A5028645888- Nanoparticle-Based Drug Delivery
- Gold and Silver Nanoparticles Synthesis and Applications
- Lanthanide and Transition Metal Complexes
- Characterization and Applications of Magnetic Nanoparticles
- Nanoplatforms for cancer theranostics
- Luminescence Properties of Advanced Materials
- Advanced MRI Techniques and Applications
- Organizational Management and Innovation
- Atomic and Subatomic Physics Research
- Business, Education, Mathematics Research
- Nanocluster Synthesis and Applications
- Orbital Angular Momentum in Optics
- Biosensors and Analytical Detection
- Advanced biosensing and bioanalysis techniques
- X-ray Diffraction in Crystallography
- Nanoparticles: synthesis and applications
- Crystallization and Solubility Studies
- Graphene and Nanomaterials Applications
- Advanced Nanomaterials in Catalysis
- Business, Innovation, and Economy
- Accounting and Financial Management
- Higher Education Teaching and Evaluation
- Laser-Ablation Synthesis of Nanoparticles
- Iron oxide chemistry and applications
- Knowledge Societies in the 21st Century
Fundación Progreso y Salud
2023-2025
Instituto de Investigación Biomédica de Málaga
2022-2025
Andalusian Centre for Nanomedicine and Biotechnology
2017-2024
Junta de Andalucía
2017-2024
Universidad de Málaga
2017-2024
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2020-2024
Instituto de Salud Carlos III
2024
Universidad Complutense de Madrid
2023
Centro de Investigación Biomédica en Red
2022
Centro Médico Sanitas Málaga
2021
Passive tumor targeting via the enhanced permeability and retention (EPR) effect has long been considered most effective mechanism for accumulation of nanoparticles inside solid tumors. However, several studies have demonstrated that EPR is largely dependent on type location. Particularly complex situation in brain tumors, where presence blood-brain barrier (BBTB) adds an extra limiting factor reaching interstitium. it remains unclear whether these restraints imposed by BBTB prevent from...
In this study, we report the synthesis of gold-coated iron oxide nanoparticles capped with polyvinylpyrrolidone (Fe@Au NPs). The as-synthesized (NPs) exhibited good stability in aqueous media and excellent features as contrast agents (CA) for both magnetic resonance imaging (MRI) X-ray computed tomography (CT). Additionally, due to presence local surface plasmon resonances gold, NPs showed exploitable “light-to-heat” conversion ability near-infrared (NIR) region, a key attribute effective...
Abstract Iron Oxide Nanoparticles (IONPs) hold the potential to exert significant influence on fighting cancer through their theranostics capabilities as contrast agents (CAs) for magnetic resonance imaging (MRI) and mediators hyperthermia (MH). In addition, these can be improved by doping IONPs with other elements. this work, synthesis characterization of single‐core alloy ZnFe novel nanoparticles (MNPs), properties more efficient magnetic‐to‐heat conversion, are reported. Remarkably,...
Capped silver nanoparticles that can be coupled to a variety of molecules and biomolecules are great interest owing their potential applications in biomedicine. However, there no data about toxicity or functional effects on key innate immune response, such as IL-6 secretion, after the engagement main group pathogen-associated molecular patterns receptors, is, Toll-like receptors (TLRs).N-(2-mercaptopropionyl)glycine (tiopronin)-capped (Ag@tiopronin) narrow sized distribution ( approximately...
Abstract We study the selective catalytic oxidation of ethanol with air as a sustainable alternative route to acetaldehyde. The reaction is catalysed by molybdenum oxide supported on titania, in flow reactor under ambient pressure. High selectivity acetaldehyde (70%–89%, depending Mo loading) obtained at 150 °C. Subsequently, we investigate structure/performance relationship for various species using combination techniques including diffuse reflectance UV‐visible, infrared, X‐ray...
This work reports on highly efficient surface enhanced Raman spectroscopy (SERS) constructed low-cost, fully recyclable and reproducible cardboard plates, which are commonly used as disposable packaging material. The active optical component is based plasmonic silver nanoparticle structures separated from the metal of by a nanoscale dielectric gap. SERS response (Ag) nanoparticles various shapes sizes were systematically investigated, enhancement factor higher than 106 for rhodamine 6G...
In this work, we report the synthesis and characterization of three magnetic nanosystems, CoFe2O4, CoFe2O4@ZnFe2O4, CoFe2O4@MnFe2O4, which were developed as potential theranostic agents for hyperthermia resonance imaging (MRI). These nanosystems have been thoroughly characterized by X-ray Diffraction (XRD), Transmission Electron Miscroscopy (TEM), Dark Field-TEM (DF-TEM), Vibrating Sample Magnetometry (VSM), inductive heating, in order to elucidate their structure, morphology, properties....
Chitosan-functionalized magnetite/poly(ε-caprolactone) nanoparticles were formulated by interfacial polymer disposition plus coacervation, and loaded with gemcitabine. That (core/shell)/shell nanostructure was confirmed electron microscopy, elemental analysis, electrophoretic, Fourier transform infrared characterizations. A short-term stability study proved the protection against particle aggregation provided chitosan shell. Superparamagnetic properties of characterized in vitro, while...
Deciphering the most suitable shape to improve magnetocaloric effect of superparamagnetic iron oxide nanoparticles (SPIONs) for in vivo magnetic hyperthermia therapy (MHT) high-grade gliomas.
Abstract Glioblastoma continues to pose a major global health challenge due its incurable nature. The need for new strategies combat this devastating tumor is therefore paramount. Nanotechnology offers unique opportunities develop innovative and more effective therapeutic approaches. However, most nanosystems developed treat glioblastomas, especially those based on metallic nanoparticles (NPs), have proven unsuccessful their inability efficiently target these tumors, which are particularly...
Abstract We report a novel method for the fabrication of films silver nanoparticle aggregates that are strongly attached to Si substrates (Thiol‐immobilized or TISNA). The attachment is achieved by chemically modifying surface Si(100) in order provide SH groups covalently linked substrate and then aggregating nanoparticles on these thiol covered surfaces. transmission electron microscopy (TEM), scanning (SEM) atomic force (AFM) characterization show high coverage with single small clusters...
Biocompatible and long-circulating (maghemite/poly(<sc>d</sc>,<sc>l</sc>-lactide-<italic>co</italic>-glycolide))/chitosan (core/shell)/shell nanoparticles with promising theranostic applications (biomedical imaging hyperthermia) against cancer.
The application of metal-based nanoparticles (mNPs) in cancer therapy and diagnostics (theranostics) has been a hot research topic since the early days nanotechnology, becoming even more relevant recent years. However, clinical translation this technology notably poor, with one main reasons being lack understanding disease conceptual errors design mNPs. Strikingly, throughout reported studies to date on vivo experiments, concepts "tumor targeting" cell are often intertwined, particularly...
Bimodal medical imaging based on magnetic resonance (MRI) and computed tomography (CT) is a well-known strategy to increase the diagnostic accuracy. The most recent advances in MRI CT instrumentation are related use of ultra-high fields (UHF-MRI) different working voltages (spectral CT), respectively. Such require parallel development bimodal contrast agents (CAs) that efficient under new instrumental conditions. In this work, we have synthesized, through precipitation reaction from glycerol...
Platinum nanomaterials are the focus of great expectations to expand reach modern sensor technology. In this work, we have evaluated ability different types platinum nanoparticles enhance response analytical techniques based on optical excitation methods, namely nanoparticle-assisted laser desorption/ionization (NALDI), Raman scattering (SERS), and infrared absorption (SEIRA). Physical (laser ablation) chemical (redox) methods synthesis been employed produce spherical particles with sizes...
pH-responsive nanogels (NGs) were used to prepare high-efficiency magnetic resonance imaging dual T1/T2 contrast agents for pH imaging. The polymeric NG matrix acts as a strong polydentate ligand that chelates the Mn cations in its inner cavity generating hybrid structure. chelate is sensitive changes, such protonation induces change of polymer hydration state and consequent swelling. swollen nanogel allows water molecules enter interact with chelate, shortening relaxation time (switch ON)...