A5070095101- Nanoparticle-Based Drug Delivery
- Characterization and Applications of Magnetic Nanoparticles
- Iron oxide chemistry and applications
- Advanced biosensing and bioanalysis techniques
- Advanced Biosensing Techniques and Applications
- Atomic and Subatomic Physics Research
- Click Chemistry and Applications
- Monoclonal and Polyclonal Antibodies Research
- Nanoplatforms for cancer theranostics
- Cerebrovascular and Carotid Artery Diseases
- Radiopharmaceutical Chemistry and Applications
- S100 Proteins and Annexins
- Parathyroid Disorders and Treatments
- Advanced NMR Techniques and Applications
- Advanced Radiotherapy Techniques
- Atherosclerosis and Cardiovascular Diseases
- Advanced MRI Techniques and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Alzheimer's disease research and treatments
- Water Quality Monitoring Technologies
- Cholesterol and Lipid Metabolism
- Phagocytosis and Immune Regulation
- Radiation Therapy and Dosimetry
- ATP Synthase and ATPases Research
- Connective tissue disorders research
Instituto de Química Médica
2019-2024
Universidad Complutense de Madrid
2019-2023
Consejo Superior de Investigaciones Científicas
2019-2023
VinTech (United States)
2020
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2017-2019
Centro de Investigación Biomédica en Red
2016-2019
Spanish National Centre for Cardiovascular Research
2016-2018
Iron oxide nanoparticles have been extensively utilised as negative (T2) contrast agents in magnetic resonance imaging. In the past few years, researchers also exploited their application positive (T1) to overcome limitation of traditional Gd3+ agents. To provide T1 contrast, these particles must present certain physicochemical properties with control over size, morphology and surface particles. this review, we summarise reported iron critically revise properties, synthetic protocols...
Iron oxide nanomaterial is a typical example of magnetic resonance imaging probe for negative contrast. It has also been shown how this can be synthesized positive contrast by modification the composition and size core. However, role organic coating in relaxometric properties largely unexplored. Here, maghemite nanoparticles with either excellent or very good performance are obtained modifying thickness while core kept unchanged. Different tailored features as agent according to layer have...
In vivo detection and quantification of inflammation is a major goal in molecular imaging. Furthermore, cell-specific would be tremendous advantage the characterization many diseases. Here, we show how this can achieved through synergistic combination nanotechnology nuclear One most remarkable features hybrid approach possibility to tailor pharmacokinetics nanomaterial-incorporated biomolecule radionuclide. A good example covalent binding large amount neutrophil-specific, hydrophobic peptide...
Synthesizing iron oxide nanoparticles for positive contrast in magnetic resonance imaging is the most promising approach to bring this nanomaterial back clinical field. The success of depends on several aspects: longitudinal relaxivity values, complexity synthetic protocol, and reproducibility synthesis. Here, we show our latest results goal. We have studied effect Cu doping physicochemical, magnetic, relaxometric properties designed provide imaging. used a one-step, 10 min synthesis produce...
Vascular microcalcifications are associated with atherosclerosis plaque instability and, therefore, to increased mortality. Because of this key role, several imaging probes have been developed for their in vivo identification. Among them, [18F]FNa is the gold standard, showing a large uptake whole skeleton by positron emission tomography. Here, we push field toward combined anatomical and functional early characterization atherosclerosis. For this, hydroxyapatite (HAP)-multitag,...
The combination of radioisotopes and nanomaterials is creating a new library tracers for molecular imaging, exploiting the sensitivity nuclear imaging techniques size-dependent properties nanomaterials. This approach expanding range applications, including possibility theranostics. Among many different combinations, use 68Ga as radioisotope in radio-nanomaterial particularly convenient. physicochemical this isotope allow incorporating it into materials with great chemical flexibility....
Proton therapy allows the treatment of specific areas and avoids surrounding tissues. However, this technique has uncertainties in terms distal dose fall-off. A promising approach to studying proton range is use nanoparticles as proton-activatable agents that produce detectable signals. For this, we developed an iron oxide nanoparticle doped with Zn (IONP@Zn-cit) a hydrodynamic size 10 nm stability serum. Cytotoxicity, defined half surveillance, was 100 μg Zn/mL U251 cell line. The effect on...
<sup>68</sup>Ga-core doped iron oxide nanoparticles permit the rapid detection of thrombi in brain by fast pretargeting imaging.
Abstract Advanced uses of smartphones are changing lifestyles, and may have a great impact in materials science the near future. In this work, use these devices to develop fast, simple, cheap methods characterize magnetic nanoparticle suspensions is tested. A series dilutions wide library nanoparticles, composed iron oxide range between 3 43 nm, with two different shapes four coatings prepared. The colloid color analyzed using RGB (red, green, blue) model. Ratios parameters correlated...
We have recently described a novel family of compounds reduced size and dual anti-HIV anti-EV71 activity that encompasses tripodal tetrapodal derivatives. The prototype, AL-470, has nitro group at the focal point central scaffold three attached tryptophan residues, each which bearing an isophthaloyl moiety C2 position indole ring. A to amino substitution allowed us now introduce chemically addressable functionality perform further structural modifications consisting both direct...
Here, we describe a microwave synthesis to obtain iron oxide nanoparticles core-doped with 68Ga. Microwave technology enables fast and reproducible synthetic procedures. In this case, starting from FeCl3 citrate trisodium salt, coated citric acid are obtained in 10 min the microwave. These present small core size of 4.2 ± 1.1 nm hydrodynamic 7.5 2.1 nm. Moreover, they have high longitudinal relaxivity (r1) value 11.9 mM-1·s-1 modest transversal (r2) 22.9 mM-1·s-1, which results low r2/r1...
Atherosclerosis, a leading cause of cardiovascular diseases requires approaches to enhance disease monitoring and treatment. Nanoparticles offer promising potential in this area by being customisable target components or molecular processes within plaques, while carrying diagnostic therapeutic agents. However, the number biomarkers available is limited. This study investigated use sphingomyelin-based nanomicelles triggered sphingomyelinase (SMase) atherosclerotic plaques. Accumulation iron...
Sphingomyelinase enzymatic activity destabilises iron oxide nanomicelles and promotes its accumulation in atherosclerosis vivo .
Abstract Background Alzheimer’s disease (AD) is the most common cause of dementia (1). It a multifactorial degenerative pathologically characterized by intracellular neurofibrillary tangles and extracellular deposition amyloid. An early haemostatic dysregulation also present contributes to an increment in clot formation, leading hypoperfusion, blood brain barrier disruption neuronal loss (2). The detection this prothrombotic state upmost importance diagnostic approaches identify AD patients...
ABSTRACT Vascular microcalcifications are associated with atherosclerosis plaque instability and, therefore, to increased mortality. Because of this key role, several imaging probes have been developed for their in vivo identification. Among them [ 18 F]FNa is the gold standard, showing a large uptake whole skeleton. Here, we push field towards combined anatomical and functional early characterization atherosclerosis. For that, HAP-multitag, bisphosphonate-functionalized 68 Ga magnetic...
Background: Alzheimer’s disease (AD) is the most common cause of dementia. It a multifactorial degenerative pathologically characterized by intracellular neurofibrillary tangles and extracellular deposition amyloid. An early hemostatic dysregulation also present contributes to an increment in clot formation, leading hypoperfusion, blood brain barrier disruption neuronal loss. The detection this prothrombotic state upmost importance diagnostic approaches identify AD patients who would benefit...