A5080683552- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Epilepsy research and treatment
- Advanced Neuroimaging Techniques and Applications
- EEG and Brain-Computer Interfaces
- Anesthesia and Neurotoxicity Research
- Optical Imaging and Spectroscopy Techniques
- Neural dynamics and brain function
- Diet and metabolism studies
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
University of Southern California
2024
Sichuan University
2022-2024
Southern California University for Professional Studies
2024
West China Hospital of Sichuan University
2022-2024
Abstract A major challenge for human neuroimaging using functional MRI is the differentiation of neuronal excitation and inhibition which may induce positive negative BOLD responses. Here we present an innovative multi-contrast laminar technique that offers comprehensive quantitative imaging neurovascular (CBF, CBV, BOLD) metabolic (CMRO2) responses across cortical layers at 7 Tesla. This was first validated through a finger-tapping experiment, revealing 'double-peak' activation patterns...
Abstract Postictal generalized electroencephalographic suppression is a possible marker for sudden unexpected death in epilepsy. We aimed to investigate the cortical surface area abnormalities epilepsy patients with postictal suppression. retrospectively included 30 (PGES+), 21 without (PGES−), and healthy controls. Surface-based analysis on high-resolution T1-weighted images was conducted areas were compared among three groups, alongside correlation analyses seizure-related clinical...
A major challenge for human neuroimaging using functional MRI is the differentiation of neuronal excitation and inhibition which may induce positive negative BOLD responses. Here we present an innovative multi-contrast laminar technique that offers comprehensive quantitative imaging neurovascular (CBF, CBV, BOLD) metabolic (CMRO
We proposed a 7T laminar concurrent ASL, VASO and BOLD fMRI sequence to obtain quantitative CBF, CBV, T2-BOLD CMRO2 measurements with high resolution specificity detect layer-dependent vascular metabolic activities. Ipsilateral visual stimuli (eccentricity of 4°–6°) induced ring-shaped CBF signal increase on cortical surface corresponding the pattern stimulus while decreased BOLD/CBF signals can be seen in adjacent fovea regions. In negative response (NBR) regions, moderate decrease CBV...
Motivation: To better understand the complex interplay between neurovascular responses and metabolism. Goal(s): The goal was to develop a multi-contrast laminar fMRI tool concurrently measure CBF, CBV, BOLD, CMRO2 signals. Approach: We employed novel pulse sequence simultaneously acquire ASL VASO T2-BOLD signals at high spatial resolution of 7T. also incorporated calibrated approach (Davis model) calculate CMRO2, using parameters estimated from breath-hold induced hypercapnia. Results: found...