A5065911464- Lysosomal Storage Disorders Research
- Neural Networks and Applications
- Nonlinear Dynamics and Pattern Formation
- Carbohydrate Chemistry and Synthesis
- RNA and protein synthesis mechanisms
- Neurogenetic and Muscular Disorders Research
- Digital Mental Health Interventions
- Advanced biosensing and bioanalysis techniques
- Glycosylation and Glycoproteins Research
- Neural dynamics and brain function
- Neurogenesis and neuroplasticity mechanisms
- Immune Cell Function and Interaction
- Glycogen Storage Diseases and Myoclonus
- Autophagy in Disease and Therapy
- Ecology, Conservation, and Geographical Studies
- Ionic liquids properties and applications
- Child Nutrition and Feeding Issues
- Eosinophilic Esophagitis
- Parkinson's Disease Mechanisms and Treatments
- Calcium signaling and nucleotide metabolism
- Acute Lymphoblastic Leukemia research
- Cytomegalovirus and herpesvirus research
- Infant Nutrition and Health
- Environmental Conservation and Management
- Cerebral Palsy and Movement Disorders
Universitätsklinikum Erlangen
2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2025
Universitat de Barcelona
2023
University of Rostock
2016-2021
University of Potsdam
2018-2019
Leipzig University
2011-2014
SELEX is an iterative process in which highly diverse synthetic nucleic acid libraries are selected over many rounds to finally identify aptamers with desired properties. However, little understood as how binders enriched during the selection course. Next-generation sequencing offers opportunity open black box and observe a large part of population dynamics process.We have performed semi-automated procedure on model target streptavidin starting DNA oligonucleotide library compared results...
Abstract Cre-recombinase inducible model systems are extensively used in cancer research to manipulate gene expression specific tissues and induce autochthonous tumor growth. These often involve the cross-breeding of genetically engineered organisms containing loxP -flanked alleles with those expressing Cre-recombinase. This approach, while effective, has challenge requiring high numbers animals due breeding requirements. Other frequently induction methods direct application viral vectors....
We present an alternative approach to finite-size effects around the synchronization transition in standard Kuramoto model. Our main focus lies on conditions under which a collective oscillatory mode is well defined. For this purpose, minimal value of amplitude complex order parameter appears as proper indicator. The dependence minimum coupling strength varies due sampling variations and correlates with sample kurtosis natural frequency distribution. skewness determines resulting mode. hold...
Niemann-Pick disease Type C1 (NPC1) is a rare progressive neurodegenerative disorder caused by mutations in the NPC1 gene. The pathological mechanisms, underlying are not yet completely understood. Especially contribution of glial cells and gliosis to progression NPC1, controversially discussed. As an analysis affected unfeasible NPC1-patients, we recently developed vitro model system, based on derived from NPC1-patient specific iPSCs. Here, asked if this system recapitulates gliosis,...
Data presented in this article demonstrate the generation and characterization of two novel Niemann-Pick disease Type C1 (NPC1) patient-specific induced pluripotent stem cell (iPSC) lines, related to research Trilck et al. (Diversity Glycosphingolipid GM2 Cholesterol Accumulation NPC1 Patient-Specific iPSC-Derived Neurons; Brain Res.; 2017; 1657:52-61. doi: 10.1016/j.brainres.2016.11.031). For reprogramming fibroblasts, carrying homozygous mutation c.1180T>C prevalent c.3182T>C, were used....
Niemann-Pick disease Type C1 (NPC1) is a rare hereditary neurodegenerative disease. NPC1-patients suffer, amongst others, from ataxia, based on loss of cerebellar Purkinje cells (PCs). Impaired expression/function excitatory amino acid transporters (EAATs) are suspected contributing to PC-degeneration in spinocerebellar ataxias (SCAs). Thus, we studied EAAT-expression and its impact PC-activity NPC1-/-mice. Western blot revealed reduced EAAT1, EAAT2, EAAT4, βIII-spectrin levels EAATs play...
Supercritical Kuramoto oscillators with distributed frequencies can be separated into two disjoint groups: an ordered one locked to the mean field, and a disordered consisting of effectively decoupled oscillators-at least so in thermodynamic limit. In finite ensembles, contrast, such clear separation fails: The field fluctuates due finite-size effects thereby induces order group. This publication demonstrates this effect, similar noise-induced synchronization, purely deterministic system. We...
Niemann-Pick disease Type C (NPC) is a rare progressive neurodegenerative disorder with an incidence of 1:120,000 caused by mutations in the NPC1 or NPC2 gene. Only 5% NPC patients suffer from Here we demonstrate generation C2 (NPC2) patient-derived induced pluripotent stem cell line. This line capable to differentiate into derivatives neuronal lineage, providing valuable tool study pathogenic mechanisms NPC2.
Niemann-Pick type C2 (NP-C2) disease is a rare hereditary caused by mutations in the NPC2 gene. small, soluble protein consisting of 151 amino acids, primarily expressed late endosomes and lysosomes (LE/LY). Together with NPC1, transmembrane found these organelles, accomplishes exclusion cholesterol; thus, both proteins are essential to maintain cellular cholesterol homeostasis. Consequently, or NPC1 gene result pathophysiological accumulation sphingolipids LE/LY. The vast majority C...
Synchronisation – die Annaherung der Rhythmen gekoppelter selbst oszillierender Systeme ist ein faszinierendes dynamisches Phanomen, das in vielen biologischen, sozialen und technischen Systemen auftritt. Die vorliegende Arbeit befasst sich mit endlichen Ensembles schwach selbst-erhaltender Oszillatoren unterschiedlichen naturlichen Frequenzen. Das Standardmodell fur dieses kollektive Phanomen Kuramoto-Modell unter anderem aufgrund seiner Losbarkeit im thermodynamischen Limes unendlich...