A5031916471- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Lysosomal Storage Disorders Research
- RNA Research and Splicing
- Carbohydrate Chemistry and Synthesis
- Calcium signaling and nucleotide metabolism
- Cell Image Analysis Techniques
- Marine and coastal plant biology
- Autoimmune and Inflammatory Disorders Research
- Coral and Marine Ecosystems Studies
- thermodynamics and calorimetric analyses
- Ion channel regulation and function
- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Marine Biology and Ecology Research
- Infant Nutrition and Health
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
Emory University
2022-2025
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2018-2020
National Institutes of Health
2018-2020
California State University, Long Beach
2017
A hallmark of Niemann-Pick disease, type C (NPC) is the progressive degeneration Purkinje neurons in cerebellum caused by accumulation free cholesterol and glycosphingolipids lysosome. Recent studies suggest that state glycosylation lysosomal membrane proteins may play a role disease progression. Our study has identified presence highly glycosylated form Lysosome Associated Membrane Protein 1 (LAMP1) correlated spatiotemporally with neuron loss. This LAMP1 was predominantly localized to...
Abstract Astropectinid seastars typically develop as either feeding bipinnaria larvae or nonfeeding, barrel‐shaped larvae. Understanding the direction and frequency of evolutionary transitions between these larval nutritional modes requires knowledge distribution developmental diversity in family, but development only a few astropectinids is known. Here we describe embryogenesis, development, metamorphosis Astropecten armatus , an astropectinid common soft‐sediment subtidal habitats southern...
Abstract Cell state plasticity is retained by all stem-like and differentiated cells within glioblastoma (GBM) tumors. GBM can exploit these state-shifting capacities to evade resist therapeutics. Thus, there a need identify target the regulators of cell transitions. To address this question, we use fully human platform where hiSPC-derived organoids serve as recipient environment host engrafted directly from surgically resected GBMs. This allows us precisely examine how microenvironmental...
Abstract Background Kv1.3 channels are promising therapeutic targets to modulate neuroinflammatory responses in neurodegenerative disease including Alzheimer’s (AD). Although the ability of blockers reduce neuropathology AD mouse models has been demonstrated, cellular mechanisms remain unclear. Method 5xFAD mice aged 6 months were treated with PAP‐1 (a small molecule blocker, chow), ShK‐223 (peptide intra‐peritoneal twice‐weekly), control chow, or vehicle injections until 9 age. We assessed...
SUMMARY Extrinsic signaling between diverse cell types is crucial to nervous system development. Ligand binding a key driver of developmental processes, but it remains significant challenge disentangle how collections these signals act cooperatively affect changes in recipient cells. In the developing human brain, cortical progenitors transition from neurogenesis gliogenesis stereotyped progression that influenced by extrinsic ligands. Therefore, we sought use wealth published genomic data...
Extrinsic signaling between diverse cell types is crucial to nervous system development. Ligand binding a key driver of developmental processes, but it remains significant challenge disentangle how collections these signals act cooperatively affect changes in recipient cells. In the developing human brain, cortical progenitors transition from neurogenesis gliogenesis stereotyped progression that influenced by extrinsic ligands. Therefore, we sought use wealth published genomic data brain...