A5033877874- Pituitary Gland Disorders and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Hepatitis C virus research
- Growth Hormone and Insulin-like Growth Factors
- Biosimilars and Bioanalytical Methods
- Multiple Sclerosis Research Studies
- Rheumatoid Arthritis Research and Therapies
- Metabolomics and Mass Spectrometry Studies
- Analytical Chemistry and Chromatography
- Lymphoma Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Liver Disease Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Chronic Lymphocytic Leukemia Research
- Sexual function and dysfunction studies
- Economic and Financial Impacts of Cancer
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Cellular transport and secretion
- Analytical Methods in Pharmaceuticals
- Polyomavirus and related diseases
- Multiple and Secondary Primary Cancers
- Pharmaceutical Economics and Policy
- Lysosomal Storage Disorders Research
- Antifungal resistance and susceptibility
Universidade Federal do Paraná
2015-2023
Instituto de Pesquisas Jardim Botânico do Rio de Janeiro
2018
An ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry method for the simultaneous quantification of chlorpropamide, glibenclamide, gliclazide, glimepiride, metformin, nateglinide, pioglitazone, rosiglitazone, and vildagliptin in human plasma was developed validated, using isoniazid sulfaquinoxaline as internal standards. Following protein precipitation acetonitrile with 1% formic acid, chromatographic separation performed on a cyano column gradient elution...
Coumarin (1,2-benzopyrone) is a natural compound whose metabolism in humans was established the 1970s. However, new metabolite recently identified human plasma, indicating that of coumarin has not been completely elucidated. To complement knowledge its metabolism, rapid and sensitive method using UPLC-QTOF-MS developed. A total 12 metabolites MetaboLynxTM software, including eight previously reported urine. The biotransformation included hydroxylation, glucuronidation, sulfation,...
<b><i>Objectives:</i></b> To conduct a cost-utility analysis comparing drug strategies involving octreotide, lanreotide, pasireotide, and pegvisomant for the treatment of patients with acromegaly who have failed surgery, from Brazilian public payer perspective. <b><i>Methods:</i></b> A probabilistic cohort Markov model was developed. One-year cycles were employed. The started at 45 years age followed lifelong. Costs, efficacy, quality life...