A5014971560- Sarcoma Diagnosis and Treatment
- Soft tissue tumor case studies
- Tumors and Oncological Cases
- Vascular Tumors and Angiosarcomas
- Bone Tumor Diagnosis and Treatments
- Histiocytic Disorders and Treatments
- Chromatin Remodeling and Cancer
- Cardiac tumors and thrombi
- Urologic and reproductive health conditions
- Cancer, Hypoxia, and Metabolism
- Amino Acid Enzymes and Metabolism
- Vascular Malformations and Hemangiomas
- Cancer and Skin Lesions
- Ovarian cancer diagnosis and treatment
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Radiopharmaceutical Chemistry and Applications
- Metabolism and Genetic Disorders
- CAR-T cell therapy research
- Endometrial and Cervical Cancer Treatments
- Gestational Trophoblastic Disease Studies
- Intraperitoneal and Appendiceal Malignancies
- Cancer-related Molecular Pathways
- Nuclear Structure and Function
- Medical Imaging Techniques and Applications
Ghent University Hospital
2020-2025
Cancer Research Institute Ghent
2023-2025
Princess Máxima Center
2024
Erasmus MC Cancer Institute
2024
University Medical Center Utrecht
2024
AZ Sint-Jan
2023
Ghent University
2023
Cancer Research Institute
2023
We report an exceptional case of a spindle cell mesenchymal tumor with S100 and CD34 co-reactivity, which harbored SLMAP::RAF1 fusion. To the best our knowledge, this is second co-reactivity specific Remarkable presence calcification heterotopic ossification in center lesion, feature that, to has not been described yet RAF1-rearranged tumors.
Ubiquitin-specific protease 6 ( USP6 ) rearrangements have been identified in aneurysmal bone cyst, nodular fasciitis, myositis ossificans, fibro-osseous pseudotumour of digits and cellular fibroma tendon sheath. These entities show clinical as well histological overlap, suggesting they are all clonal neoplastic belonging to the same biological spectrum referred ‘ -associated neoplasms’. They a characteristic gene fusion formed by juxtaposition coding sequences promoter regions several...
RB1 stands as the pioneering discovery in tumour-suppressor genes, marking a pivotal breakthrough comprehending cancer development. This overview delves into role of both health and disease, exploring its association with tumourigenesis various cancers distinct subset soft-tissue neoplasms. Additionally, we discuss application immunohistochemistry fluorescence situ hybridisation to detect alterations.
Abstract In recent years, it has become clear that artificial intelligence (AI) models can achieve high accuracy in specific pathology‐related tasks. An example is our deep‐learning model, designed to automatically detect serous tubal intraepithelial carcinoma (STIC), the precursor lesion high‐grade ovarian carcinoma, found fallopian tube. However, standalone performance of a model insufficient determine its value diagnostic setting. To evaluate impact use this on pathologists' performance,...
Due to the increased application of RNA-based next-generation sequencing techniques on bone and soft tissue round cell sarcomas new fusions are frequently found, thereby expanding molecular landscape these tumors. In this report, we describe discuss finding an undifferentiated sarcoma with a epithelioid phenotype harboring novel EWSR1-SSX2 fusion. Treatment tumor entity according Euro Ewing 2012 protocol led complete pathologic response.
PRRX1-rearranged mesenchymal tumours are a recently identified and rare subgroup of soft tissue neoplasms with distinct morphological features genetic alterations. This study aims to further investigate the immunohistochemical profile underlying alterations in these order get more insight on their biology unique tumours.Two new molecular confirmed cases were thoroughly studied stainings (RB1, CD34, ALK pan-TRK), fluorescence situ hybridisation (FISH) RB1/13q12 RNA-based next-generation...
Atypical spindle cell/pleomorphic lipomatous tumor (ASPLT) is a newly described adipocytic type, recently included as separate entity in the fifth edition of World Health Organization (WHO) classification soft tissue and bone tumors. Here, we describe case an ASPLT with striking pleomorphic hyalinizing angiectatic (PHAT)-like growth pattern discuss diagnostical clues, which led to diagnosis ASPLT. To our knowledge, PHAT-like has not yet been reported setting
Paired-like homeobox 2B (
Abstract We describe a 46‐year‐old patient with an IDH ‐wildtype diffusely infiltrating atypical teratoid/rhabdoid tumour (AT/RT), SHH‐1B molecular subtype. The unusual histology and subsequent diagnosis in adult will be discussed.
L-2-hydroxyglutaric aciduria (L-2-HGA) is a rare neurometabolic disorder characterized by accumulation of L2-hydroxyglutarate (L-2-HG) due to mutations in the