A5046187830- Genomics and Chromatin Dynamics
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Hippo pathway signaling and YAP/TAZ
- Chromosomal and Genetic Variations
- Genetics, Bioinformatics, and Biomedical Research
- Plant Molecular Biology Research
- Plant Reproductive Biology
- RNA Interference and Gene Delivery
- RNA and protein synthesis mechanisms
- Animal Genetics and Reproduction
- Wnt/β-catenin signaling in development and cancer
- Insect Resistance and Genetics
- Developmental Biology and Gene Regulation
University of North Carolina at Chapel Hill
2015-2022
UNC Lineberger Comprehensive Cancer Center
2022
Florida State University
2010-2016
Abstract Mono-methylation of histone H4 lysine 20 (H4K20me1) is catalyzed by Set8/KMT5A and regulates numerous aspects genome organization function. Loss-of-function mutations in Drosophila melanogaster Set8 or mammalian KMT5A prevent H4K20me1 disrupt development. also has non-histone substrates, making it difficult to determine which developmental functions are attributable other substrates non-catalytic roles. Here, we show that human can functionally substitute for during development the...
During Drosophila oogenesis, the endopolyploid nuclei of germ-line nurse cells undergo a dramatic shift in morphology as oogenesis progresses; easily-visible chromosomes are initially polytenic during early stages before they transiently condense into distinct '5-blob' configuration, with subsequent dispersal diffuse state. Mutations many genes, diverse cellular functions, can affect ability to fully decondense their chromatin, resulting '5-blob arrest' phenotype that is maintained...
AbstractDuring Drosophila oogenesis, nurse cells undergo changes in chromosomal morphology, first from the polytenic form to a transient condensed phase known as five-blob configuration, then into diffuse polytenic-polyploid state for remainder of oogenesis. The mechanism by which nurse-cell chromosome dispersal is regulated remains elusive. Mutations several genes, including heterogeneous ribonucleoprotein genes squid (sqd) and hrb27C, alternative splicing factor gene poly U binding 68kDa...
Abstract Mono-methylation of histone H4 lysine 20 (H4K20me1) is catalyzed by Set8/KMT5A and regulates numerous aspects genome organization function. Loss-of-function mutations in Drosophila melanogaster Set8 or mammalian KMT5A prevent H4K20me1 disrupt development. also has non-histone substrates, making it difficult to determine which developmental functions are attributable other substrates non-catalytic roles. Here, we show that human can functionally substitute for during development the...