A5100699801- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Health disparities and outcomes
- Transcranial Magnetic Stimulation Studies
- Mental Health Research Topics
- Stroke Rehabilitation and Recovery
- EEG and Brain-Computer Interfaces
- Health, Environment, Cognitive Aging
- COVID-19 and Mental Health
- Neurobiology of Language and Bilingualism
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Aging and Gerontology Research
- Technology Use by Older Adults
- Aging, Health, and Disability
- Neural and Behavioral Psychology Studies
- Long-Term Effects of COVID-19
- Chronic Disease Management Strategies
- Heart Rate Variability and Autonomic Control
- Frailty in Older Adults
- Digital Mental Health Interventions
- Mind wandering and attention
- Cognitive Functions and Memory
- Cognitive Abilities and Testing
- Physical Activity and Health
- Pain Management and Placebo Effect
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2018-2025
Institut Guttmann
2018-2025
Universitat Autònoma de Barcelona
2018-2024
Universitat de Barcelona
2021-2023
Harvard University
2021-2023
Hebrew SeniorLife
2023
Hadassah Medical Center
2023
Departament de Salut
2021
Universidad Politécnica de Madrid
2011-2018
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2017
The Barcelona Brain Health Initiative (BBHI) is an ongoing prospective longitudinal study focused on identifying determinants of brain health. main objectives are: (i) to characterize lifestyle, cognitive, behavioral and environmental markers related a given individual's cognitive mental functions in middle old age, (ii) assess the biological predictive maintenance health, (iii) evaluate impact controlled multi-dimensional lifestyle intervention improving maintaining BBHI cohort consists...
Why education is linked to higher cognitive function in aging fiercely debated. Leading theories propose that reduces brain decline aging, enhances tolerance pathology, or it does not affect but rather reflects early-life function. To test these theories, we analyzed 407.356 episodic memory scores from 170.795 participants >50 years, alongside 15.157 MRIs 6.472 across 33 Western countries. More was associated with better memory, larger intracranial volume and slightly of memory-sensitive...
Background Evidence in older adults suggests that higher cardiorespiratory fitness and lower cardiovascular risk are associated with greater cognition. However, given changes the brain lead to cognitive decline begin decades before onset of symptoms, understanding mechanisms by which modifiable factors health midlife is critical can development strategies promote maintain as we age. Methods Results In 501 middle-aged (aged 40-65 years) adult participants BBHI (Barcelona Brain Health...
Abstract Aims Our study aimed to (1) identify trajectories on different mental health components during a two-year follow-up of the COVID-19 pandemic and contextualise them according periods; (2) investigate associations between several exposures, determine whether there were differences among outcomes regarding these associations. Methods We included 5535 healthy individuals, aged 40–65 years old, from Barcelona Brain Health Initiative (BBHI). Growth mixture models (GMM) fitted classify...
The COVID-19 pandemic puts health and care systems under pressure globally. This current paper highlights challenges arising in the for older vulnerable populations this context reflects upon possible perspectives different making use of nested integrated approaches adapted during work EU-funded project VIGOUR ("Evidence based Guidance to Scale-up Integrated Care Europe", funded by European Union's Health Programme 2014–2020 Grant Agreement Number 826640).
Abstract Background Disease-modifying agents to counteract cognitive impairment in older age remain elusive. Hence, identifying modifiable factors promoting resilience, as the capacity of brain maintain cognition and function with aging disease, is paramount. In Alzheimer’s disease (AD), education occupation are typical reserve proxies. However, importance psychological being increasingly recognized, their operating biological mechanisms elucidated. Purpose life (PiL), one pillars...
Why education is linked to higher cognitive function in aging fiercely debated. Leading theories propose that reduces brain decline aging, enhances tolerance pathology, or it does not affect but rather reflects early-life function. To test these theories, we analyzed 407.356 episodic memory scores from 170.795 participants > 50 years, alongside 15.157 MRIs 6.472 across 33 Western countries. More was associated with better memory, larger intracranial volume and slightly of memory-sensitive...
Brain atrophy is a key factor behind episodic memory loss in aging, but the nature and ubiquity of this relationship remains poorly understood. This study leveraged 13 longitudinal datasets, including 3,737 cognitively healthy adults (10,343 MRI scans; 13,460 assessments), to determine whether brain change-memory change associations are more pronounced with age genetic risk for Alzheimer's Disease. Both factors associated accelerated decline, yet it unclear exacerbated beyond what alone...
Abstract Objectives Bilingualism can stimulate brain plasticity and is often associated with better executive function. We investigated whether language usage was related to the volume of white matter lesions in a cohort middle-aged older adults different multilingual characteristics, including monolingualism daily life (use one language), bilingualism two languages) multilingualism (active use three languages, i.e., Catalan, Spanish, English). also explored cognitive status change over...
Abstract Differences in the volumes of brain structures between individuals are often linked to various conditions, including Alzheimer’s disease, schizophrenia, and overall health. However, it remains unclear what extent these differences reflect individual levels present at young adulthood or diverging aging trajectories later ages. In this study, we analyze dynamics volume six based on MRI scans from a large cross-cohort longitudinal sample cognitively healthy adults (n = 8,311 with...
In recent years, supported by new scientific evidence, the conceptualization of cognitive reserve (CR) has been progressively enriched and now encompasses not only stimulating activities or educational level, but also lifestyle activities, such as leisure physical activity socialization. this context, there is increasing interest in understanding role psychological factors brain health functioning. a previous study, we have found that these mediated relationship between CR self-reported...
Rey Auditory Verbal Learning Test (RAVLT) is an episodic memory helpful measure to detect changes associated with abnormal aging. There a lack of RAVLT validation and normalization studies in Spain. The aim was determine its psychometric properties explore long-term forgetting (LTF) performance through 1-week delayed recall under three different modes administration. administered 602 cognitively healthy volunteers, aged between 41 65 years, whom 251 completed the LTF assessment. Findings...
Physical activity has many health benefits for individuals with and without history of brain injury. Here we evaluated in a large cohort study the impact physical on global cognitive as measured by PROMIS NeuroQoL function questionnaires. A nested case control assessed influence traumatic injury (TBI) effects since underlying pathophysiology barriers to TBI may mean perceived outcomes differ compared general population. Those (n=81) had significantly lower Global (=-1.66, p=.010) (=-2.65,...
The Barcelona Brain Health Initiative is a longitudinal cohort study that began in 2017 and aims to understand characterize the determinants of brain health maintenance middle aged adults. A 4686 individuals between ages 40 65 years free from any neurological or psychiatric diseases was established, we collected extensive demographic, socio-economic information along with measures self-perceived lifestyles (general health, physical activity, cognitive socialization, sleep, nutrition vital...
Pain processing involves emotional and cognitive factors that can modify pain perception. Increasing evidence suggests catastrophizing (PC) is implicated, through pain-related self-thoughts, in the maladaptive plastic changes related to maintenance of chronic (CP). Functional magnetic resonance imaging (fMRI) studies have shown an association between CP two main networks: default mode (DMN) dorsoattentional (DAN). Brain system segregation degree (SyS), fMRI framework used quantify extent...
Abstract Objectives Cognitive dispersion, representing intraindividual fluctuations in cognitive performance, is associated with decline advanced age. We sought to elucidate sociodemographic, neuropsychological, and brain connectivity correlates of dispersion middle age, further consider potential influences the severity subjective complaints (SCC). Methods Five hundred twenty healthy volunteers from Barcelona Brain Health Initiative (aged 40–66 years; 49.6% females, 453 magnetic resonance...
Chronic pain is associated with worse mental health and cognitive impairment, which can be a cause or consequence of brain structure function alterations, e.g., maladaptive plasticity, antinociceptive system dysregulation. Cognitive reserve reflects the effectiveness internal connections it has been shown to protective factor in damage, slowing aging reducing risk disorders. The current study explored impact chronic on psychosocial factors, health, cognition. Furthermore, we aimed examine...
Brain health is essential to successful aging, and exercise brain health. Evidence supports the benefits of regular physical cognitive in preventing or delaying progressin mild impairment dementia. Despite known benefits, motivation initiate adhere an program can be challenging older adults. We propose that assessment adult population part individualized initial development ongoing precision coaching facilitate initiation of—and adherence to—individualized multi-modal programs sustained...
The COVID-19 pandemic provides a unique opportunity to investigate the psychological impact of global major adverse situation. Our aim was examine, in longitudinal prospective study, demographic, psychological, and neurobiological factors associated with interindividual differences resilience mental health pandemic.
In the face of demographic ageing European healthcare providers and policy makers are recognising an increasing prevalence frail, community-dwelling older adults, prone to adverse outcomes.Prefrailty, before onset functional decline, is suggested be reversible but interventions targeting this risk syndrome limited.No consensus on definition, diagnosis or management pre-frailty exists.The PERsonalised ICT Supported Service for Independent Living Active Ageing (PERSSILAA) project (2013-2016...
The prefrontal cortex (PFC) plays a crucial role in cognition, particularly executive functions. Cortical reactivity measured with Transcranial Magnetic Stimulation combined Electroencephalography (TMS-EEG) is altered pathological conditions, and it may also be marker of cognitive status middle-aged adults. In this study, we investigated the associations between measures TMS evoked EEG explored whether effects relationship were related to neurofilament light chain levels (NfL), neuroaxonal...
Introduction Understanding the impact of different lifestyle trajectories on health preservation and disease risk is crucial for effective interventions. Methods This study analyzed engagement over five years in 3,013 healthy adults aged 40-70 from Barcelona Brain Health Initiative using K-means clustering. Nine modifiable factors were considered, including cognitive, physical, social activity, vital plan, diet, obesity, smoking, alcohol consumption, sleep. Self-reported diagnoses new...