A5076718530- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Bone fractures and treatments
- Spaceflight effects on biology
- Cellular Mechanics and Interactions
- Effects of Vibration on Health
- Muscle Physiology and Disorders
- Bone health and treatments
- Adipose Tissue and Metabolism
- Osteoarthritis Treatment and Mechanisms
- Orthopaedic implants and arthroplasty
- Musculoskeletal pain and rehabilitation
- Genetics and Physical Performance
- Electromagnetic Fields and Biological Effects
- Bone and Joint Diseases
- Cerebral Palsy and Movement Disorders
- Elasticity and Material Modeling
- Mesenchymal stem cell research
- Exercise and Physiological Responses
- Scoliosis diagnosis and treatment
- Veterinary Equine Medical Research
- Spine and Intervertebral Disc Pathology
- Morphological variations and asymmetry
- Body Composition Measurement Techniques
- Adipokines, Inflammation, and Metabolic Diseases
Stony Brook University
2016-2025
State University of New York
2012-2024
Stony Brook School
2023-2024
Unité de Nutrition Humaine
2023
Mayo Clinic
2001
Rubin
2001
Stony Brook Medicine
1997
North Shore University Hospital
1997
University of Oregon
1997
New York University
1997
In studies on a functionally isolated avian-bone preparation to which external loads could be applied in vivo, we determined the following information. Removal of load-bearing resulted substantial remodeling endosteally, intracortically, and, lesser extent, periosteally. Since balance this was negative, bone mass declined. It therefore appears that functional prevents process would otherwise lead disuse osteoporosis. Four consecutive cycles day an externally loading regimen engendered...
Abstract A 1-year prospective, randomized, double-blind, and placebo-controlled trial of 70 postmenopausal women demonstrated that brief periods (<20 minutes) a low-level (0.2g, 30 Hz) vibration applied during quiet standing can effectively inhibit bone loss in the spine femur, with efficacy increasing significantly greater compliance, particularly those subjects lower body mass. Introduction: Indicative anabolic potential mechanical stimuli, animal models have short (<30...
Abstract The capacity for functional adaptation within the skeleton was studied using functionally isolated turkey ulna preparation. results of this study would suggest that adaptive bone remodeling is extremely sensitive to alterations in both magnitude and distribution strain generated tissue. At present, it appears a loading regime can only influence when dynamic nature. full osteogenic potential its then achieved after an short exposure stimulus. potency stimulus be proportional...
ABSTRACT Rosette strain gauges were attached to the midshaft of radius and tibia two horses dogs, which ran on a treadmill through their entire range speed gait. The relative magnitudes principal strains opposite cortices each bone remained constant stance phase stride, orientation varied by maximum only 14° range. rate increased linearly with speed, but peak magnitude was also dependent upon gait used, increasing incrementally up 59% at transition from walk trot, dropping 42 % trot canter....
Abstract The osteogenic potential of short durations low-level mechanical stimuli was examined in children with disabling conditions. mean change tibia vTBMD +6.3% the intervention group compared −11.9% control group. This pilot randomized controlled trial provides preliminary evidence that represent a noninvasive, non-pharmacological treatment low BMD Introduction: Recent animal studies have demonstrated anabolic low-magnitude, high-frequency to trabecular bone weight-bearing regions...
The potential for brief periods of low-magnitude, high-frequency mechanical signals to enhance the musculoskeletal system was evaluated in young women with low BMD. Twelve months this noninvasive signal, induced as whole body vibration at least 2 minutes each day, increased bone and muscle mass axial skeleton lower extremities compared controls.The incidence osteoporosis, a disease that manifests elderly, may be reduced by increasing peak young. Preliminary data indicate extremely low-level...
Abstract The skeleton's sensitivity to mechanical stimuli represents a critical determinant of bone mass and morphology. We have proposed that the extremely low level (<10 microstrain), high frequency (20-50 Hz) strains, continually present during even subtle activities such as standing are important defining skeleton larger strains typically associated with vigorous activity (>2000 microstrain). If these low-level indeed anabolic, then this could serve basis for...
It is generally believed that mechanical signals must be large in order to anabolic bone tissue. Recent evidence indicates, however, extremely low-magnitude (<10 microstrain) readily stimulate formation if induced at a high frequency. We examined the ability of low-magnitude, high-frequency restore cell activity inhibited by disuse. Adult female rats were randomly assigned six groups: baseline control, age-matched mechanically stimulated for 10 min/day, disuse (hind limb suspension),...
The ability of exercise to decrease fat mass and increase bone may occur through mechanical biasing mesenchymal stem cells (MSCs) away from adipogenesis toward osteoblastogenesis. C3H10T1/2 MSCs cultured in highly adipogenic medium express peroxisome proliferator-activated receptor gamma adiponectin mRNA protein, accumulate intracellular lipid. Mechanical strain applied for 6 h daily inhibited expression by up 35 50%, respectively, after 5 d. A active total beta-catenin levels during...
Obesity, a global pandemic that debilitates millions of people and burdens society with tens billions dollars in health care costs, is deterred by exercise. Although it presumed the more strenuous physical challenge effective will be suppression adiposity, here shown 15 weeks brief, daily exposure to high-frequency mechanical signals, induced at magnitude well below which would arise during walking, inhibited adipogenesis 27% C57BL/6J mice. The signal also reduced key risk factors onset type...
Mesenchymal stem cells (MSCs) are defined by their ability to self-renew and differentiate into the that form mesodermal tissues such as bone fat. Low magnitude mechanical signals (LMMS) have been shown be anabolic recently reported suppress development of fat in normal animals fed a regular diet. Using male C57BL/6J mice, LMMS (0.2g, 90-Hz signal applied for 15 min/d, 5 d/wk) simultaneously promote formation prevent diet-induced obesity was correlated influences on molecular environment...
The healing of skeletal fractures is essentially a replay bone development, involving the closely regulated, interdependent processes chondrogenesis and osteogenesis. Using rat femur model to determine degree transcriptional complexity these processes, suppressive subtractive hybridization (SSH) was performed between RNA isolated from intact that callus post-fracture (PF) days 3, 5, 7, 10 as means identifying up-regulated genes in regenerative process. Analysis 3,635 cDNA clones revealed 588...