A5014063157- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Retinal and Optic Conditions
- Clinical practice guidelines implementation
- Peripheral Artery Disease Management
- S100 Proteins and Annexins
- Intracerebral and Subarachnoid Hemorrhage Research
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
University of Helsinki
2016-2024
Helsinki University Hospital
2018-2024
King's College London
2024
University College London
2024
National and Kapodistrian University of Athens
2024
University of Gothenburg
2018
Sahlgrenska University Hospital
2018
Recanalization is considered a prerequisite for favorable outcome in basilar artery occlusion (BAO). Intravenous thrombolysis (IVT) has been successfully used eligible patients with BAO well beyond the 4.5-hour time window but largely underrepresented best medical management arms recent randomized controlled trials of recanalization therapy BAO. We aimed to analyze outcomes treated IVT only and compare endovascular thrombectomy (EVT).
Plasma glial fibrillary acidic protein (GFAP) and tau are promising markers for differentiating acute cerebral ischemia (ACI) hemorrhagic stroke (HS), but their prehospital dynamics usefulness unknown.We performed ultra-sensitivite single-molecule array (Simoa®) measurements of plasma GFAP total in a code patient cohort with cardinal symptoms [National Institutes Health Stroke Scale (NIHSS) ≥3]. Sequential sampling included 2 ultra-early samples, follow-up sample on the next morning.We 272...
The data on long-term outcome after basilar artery occlusion (BAO) are scarce. Little is known about BAO survivors´ over decades.We set out to investigate survival and causes of death in patients with up two decades follow-up. We also evaluated differences trends.Two hundred seven treated intravenous thrombolysis (IVT) at the Department Neurology, Helsinki University Hospital, between 1995 2016, were analyzed. Short-term was assessed by modified Rankin Scale (mRS) 3 months. Long-term...
Background: Around 30-60% of patients with basilar artery occlusion (BAO) present coma, which is often considered as a hallmark poor prognosis. Aim: To examine factors that will help predict outcomes in BAO comatose on admission. Methods: A total 312 angiography-proven were analyzed. Comas assessed Glasgow Coma Scale (GCS) ≤8 or impaired level consciousness ascertained the medical records. Outcomes evaluated modified Rankin (mRS) over phone call at 3 months. In our study, 53 excluded due to...
Objectives Blood-based biomarkers could enable early and cost-effective diagnostics for acute stroke patients in the prehospital setting to support initiation of treatments. To facilitate development ultra-acute biomarkers, we set out implement large-scale blood sampling determine feasibility diagnostic timesavings this approach. Materials Methods Emergency medical services (EMS) personnel Helsinki metropolitan area were trained collect samples from thrombolysis candidates using a cannula...
Background and purpose Patients suffering from basilar artery occlusion (BAO) treated with intravenous thrombolysis are, in some centers, started on adjunct anticoagulation hyperacute settings. We aimed to assess the outcome of such patients compare low‐molecular weight heparin (LMWH) unfractionated (UFH) this context. Methods examined 211 angiography‐proven BAO either UFH or LMWH. Main variables were rate symptomatic intracranial hemorrhage (sICH) according European Cooperative Acute Stroke...
Background Accurate identification of acute stroke by Emergency Medical Dispatchers (EMD) is essential for timely and purposeful deployment Services (EMS), a prerequisite operating mobile units. However, precision EMD recognition currently modest. Aims We sought to identify targets improving dispatcher identification. Methods Dispatch codes EMS patient records were cross-linked investigate factors associated with an incorrect dispatch code in prospective observational cohort 625 patients...
Basilar artery occlusion (BAO) leads to high rates of morbidity and mortality, despite successful recanalization. The discordance between flow restoration long-term functional status clouds clinical decision-making regarding further aggressive care. We sought develop validate a practical, prognostic tool for the prediction 3-month favorable outcome after acute reperfusion therapy BAO.This retrospective, multicenter, observational study was conducted at four high-volume stroke centers in USA...
To clarify diagnostic accuracy and consequences of misdiagnosis in the admission evaluation stroke-code patients a neurologic emergency department with less than 20-minute door-to-thrombolysis times.Accuracy diagnostics was studied an observational cohort 1,015 arriving by ambulance as candidates for recanalization therapy between May 2013 November 2015. Immediate performed stroke neurologist or neurology resident dedicated training, primarily utilizing CT-based imaging.The rate correct...
Introduction After severe ischemic stroke (IS), circulating levels of symmetric dimethylarginine (SDMA) increase. We investigated the early dynamics SDMA in to potentially aid with prehospital identification IS from hemorrhagic (HS). Methods performed targeted mass spectrometry (MS) measurements two sequential acute plasma samples (early and secondary) 50 patients LVO 49 HS patients. Secondary 227 84 moderate symptoms (NIHSS ≥ 7) subsequently underwent ELISA validation. Results The median...
Background and purpose: Blood-based biomarkers could enable early cost-effective diagnostics for acute stroke patients in the prehospital setting to support initiation of treatments. However, large sample sets required biomarker discovery validation are missing, feasibility large-scale blood sampling by emergency medical services (EMS) has not been determined. We set out establish extensive thrombolysis candidates catchment area our comprehensive center, with a 1.5 million population base....