A5081887190- Reconstructive Surgery and Microvascular Techniques
- Breast Implant and Reconstruction
- Organ and Tissue Transplantation Research
- Reconstructive Facial Surgery Techniques
- Wound Healing and Treatments
- Head and Neck Surgical Oncology
- Head and Neck Cancer Studies
- Tissue Engineering and Regenerative Medicine
- Dermatologic Treatments and Research
- Organ Donation and Transplantation
- Body Image and Dysmorphia Studies
- Body Contouring and Surgery
- Tracheal and airway disorders
- Xenotransplantation and immune response
- Nonmelanoma Skin Cancer Studies
- Facial Nerve Paralysis Treatment and Research
- Orthopedic Surgery and Rehabilitation
- Parathyroid Disorders and Treatments
- Biomedical Ethics and Regulation
- Cell Adhesion Molecules Research
- Antifungal resistance and susceptibility
- Foot and Ankle Surgery
- Autoimmune Bullous Skin Diseases
- Cancer Diagnosis and Treatment
- Surgical Sutures and Adhesives
Innsbruck Medical University
2015-2025
Universität Innsbruck
2015-2025
University Hospital Innsbruck
2014-2024
Center For Reconstructive Urethral Surgery
2006-2015
Universitätsklinik für Chirurgie Wien
2015
Aesthetic Surgery Center
2014
Klinik und Poliklinik für Mund-, Kiefer- und Plastische Gesichtschirurgie
2006
Deutsches Herzzentrum der Charité
1977
Universitätsmedizin Göttingen
1968
<i>Background:</i> An increasing number of soft tissue fillers have been introduced to the beauty market and these filler substances are widely used as non-toxic, non-immunogenic relatively harmless injectable alternatives surgical rejuvenation. Generally, facial – or surgically insertable products that fill up volume loss in aging face. Depending on bioavailability, chemical composition degradation, can be classified temporary permanent, organic inorganic autologous...
Rabensteiner, E MD; Wolfram, D; Backovic, A; Böck, G; Mayer, C; Parson, W; Huss, H; Piza-Katzer, Wick, G Author Information
Excessive fibrous capsule formation around silicone mammary implants (SMI) involves immune reactions to silicone. Capsular fibrosis, a common SMI complication linked host responses, worsens with specific implant topographies. Our study 10 patients investigated intra- and inter-individually, reduced surface roughness effects on disease progression, wound chronic inflammation, capsular composition. The results illuminate the significant impact of acute inflammatory fibrinogen accumulation,...
The authors investigated the immunological mechanisms underlying extensive peri-silicone implant capsule formation, one of most frequent postoperative complications in patients receiving silicone mammary implants.The studied immune response activation by phenotypic and functional characterization lymphocytes accumulated within this tissue. Intracapsular lymphoid cells autologous peripheral blood mononuclear were isolated analyzed flow cytometry. proportion T regulatory (CD4+ CD25(high)...
The most common complication of silicone breast implants is capsular contracture (massive scar formation around the implant). We postulate that always a sequel to inflammatory processes, with both innate and adaptive immune mechanisms participating. In general, fibroblasts macrophages have been used as cell types evaluate in vitro biocompatibility implant surfaces. Moreover, also T cells found at site initial stage fibrous capsule formation. However, only few studies addressed influence...
The etiology of exaggerated fibrous capsule formation around silicone mammary implants (SMI) is multifactorial but primarily induced by immune mechanisms towards the foreign material silicone. aim this work was to understand disease progression from implant insertion and immediate tissue damage response reflected in (a) acute wound proteome (b) adsorption chronic inflammatory proteins at surfaces. An intraindividual relative quantitation TMT-liquid chromatography-tandem mass spectrometry...
The internal mammary vessels are the standard recipient in autologous breast reconstruction. Rib-sparing techniques have evolved to routine use, limiting surgical field for vessel preparation a minimum. An inframammary approach skin-sparing mastectomy provides aesthetically pleasing results but might impede exposure even further. We developed simple yet elaborate technique expose of staff- and cost-efficient manner while using basic tools.
Breast cancer is the most common in women globally, often necessitating mastectomy and subsequent breast reconstruction. Silicone mammary implants (SMIs) play a pivotal role reconstruction, yet their interaction with host immune system microbiome remains poorly understood. This study investigates impact of SMI surface topography on antimicrobial responses, wound proteome dynamics, microbial colonization. Biological samples were col-lected from ten human patients undergoing reconstruction...
The most common long-term complication of silicone breast implants (SMI) remains capsular fibrosis. etiology this exaggerated implant encapsulation is multifactorial but primarily induced by the host response towards foreign material silicone. Identified risk factors include specific topographies. Of note, implant-associated anaplastic large cell lymphoma (BIA-ALCL) has only been observed in to textured surface implants. We hypothesize that reduction SMI roughness causes less and, hence,...
Breast cancer is the most common in women globally, often necessitating mastectomy and subsequent breast reconstruction. Silicone mammary implants (SMIs) play a pivotal role reconstruction, yet their interaction with host immune system microbiome remains poorly understood. This study investigates impact of SMI surface topography on antimicrobial responses, wound proteome dynamics, microbial colonization. Biological samples were collected from ten human patients undergoing reconstruction...
Dupuytren's disease is characterised by fibrotic nodule and cord formation in the palmar aponeurosis. The pathophysiology of still unknown, although cell stress subsequent activation immune mechanisms seems to be crucial.Surgically obtained tissue blood samples 100 Dupuytren patients were processed immunohistochemistry, flow cytometry, as well immunoscope analysis. Macroscopically normal aponeurotic served control.Locally, microvascular alterations massive infiltration mononuclear cells...
Acute skin rejection in vascularized composite allotransplantation (VCA) is the major obstacle for wider adoption clinical practice. This study utilized computational modeling to identify biomarkers diagnosis and targets treatment of rejection. Protein levels 14 inflammatory mediators muscle biopsies from syngeneic grafts [n = 10], allogeneic transplants without immunosuppression 10] allografts treated with tacrolimus were assessed by multiplexed analysis technology. Hierarchical Clustering...
In Brief The lower abdominal skin and fat have become a standard for breast reconstruction because the tissue can mimic to high degree. With today's increasing focus on safety routine of microsurgical interventions, more attention must be paid donor-site morbidity. superficial inferior epigastric artery (SIEA) free flap is least invasive procedure this operative technique does not require harvesting rectus muscle or fascia. A total 11 reconstructions were performed with had an average...
Human abdominal subcutaneous adipose tissue consists of two individual layers—the superficial (SAT) and deep (DAT)—separated by the Scarpa’s fascia. The present study focuses on analysis morphological immunological differences primary adipocytes, adipose-derived stem cells (ASC), tissue-infiltrating immune found in SAT DAT. Adipocytes stromal vascular fraction (SVF) were isolated from human DAT specimens phenotypically characterized vitro assays. Ex vivo infiltrating was performed flow...
Advances in microsurgical techniques and immunosuppressive medication have rendered transplantation of vascularized composite allografts possible, when autologous tissue is neither available nor sufficient for reconstruction. However, skin rejection side effects long-term immunosuppression still remain a major hurdle wide adoption this excellent reconstructive technique. Histopathologic changes during acute vascular allotransplantation often mimic inflammatory disorders are hard to...