A5039062062- Osteoarthritis Treatment and Mechanisms
- Veterinary Equine Medical Research
- Hip disorders and treatments
- Neurological disorders and treatments
- Tendon Structure and Treatment
- Knee injuries and reconstruction techniques
- Veterinary Orthopedics and Neurology
- Periodontal Regeneration and Treatments
- Dermatologic Treatments and Research
- Orthopaedic implants and arthroplasty
- Wound Healing and Treatments
- Cell Adhesion Molecules Research
- Inflammatory mediators and NSAID effects
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Shoulder Injury and Treatment
- Neuroscience and Neuropharmacology Research
- Botulinum Toxin and Related Neurological Disorders
- Toxin Mechanisms and Immunotoxins
- Bone Metabolism and Diseases
- Invertebrate Taxonomy and Ecology
- Bone health and osteoporosis research
- Anesthesia and Sedative Agents
- Cardiac and Coronary Surgery Techniques
- Forensic Toxicology and Drug Analysis
Université de Montréal
2013-2024
Cegep de Saint Hyacinthe
2012-2024
British Veterinary Association
2023
Institut de Cancérologie de l'Ouest
2014
Paul Pascal Research Center
2014
Hôpital d'instruction des Armées Desgenettes
2009
Service de Santé des Armées
2006-2009
Université Joseph Fourier
2006
Inserm
2006
Université Paris-Sud
2006
Summary Reasons for performing study : The earliest osteochondrosis (OC) microscopic lesion reported in the literature was present femorotibial joint of a 2‐day‐old foal suggesting that OC lesions and factors initiating them may arise prior to birth. Objective To examine developing equine epiphysis detect histological changes could be precursors lesions. Methods Osteochondral samples from 21 fetuses 13 foals were harvested selected sites scapulohumeral, humeroradial, metacarpophalangeal,...
Focal ischemic chondronecrosis of epiphyseal growth cartilage (EGC) during endochondral ossification is believed to be a key early event on the pathway osteochondrosis (OC) in both animals and humans. The lateral ridge equine trochlea site where severe osteochondritis dissecans lesions frequently arise model for study naturally occurring disease. Non-invasive imaging investigate EGC vascularity may help elucidate why focal ischemia occurs. 3T MRI susceptibility-weighted (SWI) femoral OC...
ObjectiveTo characterize the initial events in cleavage of type II collagen mediated by cathepsin K and demonstrate presence resulting products human equine articular osteoarthritic cartilage.DesignEquine was digested with characterized mass spectrometry. Anti-neoepitope antibodies were raised against most N-terminal used to investigate progress cleavage, vitro, K-derived cartilage.ResultsSix sites distributed throughout triple helical region identified collagen. Most cleavages occurred...
Objective To assess the effects of an intra‐articular ( IA ) lidocaine or bupivacaine injection on synovial fluid SF biomarkers cartilage metabolism. Study Design Experimental. Animals Horses (n = 6). Methods The study had 2 components, each with identical design: first arm assessed (0.5%) in intercarpal joints and, after a 2‐week washout period, second was conducted to evaluate (2%) tarsocrural joints. mares were randomly assigned receive test local anesthetic target joint placebo (0.9%...
Rationale: Hypoxia-induced pulmonary hypertension involves hypoxia-inducible factor-1α (HIF-1α) activation as well elevated resting calcium levels. Cyclosporin A (CsA) inhibits calcium-induced calcineurin and blocks the stabilization of HIF-1α in cultured cells.Objectives: We hypothesized that treatment rats with CsA would prevent HIF-1–dependent gene transcription, lower specific responses to acute hypoxia, right ventricle hypertrophy resulting from prolonged exposure hypoxia.Methods: Acute...
Abstract We report Polarization-resolved Second Harmonic Generation (P-SHG) and directional SHG (forward backward, F/B) measurements of equine foetal adult collagen in meniscus, over large field-of-views using sample-scanning. Large differences structure fibril orientation with maturation are revealed, validating the potential for this novel methodology to track such changes meniscal structure. The menisci had a non-organized more random fibrillar when compared P-SHG. For latter, clusters...
High cyclic strains induce formation of microcracks in bone, triggering targeted bone remodeling, which entails osteoclastic resorption. Racehorse is an ideal model for studying the effects high-intensity loading, as it subject to focal and subsequent The volume resorption vitro considered a direct indicator osteoclast activity but indirect 2D measurements are used more often. Our objective was develop accurate, high-throughput method quantify equine μCT 3D images. Here, osteoclasts were...
Steaming hay significantly reduces respirable particles and provides a palatable alternative to dry for horses with asthma, but there are few prospective studies demonstrating the clinical efficacy of steamed hay.
In the present study, we tested hypothesis that chronic ANG I-converting enzyme (ACE) inhibition could improve training-induced improvement in endurance exercise performance and this be related to enhanced skeletal muscle metabolic efficiency. Female Wistar rats were assigned four groups comprising animals either maintained sedentary or trained (Sed Tr, respectively), treated not for 10 wk with an ACE inhibitor, perindopril (2 mg.kg(-1).day(-1)) (Per Ct, respectively) (n = 8 each). Trained...
There is limited information available concerning normal equine meniscal morphology, its degeneration and role in osteoarthritis (OA).To characterise morphology lesions to explore the relationship between femorotibial OA.Ex vivo cadaveric study.Menisci were harvested from 7 joints (n = 14 menisci) 15 with OA 30 menisci). A macroscopic score (cartilage osteophytosis) was employed measure disease severity each compartment. The femoral tibial surfaces scored for fibrillation tears (1-4)....
Abstract Objective —To evaluate the effects of continuous oral administration phenylbutazone on serum and synovial fluid biomarkers skeletal matrix metabolism in horses. Animals —11 adult female horses without clinical or radiographic evidence joint disease. Procedures —Horses were randomly assigned to control treatment groups. Phenylbutazone was administered orally twice daily at a dose 4.4 mg/kg for 3 days group subsequently 2.2 7 days. Serum radiocarpal samples obtained baseline...
Abstract Background The administration of bisphosphonate medications, which target osteoclastic‐bone remodelling, to juvenile and adult racehorses is a matter debate owing concerns that these molecules remain bound the bone‐mineralised matrix may interfere with subsequent bone growth, adaptation exercise healing microdamage in equine athletes. Osteoclasts participate endochondral ossification, subchondral remodelling repair. There knowledge gap on role osteoclast biology growth maturation...
The expression of type X collagen (COL X), a late-stage chondrocyte hypertrophy marker in human mesenchymal stem cells (MSCs) from osteoarthritis (OA) patients poses major setback to current cartilage and intervertebral disc tissue engineering efforts. However, it is not yet clear whether COL expressed by all bone marrow or if related age, gender, site, disease status, drug therapy. In the study, we report that upregulated MSCs rabbits surgical instability model OA (anterior cruciate...
Osteochondrosis is an ischemic chondronecrosis of epiphyseal growth cartilage that results in focal failure endochondral ossification and osteochondritis dissecans at specific sites the epiphyses humans animals, including horses. The upstream events leading to ischemia remain unknown. matrix composed proteoglycan collagen macromolecules encases its vascular tree canals. undergoes major dynamic changes early life could weaken it biomechanically predispose trauma failure. Subregions neonatal...