A5032204376- Crystallization and Solubility Studies
- Coccidia and coccidiosis research
- X-ray Diffraction in Crystallography
- Bioactive Compounds and Antitumor Agents
- Antimicrobial Peptides and Activities
- Cancer Cells and Metastasis
- Chemical Synthesis and Analysis
- Parasitic Infections and Diagnostics
- Synthesis and Biological Evaluation
- Helminth infection and control
- Cancer therapeutics and mechanisms
- Biopolymer Synthesis and Applications
- Trypanosoma species research and implications
- Crystallography and molecular interactions
- RNA Interference and Gene Delivery
- Veterinary medicine and infectious diseases
- Protist diversity and phylogeny
- Vitamin D Research Studies
- Antibiotic Resistance in Bacteria
- Medicinal Plant Pharmacodynamics Research
- Peptidase Inhibition and Analysis
- Cancer Risks and Factors
- Monoclonal and Polyclonal Antibodies Research
- Chemical Reactions and Isotopes
- Vitamin C and Antioxidants Research
Adam Mickiewicz University in Poznań
2016-2025
Université Paris Sciences et Lettres
2022
Inserm
2022
Institut Curie
2022
Centre National de la Recherche Scientifique
2022
Persister cancer cells represent rare populations of resistant to therapy. Cancer can exploit epithelial-mesenchymal plasticity adopt a drug-tolerant state that does not depend on genetic alterations. Small molecules interfere with cell or kill in state-dependent manner are highly sought after. Salinomycin has been shown the mesenchymal by sequestering iron lysosomes, taking advantage addiction this state. Here, we report chemo- and stereoselective synthesis series structurally complex small...
A series of 12 novel monosubstituted N-benzyl amides salinomycin (SAL) was synthesized for the first time and characterized by NMR FT-IR spectroscopic methods. Molecular structures three derivatives in solid state were determined using single crystal X-ray method. All compounds obtained screened their antiproliferative activity against various human cancer cell lines as well most problematic bacteria strains such methicillin-resistant Staphylococcus aureus (MRSA) epidermidis (MRSE),...
Polyether ionophore salinomycin (SAL) and its semi-synthetic derivatives are recognized as very promising anticancer drug candidates due to their activity against various types of cancer cells, including multidrug-resistant populations. Ovarian is the deadliest among gynecologic malignancies, which connected with development chemoresistant forms disease in over 70% patients after initial treatment regimen. Thus, we decided examine properties SAL selected a series drug-sensitive (A2780,...
Chemotherapy is one of the leading cancer treatments. Unfortunately, its use can contribute to several side effects, including gynotoxic effects in women. Ovarian reserve suppression and estrogen deficiency result reduced quality life for patients are frequently cause infertility early menopause. Classic alkylating cytostatics among most toxic chemotherapeutics this regard. They DNA damage ovarian follicles cells they contain, also induce oxidative stress or affect numerous signaling...