The impedance properties in polarized piezoelectric can be described by electric equivalent circuits. classic circuit used the literature to describe real systems is formed one resistor (R), inductance (L) and capacitance C connected series capacity ([Formula: see text]) parallel with formers. Nevertheless, equation that resonance anti-resonance frequencies depends on a complex manner of R, L, [Formula: text]. In this work proposed simpler model (C) series; parallel; other components. Unlike...
Abstract Advanced uses of smartphones are changing lifestyles, and may have a great impact in materials science the near future. In this work, use these devices to develop fast, simple, cheap methods characterize magnetic nanoparticle suspensions is tested. A series dilutions wide library nanoparticles, composed iron oxide range between 3 43 nm, with two different shapes four coatings prepared. The colloid color analyzed using RGB (red, green, blue) model. Ratios parameters correlated...
Accurate knowledge of the heating performance magnetic nanoparticles (MNPs) under AC fields is critical for development hyperthermia-mediated applications. Usually reported in terms specific loss power (SLP) obtained from temperature variation ($\Delta{T}$) vs. time (t) curve, such estimate subjected to a huge uncertainty. Thus, very different SLP values are same particles when measured on equipment/laboratories. This lack control clearly hampers further MNP-mediated heat-triggered...