A5064143930- Neonatal and fetal brain pathology
- Microfluidic and Capillary Electrophoresis Applications
- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Genetics and Neurodevelopmental Disorders
- Ubiquitin and proteasome pathways
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Electrowetting and Microfluidic Technologies
- 3D Printing in Biomedical Research
- Neuroscience and Neural Engineering
- Biosensors and Analytical Detection
- Cellular transport and secretion
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced biosensing and bioanalysis techniques
- RNA Research and Splicing
- Characterization and Applications of Magnetic Nanoparticles
- Signaling Pathways in Disease
- Microfluidic and Bio-sensing Technologies
- Luminescence Properties of Advanced Materials
- Down syndrome and intellectual disability research
- Atomic and Subatomic Physics Research
- Lanthanide and Transition Metal Complexes
- Photoreceptor and optogenetics research
Fundación Progreso y Salud
2024
Andalusian Centre for Nanomedicine and Biotechnology
2024
Instituto de Investigación Biomédica de Málaga
2024
Universidad de Málaga
2024
Universidad de Sevilla
2019-2022
Instituto de Biomedicina de Sevilla
2019-2020
Hospital Universitario Virgen del Rocío
2019-2020
Abstract Iron Oxide Nanoparticles (IONPs) hold the potential to exert significant influence on fighting cancer through their theranostics capabilities as contrast agents (CAs) for magnetic resonance imaging (MRI) and mediators hyperthermia (MH). In addition, these can be improved by doping IONPs with other elements. this work, synthesis characterization of single‐core alloy ZnFe novel nanoparticles (MNPs), properties more efficient magnetic‐to‐heat conversion, are reported. Remarkably,...
The application of metal-based nanoparticles (mNPs) in cancer therapy and diagnostics (theranostics) has been a hot research topic since the early days nanotechnology, becoming even more relevant recent years. However, clinical translation this technology notably poor, with one main reasons being lack understanding disease conceptual errors design mNPs. Strikingly, throughout reported studies to date on vivo experiments, concepts "tumor targeting" cell are often intertwined, particularly...
Abstract Down syndrome (DS) is the most frequent genetic cause of intellectual disability including hippocampal-dependent memory deficits. We have previously reported hippocampal mTOR (mammalian target rapamycin) hyperactivation, and related plasticity as well deficits in Ts1Cje mice, a DS experimental model. Here we characterize proteome synaptoneurosomes (SNs) from these found predicted alteration synaptic pathways, long term depression (LTD). Accordingly, mGluR-LTD (metabotropic Glutamate...
NaLn(WO 4 ) 2 (Ln = Dy or Ho) nanoparticles functionalized with polyacrylic acid exhibit excellent performance as bimodal contrast agents for high-field MRI and X-ray computed tomography bioimaging show tumor targeting ability through the EPR effect.
Printed circuit board (PCB) technology is well known, reliable, and low-cost, its application to biomedicine, which implies the integration of microfluidics electronics, has led Lab-on-PCB. However, biocompatibility involved materials be examined if they are in contact with biological elements. In this paper, solder mask (PSR-2000 CD02G/CA-25 CD01, Taiyo Ink (Suzhou) Co., Ltd., Suzhou, China) a commercial PCB been studied for retinal cultures. For purpose, explants have cultured over...
In this paper, a prototype of semi-automatic lab-on-PCB for agarose gel preparation and electrophoresis is developed. The dimensions the device are 38 × 34 mm2 it includes conductivity sensor detecting TAE buffer (Tris-acetate-EDTA buffer), microheater increasing solubility agarose, negative temperature coefficient (NTC) thermistor controlling temperature, light dependent resistor (LDR) measuring transparency mixture, two electrodes performing electrophoresis. functions governed by...
In this paper, a prototype of an automatic lab on PCB for agarose preparation and electrophoresis is developed. The dimensions the device are 38×34 mm2 includes conductivity sensor detecting TAE buffer (Tris-Acetate-EDTA buffer), microheater mixing, NTC thermistor controlling temperature, LDR measuring transparency mixture, two electrodes performing electrophoresis. functions governed by microcontroller. requires PMMA structure to define wells gel, release from agarose. maximum...
In this paper an automatic lab-on-PCB system with pre-stored reagents is described. The releasing method of the biocompatible, easy to perform, and free debris. addition, fabrication process scalable mass production. PCB-chip consists a PMMA microfluidic circuit, commercial Printed Circuit Board (PCB) integrated sensors actuators. quantity reagent moved toward circuit programmable. requires reader for controlling whole process. experimental results show correct functioning device storing...
Biologists and physicians need tools that may study the biological mechanisms involved in degeneration of tissues to understand slow down effects diseases. In this way, systems able maintain a culture its appropriate conditions, even long term, compatible with electro-stimulation acquisition, open wide field applications. The proposed design is low-cost portable system accomplishes all these requirements. It based on integration an MEA electronic systems, platform, offering possibility cell...
ABSTRACT Down syndrome (DS) is the most frequent genetic cause of intellectual disability including hippocampal-dependent memory deficits. We have previously reported hippocampal mTOR (mammalian target rapamycin) hyperactivation, and related plasticity as well deficits in Ts1Cje mice, a DS experimental model. Here we report that performance mice novel object recognition (NOR) impaired, but it ameliorated by rapamycin treatment. Proteome characterization synaptoneurosomes (SNs) from these...