A5019139059- Chemical Reactions and Mechanisms
- Chemical synthesis and pharmacological studies
- Synthesis and Biological Evaluation
- Chemical Reaction Mechanisms
- Organic Chemistry Cycloaddition Reactions
- Synthesis and Catalytic Reactions
- Synthesis and Reactions of Organic Compounds
- Advanced Chemical Physics Studies
- Synthesis of heterocyclic compounds
- Inorganic and Organometallic Chemistry
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cyclopropane Reaction Mechanisms
- Photochemistry and Electron Transfer Studies
- Synthesis of Tetrazole Derivatives
- Synthesis and Reactivity of Heterocycles
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Characterization of Pyrroles
- Synthesis of β-Lactam Compounds
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Fluorine in Organic Chemistry
- Chemistry and Chemical Engineering
- Chemical Synthesis and Analysis
- Molecular Spectroscopy and Structure
- Cyclization and Aryne Chemistry
The University of Queensland
2015-2024
University of Lausanne
1980-2021
University of Copenhagen
2011-2021
Université de Pau et des Pays de l'Adour
2014-2021
Weatherford College
2020
Robert Bosch (Germany)
2020
Philipps University of Marburg
1980-2019
Soochow University
2019
Carl von Ossietzky Universität Oldenburg
2000-2015
Brisbane School of Theology
2015
The structures and reactivities of nitrile imines are subjects continuing debate. Several were generated photochemically or thermally investigated by IR spectroscopy in Ar matrices at cryogenic temperatures (Ph-CNN-H 6, Ph-CNN-CH(3)17, Ph-CNN-SiMe(3)23, Ph-CNN-Ph 29, Ph(3)C-CNN-CPh(3)34, the boryl-CNN-boryl derivative 39). effect substituents on absorptions was computationally B3LYP/6-31G* level. spectra analyzed terms calculated anharmonic vibrational generally very good agreement with...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBenzyne, cyclohexyne, and 3-azacyclohexyne the problem of cycloalkyne versus cycloalkylideneketene genesisCurt. Wentrup, Rodney. Blanch, Horst. Briehl, Gerhard. GrossCite this: J. Am. Chem. Soc. 1988, 110, 6, 1874–1880Publication Date (Print):March 1, 1988Publication History Published online1 May 2002Published inissue 1 March 1988https://pubs.acs.org/doi/10.1021/ja00214a034https://doi.org/10.1021/ja00214a034research-articleACS PublicationsRequest...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTautomeric equilibrium and hydrogen shifts of tetrazole in the gas phase solutionMing Wah Wong, Regis Leung-Toung, Curt WentrupCite this: J. Am. Chem. Soc. 1993, 115, 6, 2465–2472Publication Date (Print):March 1, 1993Publication History Published online1 May 2002Published inissue 1 March 1993https://pubs.acs.org/doi/10.1021/ja00059a048https://doi.org/10.1021/ja00059a048research-articleACS PublicationsRequest reuse permissionsArticle...
This review describes the methods of generation α-oxoketenes and their use in synthesis. While ketenes are often generated situ without direct proof for existence, used observation also emphasized. The most important classes precursor molecules 2-diazo-1, 3-diketones,1,3-dioxin-4-ones, 2,3-dihydrofuran-2,3-diones, β-ketoacid derivatives. Synthetically useful reactions nucleophilic additions to give carboxylic acid derivatives which can be subjected further functional group manipulation, [2 +...
Ab initio calculations at the G2(MP2,SVP) and B-LYP/6-311+G(3df,2p)+ZPVE levels have been used to examine potential energy surface of C(7)H(6). Fulvenallene (6) is most stable C(7)H(6) isomer considered in this study. 1-Ethynylcyclopentadiene (9A), benzocyclopropene (10), 1,2,4,6-cycloheptatetraene (4) lie 12, 29, 49 kJ mol(-)(1), respectively, above 6. Phenylcarbene (1) calculated a triplet ((3)A") ground state, 16 mol(-)(1) more than singlet state ((1)A'). Interconversion 1 4 predicted...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsolation of diazacycloheptatetraenes from thermal nitrene-nitrene rearrangementsCurt Wentrup and Hans Wilhelm WinterCite this: J. Am. Chem. Soc. 1980, 102, 19, 6159–6161Publication Date (Print):September 1, 1980Publication History Published online1 May 2002Published inissue 1 September 1980https://pubs.acs.org/doi/10.1021/ja00539a039https://doi.org/10.1021/ja00539a039research-articleACS PublicationsRequest reuse permissionsArticle...
Rearrangements of aromatic and heteroaromatic nitrenes carbenes can be initiated with either heat or light. The thermal reaction is typically induced by flash vacuum thermolysis, isolation the products at low temperatures. Photochemical experiments are conducted under matrix conditions in solution ambient temperature. These rearrangements usually ring expansion nitrene carbene to a seven-membered ketenimine, carbodiimide, allene (that is, cycloheptatetraene an azacycloheptatetraene when...
The history of o-benzyne from its early beginnings as an unobservable reactive intermediate until present status a very well characterized but still theoretically challenging molecule with important applications in synthesis is reviewed. m- and p-benzynes, tridehydrobenzenes, benzdiynes are also known, p-benzyne key the action potent class ene-diyne anti-tumour compounds.
Abstract Variable‐temperature NMR and ESR spectroscopic studies reveal that bis(dibenzo[a,i]fluorenylidene) 1 possesses a singlet ground state, (S 0 ), while the 90° twisted triplet (T ) is populated to small extent already at room temperature. Analysis of increasing amount paramagnetic temperatures between 300 500 K yields exchange interaction J ex / h c =3351 cm −1 singlet–triplet energy splitting 9.6 kcal mol , which in excellent agreement with calculations (9.3 UKS BP86/B3LYP/revPBE...
Abstract The words organic and synthesis originate with Aristotle (meaning ‘instrumental’ ‘put together’, respectively) but had different meanings over time. iatrochemists prepared numerous pharmaceutical remedies in the 1600s no concept of chemistry. Buffon, Bergman Gren defined bodies as living things 1700s, discrete compounds remained unknown. In late 1700s early 1800s, natural products were isolated by Scheele, Chevreuil separated carboxylic acids from saponification fats. Organic...
Abstract The concept of 1,3‐dipolar cycloaddition was developed, starting in the late 1950s, largely by Rolf Huisgen and his students Munich, it has led to one most versatile methods for construction five‐membered ring heterocycles. Although first known only as transient intermediates, nitrile imines have been at heart mechanistic studies this type reactions. Hundreds papers appeared 1960s 1970s; reliable spectroscopic observations were achieved early 1980s both low temperatures gas phase;...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactive nitrogenous molecules from Meldrum's acid derivatives, pyrrole-2,3-diones, and isoxazolonesHorst Briehl, Adelheid Lukosch, Curt WentrupCite this: J. Org. Chem. 1984, 49, 15, 2772–2779Publication Date (Print):July 1, 1984Publication History Published online1 May 2002Published inissue 1 July 1984https://pubs.acs.org/doi/10.1021/jo00189a025https://doi.org/10.1021/jo00189a025research-articleACS PublicationsRequest reuse permissionsArticle...
The fascinating carbene-nitrene rearrangement can be observed directly by ESR spectroscopy. In the thermal decomposition of carbene precursor 4 (via 3) with subsequent matrix isolation, product gave same signal as phenylnitrene 2 from phenylazide 1! aza-analogous system, seven-membered 5 is probably formed intermediate rearrangemet.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynergic nucleophilic and electrophilic properties of carbenes. Synthesis carbazoles, azafluorenes, .delta.-carbolines, pyrido- pyrimido[2,1-a]isoindoles by carbene rearrangement. Tracer studies the mechanisms an analysis carbon-13 NMR spectra azafluorenesClaude Mayor Curt WentrupCite this: J. Am. Chem. Soc. 1975, 97, 26, 7467–7480Publication Date (Print):December 1, 1975Publication History Published online1 May 2002Published inissue 1 December...