A5037445016- Face Recognition and Perception
- Visual perception and processing mechanisms
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Advanced MRI Techniques and Applications
- Face recognition and analysis
- Advanced Neuroimaging Techniques and Applications
- Evolutionary Psychology and Human Behavior
- Visual Attention and Saliency Detection
- Neural and Behavioral Psychology Studies
- Diverticular Disease and Complications
- Gaze Tracking and Assistive Technology
- Computational Physics and Python Applications
- Spatial Neglect and Hemispheric Dysfunction
- Fetal and Pediatric Neurological Disorders
- Cancer Genomics and Diagnostics
- Face and Expression Recognition
- Morphological variations and asymmetry
- Nicotinic Acetylcholine Receptors Study
- Multisensory perception and integration
- Time Series Analysis and Forecasting
- Advancements in Photolithography Techniques
- Speech and Audio Processing
- Urologic and reproductive health conditions
- Monoclonal and Polyclonal Antibodies Research
MRC Cognition and Brain Sciences Unit
2011-2022
University of Cambridge
2012-2021
Medical Research Council
2010-2015
RIKEN Center for Brain Science
2014
Salford Royal Hospital
1999
Humans show a remarkable ability to discriminate others' gaze direction, even though given direction can be conveyed by many physically dissimilar configurations of different eye positions and head views. For example, contact signaled rightward glance in left-turned or direct front-facing head. Such acute discrimination implies considerable perceptual invariance. Previous human research found that superior temporal sulcus (STS) responds preferentially shifts [1Nummenmaa L. Calder A.J. Neural...
Behavior is governed by rules that associate stimuli with responses and outcomes. Human monkey studies have shown rule-specific information widely represented in the frontoparietal cortex. However, it not known how establishing a rule under different contexts affects its neural representation. Here, we use event-related functional MRI (fMRI) multivoxel pattern classification methods to investigate human brain9s mechanisms of maintaining for multiple perceptual decision tasks. Rules were...
The perceptual representation of individual faces is often explained with reference to a norm-based face space. In such spaces, individuals are encoded as vectors where identity primarily conveyed by direction and distinctiveness eccentricity. Here we measured human fMRI responses psychophysical similarity judgments exemplars, which were generated realistic 3D animations using computer-graphics model. We developed evaluated multiple neurobiologically plausible computational models, each...
Brain imaging researchers regularly work with large, heterogeneous, high-dimensional datasets.Historically, have dealt this complexity idiosyncratically, every lab or individual implementing their own preprocessing and analysis procedures.The resulting lack of field-wide standards has severely limited reproducibility data sharing reuse.
Humans and other primates are adept at using the direction of another's gaze or head turn to infer where that individual is attending.Research in macaque neurophysiology suggests anterior superior temporal sulcus (STS) contains a directionsensitive code for such social attention cues.By contrast, most human functional Magnetic resonance imaging (fMRI) studies report posterior STS responsive cues.It unclear whether this discrepancy caused by species difference experimental design...
Abstract We evaluated the effectiveness of prospective motion correction (PMC) on a simple visual task when no deliberate subject was present. The PMC system utilizes an in‐bore optical camera to track external marker attached participant via custom‐molded mouthpiece. study conducted at two resolutions (1.5 mm vs 3 mm) and under three conditions (PMC On Mouthpiece Off Off). Multiple data analysis methods were conducted, including univariate multivariate approaches, we demonstrated that...
Human visual cortex shows retinotopic organization during both perception and attention, but whether this remains true for short-term memory (VSTM) is uncertain. In 2 functional magnetic resonance imaging experiments, we separated activation perception, VSTM maintenance. The experiments differed in spatial encoding of the stimuli prospective attention to locations remembered items was encouraged or discouraged. Using multivoxel pattern analysis extract a measure coding early cortex, saw...
Abstract The thickness and surface area of cortex are genetically distinct aspects brain structure, may be affected differently by age. However, their potential to differentially predict age cognitive abilities has been largely overlooked, likely because they typically aggregated into the commonly used measure volume . In a large sample healthy adults (N=647, aged 18-88), we investigated brain-age brain-cognition relationships thickness, area, volume, plus five additional morphological shape...
Ultra-high field functional magnetic resonance imaging (fMRI) has allowed us to acquire images with submillimetre voxels. However, in order interpret the data clearly, we need accurately correct head motion and resultant distortions. Here, present a novel application of Boundary Based Registration (BBR) realign Magnetic Resonance Imaging evaluate its effectiveness on set 7T data, as well millimetre 3T for comparison. BBR utilizes boundary information from high contrast structural drive...
The arrival of submillimeter ultra high-field fMRI makes it possible to compare activation profiles across cortical layers. However, the blood oxygenation level dependent (BOLD) signal measured by gradient echo (GE) is biased toward superficial layers cortex, which a serious confound for laminar analysis. Several univariate and multivariate analysis methods have been proposed correct this bias. We these using computational simulations 7T data from regions interest (ROI) during visual...
Parallel transmission (pTx) is an approach to improve image uniformity for ultra-high field imaging. In this study, we modified echo planar imaging (EPI) sequence design subject-specific pTx pulses online. We compared its performance against EPI with conventional circularly polarised (CP) pulses. the pTx-EPI and CP-EPI sequences in a short acquisition protocol two different functional paradigms six healthy volunteers (2 female, aged 23–36 years, mean age 29.2 years). chose that are typically...
Visual processing involves feedforward and recurrent signals. Understanding which computations are performed in the sweep require has been challenging. We used fMRI MEG to characterize spatial temporal components of human visual object representations. In experiment, we brief stimulus presentation (16.7ms) a backward masking paradigm with short long interstimulus intervals (ISI) distinguish contributions processing. short-ISI trials, mask was presented 37ms after onset (ISI=20ms),...
1 Abstract The arrival of submillimetre ultra high-field fMRI makes it possible to compare activation profiles across cortical layers. However, the Blood Oxygenation Level Dependent (BOLD) signal measured by Gradient-Echo is biased towards superficial layers cortex, which a serious confound for laminar analysis. Several univariate and multivariate analysis methods have been proposed correct this bias. We these using computational simulations example human 7T data from Regions-of-Interest...
Abstract The perceptual representation of individual faces is often explained with reference to a norm-based face space. In such spaces, individuals are encoded as vectors where identity primarily conveyed by direction and distinctiveness eccentricity. Here we measured human fMRI responses psychophysical similarity judgments exemplars, which were generated realistic 3D animations using computer-graphics model. We developed evaluated multiple neurobiologically plausible computational models,...
Humans and monkeys alike are sensitive to where other individuals looking, an ability that is fundamental social cognition. In monkeys, neurons in anterior superior temporal sulcus (STS) selective for the direction of others' head turns eye gaze, but it not currently known whether human STS codes a similar manner. We used multivariate pattern analysis (MVPA) functional MRI data investigate motion. Using dynamic video stimuli, we found voxel response patterns posterior discriminate left right...
Abstract Ultra-high field functional magnetic resonance imaging (fMRI) has allowed us to acquire images with submillimetre voxels. However, in order interpret the data clearly, we need accurately correct head motion and resultant distortions. Here, present a novel application of Boundary Based Registration (BBR) realign Magnetic Resonance Imaging evaluate its effectiveness on set 7T data, as well millimetre 3T for comparison. BBR utilizes boundary information from high contrast structural...
Human observers easily prioritize processing of task-relevant stimuli in cluttered visual scenes. This study used fMRI to characterize how effectively regions across human cortex filter a target's spatial location or content from task-irrelevant distractors. Nine subjects performed task that involved following cues attend (faces houses, 9 degrees angle diameter) one two parallel stimulus streams (5.1 above below fixation) 16.2s blocks. We cross-classifiers obtain separate readouts...