A5069268372- Genetic Associations and Epidemiology
- Advanced Causal Inference Techniques
- Climate Change and Health Impacts
- Geometric Analysis and Curvature Flows
- Geometry and complex manifolds
- Bioinformatics and Genomic Networks
- Air Quality and Health Impacts
- Folate and B Vitamins Research
- Urban Green Space and Health
- Infant Health and Development
- Metabolism, Diabetes, and Cancer
- Advanced Differential Geometry Research
- Cardiac electrophysiology and arrhythmias
- Neonatal and fetal brain pathology
- COVID-19 and Mental Health
- Intraocular Surgery and Lenses
- Nonlinear Partial Differential Equations
- Genetic and phenotypic traits in livestock
- Gene expression and cancer classification
- Land Use and Ecosystem Services
- Genomics and Rare Diseases
- Urban Heat Island Mitigation
- Schizophrenia research and treatment
- Retinopathy of Prematurity Studies
- Long-Term Effects of COVID-19
University of Toronto
2020-2024
Public Health Ontario
2020-2023
3M (United States)
2020-2021
Rationale Evidence for the association between fine particulate matter (PM 2.5 ) and mortality among patients with tuberculosis (TB) is limited. Whether greenness protects air pollution-related multidrug-resistant (MDR-TB) completely unknown. Methods 2305 reported in Zhejiang Ningxia were followed up from MDR-TB diagnosis until death, loss to follow-up or end of study (31 December 2019), an average 1724 days per patient. 16-day averages contemporaneous Normalised Difference Vegetation Index...
Abstract Functional annotations have the potential to increase power of genome-wide association studies (GWAS) by prioritizing variants according their biological function, but this has not been well studied. We comprehensively evaluated all 1132 traits in UK Biobank whose SNP-heritability estimates were given “medium” or “high” labels Neale’s lab. For each trait, we integrated GWAS summary statistics close 8 million common (minor allele frequency $$>1\%$$ <mml:math...
Abstract Within population biobanks, genetic discovery for specialized phenotypes is often limited by incomplete ascertainment. Machine learning (ML) increasingly used to impute missing from surrogate information. However, imputing can invalidate statistical inference when the imputation model misspecified, and proxy analysis of ML-phenotype introduce spurious associations. To overcome these limitations, we SynSurr, an approach that jointly analyzes a partially target phenotype with...
Abstract Background and Hypothesis Schizophrenia is associated with substantial physical psychiatric comorbidities that increase the risk of severe outcomes in COVID-19 infection. However, few studies have examined differences care among people schizophrenia throughout pandemic. We hypothesized rates in-hospital mortality, admission to intensive unit (ICU), length stay differed without schizophrenia. Study Design conducted a population-based retrospective cohort study using administrative...
Abstract Functional annotations have the potential to increase power of genome-wide association studies (GWAS) by prioritizing variants according their biological function. Focusing on variant-specific annotation meta-scores including CADD (Kircher et al., 2014) and Eigen (Ionita-laza 2016), we broadly examined GWAS summary statistics 1,132 traits from UK Biobank (Sudlow 2015) using weighted p-value approach (Genovese 2006) stratified false discovery control (sFDR) method (Sun 2006). These...
Objective To investigate the effects of metformin on endothelium function and insulin resistance in patients with hypertension. Methods Eighty-three hypertension were randomly divided into control group group(metformin 0.25 g, bid). Each treated antihypertensive therapy. Blood pressure, blood biochemistry,fasting glucose,fasting FMD measured before after 8 days 90 treatment. Results HOMA-IR improved three months treatment from(4.25±1.75)to(2.01±0.85), from(5.30±2.09)to(8.68±2.35). There was...
Abstract Functional annotations have the potential to increase power of genome-wide association studies (GWAS) by prioritizing variants according their biological function, but this has not been well studied. We comprehensively evaluated all 1,132 traits in UK Biobank whose SNP-heritability estimates were given "medium" or "high" labels Neale’s lab. For each trait, we integrated GWAS summary statistics close 8 million common (minor allele frequency > 1%) with either 75 individual...