A5101874669- Radiopharmaceutical Chemistry and Applications
- Peptidase Inhibition and Analysis
- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Employment, Labor, and Gender Studies
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Radiation Therapy and Dosimetry
- Labor Law and Work Dynamics
- Social Sciences and Policies
- Stress Responses and Cortisol
- Medical Imaging Techniques and Applications
- Advanced Radiotherapy Techniques
- Health and Lifestyle Studies
- Radiomics and Machine Learning in Medical Imaging
- Radiation Dose and Imaging
- Retirement, Disability, and Employment
- Aging, Health, and Disability
- Protease and Inhibitor Mechanisms
- Employment and Welfare Studies
- Boron Compounds in Chemistry
- Neurotransmitter Receptor Influence on Behavior
- Medical Imaging and Pathology Studies
- Health and Medical Education
- Pancreatic and Hepatic Oncology Research
Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas
2018-2024
Centre for Research and Technology Hellas
2020-2021
Universidad de Oviedo
2020
Triple-negative breast cancer (TNBC) is a highly aggressive subtype of that lacks effective diagnostic and therapeutic options. Membrane type 1 matrix metalloproteinase (MT1-MMP) an attractive biomarker for improving patient selection. This study aimed to develop theranostic tool using tumour-selective anti-MT1-MMP antibody (LEM2/15) radiolabelled with
Abstract Radionuclide generator systems can routinely provide radionuclides on demand such as 68 Ga produced by a Ge/ without the availability of an on-site accelerator or research reactor. Thus, in this work nano-SnO 2 was used to develop new which evaluated over period 17 months and 305 elution cycles. The yield 91.1 ± 1.8% first 7 mL (1 M HCl eluent) when then it decreased with time use 73.8 1.9%. Around 80% elutable activity obtained 1 Ge content eluate did not exceed × 10 –4 %...
Abstract Substance use disorders are more prevalent in schizophrenia, but the causal links between both conditions remain unclear. Maternal immune activation (MIA) is associated with schizophrenia which may be triggered by stressful experiences during adolescence. Therefore, we used a double-hit rat model, combining MIA and peripubertal stress (PUS), to study cocaine addiction underlying neurobehavioural alterations. We injected lipopolysaccharide or saline on gestational days 15 16...
Proton therapy allows the treatment of specific areas and avoids surrounding tissues. However, this technique has uncertainties in terms distal dose fall-off. A promising approach to studying proton range is use nanoparticles as proton-activatable agents that produce detectable signals. For this, we developed an iron oxide nanoparticle doped with Zn (IONP@Zn-cit) a hydrodynamic size 10 nm stability serum. Cytotoxicity, defined half surveillance, was 100 μg Zn/mL U251 cell line. The effect on...
Pancreatic ductal adenocarcinoma (PDAC) continues to be one of the deadliest cancers for which optimal diagnostic tools are still greatly needed. Identification PDAC-specific molecular markers would extremely useful improve disease diagnosis and follow-up. MT1-MMP has long been involved in pancreatic cancer, especially tumour invasion metastasis. In this study, we aim ascertain suitability as a biomarker positron emission tomography (PET) imaging. Two probes were assessed compared purpose,...
Several studies performed on human subjects have examined the effects of adolescent cannabis consumption brain structure or function using imaging techniques. However, evidence from these is usually heterogenous and affected by several confounding variables. Animal models cannabinoid exposure may help to overcome difficulties. In this exploratory study, we aim increase our understanding protracted Δ9-tetrahydrocannabinol (THC) in rats both sexes magnetic resonance (MR) obtain volumetric...
Frente a la idea general de que segregación ocupacional es un fenómeno en retroceso, se comprueba su aumento España entre los Censos 2001 y 2011. Replicando una investigación anterior (Ibáñez, 2008), comparan resultados Encuesta Población Activa (EPA) Estructuras Salariales (EES). Los invitan adoptar perspectiva compleja, subrayan preocupante permanencia laboral femenina. Las mujeres no han conseguido entrar ni ocupaciones tradicionalmente masculinas cualificadas pero con altas...
Estudiar los efectos del consumo de tabaco (producto adictivo) en la salud pacientes sigue siendo una prioridad para sociedad. Tras lectura âLa Historia Medicinal las cosas que se traen nuestras Indias Occidentalesâ Nicolás Monardes realizó lista todos beneficios le atribuÃan al tabaco. Uno pocos no han sido refutados es el dolor muelas. Por ello objetivo estudio relacionar con bucodental (caries) replicar afirmación Monardes. Estudio piloto acuden dentista área La Rioja Alta...
Abstract Substance use disorders are more prevalent in schizophrenia, worsening its course and prognosis. Here, we used a double-hit rat model, combining maternal immune activation (MIA) peripubertal stress (PUS), to study cocaine addiction the underlying neurobehavioural alterations. We injected lipopolysaccharide or saline on gestational days 15 16 pregnant rats. Their male offspring were then subjected 5 episodes of unpredictable every other day during adolescence (from postnatal 28 38)....
This paper shows the current poverty rate (relative and absolute) how far different features (personal, coexistence employment) are associated with this situation. Furthermore, it considers influence of economic crisis (2009-2013) in a possible change relative importance these features. To do this, absolute rates Spain analysed using two Eurostat indicators: risk severe material deprivation, through Survey on Living Conditions (ECV) by Spanish statistical body INE. The results show is useful...
ABSTRACT Cannabis is widely consumed by adolescents, and also a potential prior step leading to the use of other drugs later in life (Gateway Hypothesis); however, evidence for this hypothesis controversial. This work aimed increase our understanding long-term consequences adolescent exposure Δ 9 -tetrahydrocannabinol (THC) test Gateway Hypothesis, experimentally. We exposed rats both sexes THC studied its effects on reward-related processes, brain morphology (MRI), metabolism ( 1 H-MRS),...