A5021153084- Cancer-related gene regulation
- RNA modifications and cancer
- Wnt/β-catenin signaling in development and cancer
- Chemical synthesis and alkaloids
- Berberine and alkaloids research
- Fibroblast Growth Factor Research
- Chronic Myeloid Leukemia Treatments
- Kruppel-like factors research
- Epigenetics and DNA Methylation
- Cholinesterase and Neurodegenerative Diseases
- Helicobacter pylori-related gastroenterology studies
- Esophageal Cancer Research and Treatment
- Eosinophilic Esophagitis
- Ubiquitin and proteasome pathways
- Genomics and Chromatin Dynamics
- Bioactive natural compounds
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Microbial Natural Products and Biosynthesis
- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Ion Channels and Receptors
- Cytokine Signaling Pathways and Interactions
- Invertebrate Immune Response Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Xi'an Jiaotong University
2022-2025
Institute of Genetics and Developmental Biology
2022-2025
Southwest University
2019-2024
State Key Laboratory of Silkworm Genomic Biology
2019-2024
Ministry of Agriculture and Rural Affairs
2020
Abstract Background Lycorine hydrochloride (LH), an alkaloid extracted from the bulb of Lycoris radiata , is considered to have anti-viral, anti-malarial, and anti-tumorous effects. At present, underlying mechanisms LH in gastric cancer remain unclear. MCL1, anti-apoptotic protein BCL2 family, closely related drug resistance tumor. Therefore, MCL1 as a potential target for treatment. Methods The effect on was assessed vitro (by MTT, BrdU, western blotting…) vivo immunohistochemistry)....
Stomach adenocarcinoma (STAD) is a leading cause of cancer deaths, and the outcome patients remains dismal for lack effective biomarkers early detection. Recent studies have elucidated landscape genomic alterations gastric reveal some advanced-stage cancer, however, information about early-stage limited. Here, we adopt Weighted Gene Co-expression Network Analysis (WGCNA) to screen potential STAD using RNA-Seq clinical data from TCGA database. We find six gene clusters (or modules) are...
The ZBTB (zinc finger and BTB domain-containing) protein family comprises a significant class of transcription factors that interact with various corepressors histone/protein-modifying enzymes. This interaction facilitates chromatin remodeling the regulation gene silencing or activation, thereby playing crucial role in cancer progression. However, biological effects molecular mechanisms ZBTB6, member family, remain unclear. expression levels ZBTB6 breast (BC) were investigated through public...
Abstract With short survival time, glioblastoma (GBM) is the most malignant tumor in central nervous system. Recently, epigenetic enzymes play essential roles regulation of tumorigenesis and cancer development GBM. However, little known about MYST1/KAT8/MOF, a histone acetylation enzyme, The present study shows that MYST1 promotes GBM progression through activating epidermal growth factor receptor (EGFR) signaling. expression was increased negatively correlated with prognosis patients glioma...
Dihydrocapsaicin (DHC) is one of the main components capsaicinoids in Capsicum. It has been reported that DHC exerts anti-cancer effects on diverse malignant tumors, such as colorectal cancer, breast and glioma. However, studies focused effect upon melanoma have rarely done. In present study, A375 MV3 cell lines were treated with proliferation, migration, invasion significantly suppressed. Furthermore, effectively inhibited xenograft tumor growth pulmonary metastasis cells NOD/SCID mice...
Abstract Background: Lycorine hydrochloride (LH), an alkaloid extracted from the bulb of Lycoris radiata , is considered to have anti-viral, anti-malarial, and anti-tumorous effects. At present, underlying mechanisms LH in gastric cancer remain unclear. MCL1, anti-apoptotic protein BCL2 family, closely related drug resistance tumor. Therefore, MCL1 as a potential target for treatment. Methods: The effect on was assessed vitro (by MTT, BrdU, western blotting…) vivo immunohistochemistry)....
Abstract Specificity protein 4 transcription factor (SP4), a member of the Sp/Krüppel-like family (KLF), could bind to GT and GC box promoters, plays an essential role in transcriptional activating. Despite SP4 having been detected be highly expressed variety human tumors, its biological effect underlying molecular mechanism esophageal squamous cell carcinoma (ESCC) remains unclear. Our research discovered that high expression is primary ESCC specimens lines strongly associated with tumor...
<p>SP4 are closely associated with cancer cell apoptosis.</p>
<p>A major effect of SP4-PHF14 on Wnt3a and β-Catenin (CTNNB1).</p>
<div>Abstract<p>Specificity protein 4 transcription factor (SP4), a member of the Sp/Krüppel-like family (KLF), could bind to GT and GC box promoters, plays an essential role in transcriptional activating. Despite <i>SP4</i> having been detected be highly expressed variety human tumors, its biological effect underlying molecular mechanism esophageal squamous cell carcinoma (ESCC) remains unclear. Our research discovered that high SP4 expression is primary ESCC...
<div>Abstract<p>Specificity protein 4 transcription factor (SP4), a member of the Sp/Krüppel-like family (KLF), could bind to GT and GC box promoters, plays an essential role in transcriptional activating. Despite <i>SP4</i> having been detected be highly expressed variety human tumors, its biological effect underlying molecular mechanism esophageal squamous cell carcinoma (ESCC) remains unclear. Our research discovered that high SP4 expression is primary ESCC...
<p>High expression of PHF14 occurred in ESCC and is associated with the clinicopathologic feature.</p>
<p>A major effect of SP4-PHF14 on Wnt3a and β-Catenin (CTNNB1).</p>
<p>Co-knockdown of both SP4 and PHF14 also results in more decreased mRNA protein levels the Wnt3a β-Catenin.</p>
<p>Proposed model for the roles of SP4 on ESCC proliferation.</p>
<p>High expression of PHF14 occurred in ESCC and is associated with the clinicopathologic feature.</p>
<p>Proposed model for the roles of SP4 on ESCC proliferation.</p>
<p>Co-knockdown of both SP4 and PHF14 also results in more decreased mRNA protein levels the Wnt3a β-Catenin.</p>