A5016820068- Toxoplasma gondii Research Studies
- Herpesvirus Infections and Treatments
- Asthma and respiratory diseases
- Antimicrobial Peptides and Activities
- Peptidase Inhibition and Analysis
- Parasitic Infections and Diagnostics
- Travel-related health issues
- Neonatal Respiratory Health Research
- Food Allergy and Anaphylaxis Research
- Protease and Inhibitor Mechanisms
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
Consejo Nacional de Investigaciones Científicas y Técnicas
2017-2023
National University of General San Martín
2015-2023
Serine-proteases are important players in the pathogenesis of asthma, promoting inflammation and tissue remodeling. It’s also known that many serine protease inhibitors display immunomodulatory properties. TgPI-1 is a Toxoplasma gondii protein exhibits broad spectrum inhibitory activity against proteases. In view increased prevalence atopic disorders need to develop new treatment strategies we sought investigate potential for treating respiratory allergies. For this purpose, developed...
We have previously showed rTgPI-1 tolerogenic adjuvant properties in asthma treatment, turning it a promising candidate for allergen-specific immunotherapy. This therapy is an alternative treatment to control that still presents several concerns related its formulation. contains independent inhibitory domains able inhibit trypsin and neutrophil elastase, both involved pathology.In view of the need design rational therapies, herein we investigated contribution different therapeutic...